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Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM476277
Substrate
n/a
Meas. Tech.
Biological Activity of Selected Compounds of the Invention
EC50
<100.0±n/a nM
Citation
 Bannister, TD; Wang, H; Wang, C; Cleveland, JL Pteridine dione monocarboxylate transporter inhibitors US Patent  US10874675 Publication Date 12/29/2020 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM476277
Synonyms:
US10874675, Example 16
Type:
Small organic molecule
Emp. Form.:
C24H29F3N4O4
Mol. Mass.:
494.5067
SMILES:
CC(C)Cn1c2nc(COc3cccc(c3)C(F)(F)F)c(CCCCCO)nc2c(=O)n(C)c1=O
Structure:
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