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Target
Alpha-synuclein
Ligand
BDBM481758
Substrate
n/a
Meas. Tech.
In-Vitro Fluorescence Polarization Assay
IC50
900±n/a nM
Citation
 Hall, A Bis-heteroaryl derivatives as modulators of protein aggregation US Patent  US10913735 Publication Date 2/9/2021 
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM481758
Synonyms:
N-[1-(1H-indol-3- ylmethyl)pentyl]-2-[4-(2- methylpyrazol-3- yl)piperazin-1-yl]thiazole- 5-carboxamide | US10913735, Example 14
Type:
Small organic molecule
Emp. Form.:
C26H33N7OS
Mol. Mass.:
491.652
SMILES:
CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1ccnn1C
Structure:
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