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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM455772
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Vechorkin, O; Atasoylu, O; Ye, HF; Liu, K; Zhang, K; Yao, W Cyanoindazole compounds and uses thereof US Patent  US10722495 Publication Date 7/28/2020 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM455772
Synonyms:
US10722495, Example 19
Type:
Small organic molecule
Emp. Form.:
C27H24FN5
Mol. Mass.:
437.5114
SMILES:
CNCc1cc(C)c(c(F)c1)-c1cc2c(n[nH]c2cc1C#N)-c1ccc(cc1)C(C)(C)C#N |(8.37,-2.47,;7.03,-1.7,;5.7,-2.47,;4.37,-1.7,;4.37,-.16,;3.03,.61,;3.03,2.15,;1.7,-.16,;1.7,-1.7,;.37,-2.47,;3.03,-2.47,;.37,.61,;-.97,-.16,;-2.3,.61,;-3.77,.14,;-4.67,1.38,;-3.77,2.63,;-2.3,2.15,;-.97,2.92,;.37,2.15,;1.7,2.92,;3.03,3.69,;-4.24,-1.33,;-3.21,-2.47,;-3.69,-3.94,;-5.19,-4.26,;-6.22,-3.11,;-5.75,-1.65,;-5.67,-5.72,;-7.13,-5.24,;-4.21,-6.2,;-6.15,-7.18,;-6.62,-8.65,)|
Structure:
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