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Target
Period circadian protein homolog 2
Ligand
BDBM356724
Substrate
n/a
Meas. Tech.
High-Throughput Assay
EC50
89.0±n/a nM
Citation
 Bersot, R; Humphries, P Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators US Patent  US10759777 Publication Date 9/1/2020 
Target
Name:
Period circadian protein homolog 2
Synonyms:
Circadian clock protein PERIOD 2 | KIAA0347 | PER2 | PER2_HUMAN | Period circadian protein homolog 2 | hPER2
Type:
PROTEIN
Mol. Mass.:
136576.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116705
Residue:
1255
Sequence:
MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRDQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKSVTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKAESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPFKKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRNTSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSSCPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPLAPVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPCACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGADCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSGSLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLMADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLPAAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT
  
Inhibitor
Name:
BDBM356724
Synonyms:
(1R,4S)-2-((R)-3- (9H-carbazol-9-yl)- 2-hydroxypropyl)- 2-azabi- cyclo[2.2.1]heptan- 3-one | US10214507, Compound 107 | US10759777, Compound 107
Type:
Small organic molecule
Emp. Form.:
C21H22N2O2
Mol. Mass.:
334.4116
SMILES:
O[C@@H](CN1[C@@H]2CC[C@@H](C2)C1=O)Cn1c2ccccc2c2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: