Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM454837
Substrate
n/a
Meas. Tech.
FLIPR Assay in PAR4-Expressing HEK293 Cells
IC50
2.40±n/a nM
Citation
 Fu, Q; Zhang, X; Priestley, ES; Halpern, OS; Reznik, SK; Richter, JM Bicyclic heteroaryl substituted compounds US Patent  US10730868 Publication Date 8/4/2020 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM454837
Synonyms:
US10730868, Ex. No. 104 | rac-cis-5-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)benzo[d]thiazol-6-yl)oxy)-2,2-dimethylcyclopentyl (2-methylpyrimidin-5-yl)carbamate
Type:
Small organic molecule
Emp. Form.:
C30H29FN6O4S
Mol. Mass.:
588.652
SMILES:
COc1cnc2c(cc(C)cc2n1)-c1nc2cc(F)c(O[C@@H]3CCC(C)(C)[C@@H]3OC(=O)Nc3cnc(C)nc3)cc2s1 |r|
Structure:
Search PDB for entries with ligand similarity: