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Target
Nociceptin receptor
Ligand
BDBM469749
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
14.0±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469749
Synonyms:
US10807988, Example SC_3386 | cis-8-Dimethylamino-8-(3-fluoro-5-methyl-phenyl)-3-[4-methyl-6- (trifluoromethyl)-pyridin-3-yl]-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C24H28F4N4O
Mol. Mass.:
464.4989
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2cnc(cc2C)C(F)(F)F)CC1)c1cc(C)cc(F)c1 |r,wU:6.11,3.2,(-7.53,12.66,;-9.07,12.66,;-9.84,13.99,;-9.84,11.33,;-10.61,9.99,;-12.15,9.99,;-12.92,11.33,;-13.82,12.57,;-15.29,12.1,;-15.29,10.56,;-16.62,9.79,;-13.82,10.08,;-16.38,13.19,;-17.86,12.79,;-18.95,13.88,;-18.55,15.36,;-17.07,15.76,;-15.98,14.67,;-14.49,15.07,;-19.64,16.45,;-20.73,15.36,;-18.55,17.54,;-20.73,17.54,;-12.15,12.66,;-10.61,12.66,;-9.07,9.99,;-9.84,8.66,;-9.07,7.33,;-9.84,5.99,;-7.53,7.33,;-6.76,8.66,;-5.22,8.66,;-7.53,9.99,)|
Structure:
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