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Target
Ubiquitin carboxyl-terminal hydrolase 25
Ligand
BDBM478046
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
6000±n/a nM
Citation
 Guerin, DJ; Bair, KW; Caravella, JA; Ioannidis, Jr., S; Lancia, Jr., DR; Li, H; Mischke, S; Ng, PY; Richard, D; Schiller, SE; Shelekhin, T; Wang, Z Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors US Patent  US10889592 Publication Date 1/12/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 25
Synonyms:
3.4.19.12 | Deubiquitinating enzyme 25 | UBP25_HUMAN | USP on chromosome 21 | USP21 | USP25 | Ubiquitin carboxyl-terminal hydrolase 25 | Ubiquitin thioesterase 25 | Ubiquitin-specific-processing protease 25
Type:
PROTEIN
Mol. Mass.:
122185.70
Organism:
Homo sapiens
Description:
ChEMBL_118220
Residue:
1055
Sequence:
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
  
Inhibitor
Name:
BDBM478046
Synonyms:
US10889592, Compound I-19 | US11325917, Compound I-19
Type:
Small organic molecule
Emp. Form.:
C24H27N7OS
Mol. Mass.:
461.582
SMILES:
C[C@@H](CNC(=O)c1sc2nc(C)cnc2c1N)c1ccc(N2CC3CCC(C2)N3)c(c1)C#N |r,TLB:20:21:28:24.25|
Structure:
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