Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM457052
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Ki
55.0±n/a nM
Citation
 Ratcliffe, P; Konetzki, I; Sitnikov, N; Koch, T; Jostock, R 1,3-diaza-spiro-[3.4]-octane derivatives US Patent  US10738015 Publication Date 8/11/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM457052
Synonyms:
Cis-5-(cyclopropylmethyl)-2- (dimethylamino)-2-(3- fluorophenyl)-7-(5- (trifluoromethoxy)pyridin-2- yl)-5,7-diazaspiro[3.4]octan-6- one | US10738015, Example SC-18
Type:
Small organic molecule
Emp. Form.:
C24H26F4N4O2
Mol. Mass.:
478.4825
SMILES:
CN(C)[C@]1(C[C@@]2(C1)CN(C(=O)N2CC1CC1)c1ccc(OC(F)(F)F)cn1)c1cccc(F)c1 |r,wU:5.5,3.2,(3.93,2.3,;4.33,.82,;5.82,.42,;3.24,-.27,;2.16,-1.36,;1.07,-.27,;2.16,.82,;.3,1.06,;-1.21,.74,;-1.37,-.79,;-2.7,-1.56,;.04,-1.42,;.36,-2.92,;-.79,-3.95,;-2.29,-4.27,;-1.26,-5.42,;-2.35,1.77,;-2.03,3.28,;-3.18,4.31,;-4.64,3.83,;-5.79,4.86,;-7.25,4.39,;-7.57,2.88,;-8.4,5.42,;-6.16,3.3,;-4.96,2.33,;-3.82,1.3,;4.33,-1.36,;3.93,-2.85,;5.02,-3.94,;6.51,-3.54,;6.91,-2.05,;8.4,-1.65,;5.82,-.96,)|
Structure:
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