Reaction Details
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Endothelin-1
Ligand
BDBM172885
Substrate
n/a
Meas. Tech.
ET-1 Assay
EC50
<50000±n/a nM
Citation
PubChem, PC; Buckman, BO; Nicholas, JB; Ramphal, JY; Emayan, K; Seiwert, SD Anti-fibrotic pyridinones US Patent US9675593 Publication Date 6/13/2017 More Info.:
Target
Name:
Endothelin-1
Synonyms:
EDN1 | EDN1_HUMAN | PPET1 | Preproendothelin-1
Type:
Protein
Mol. Mass.:
24444.51
Organism:
Homo sapiens (Human)
Description:
P05305
Residue:
212
Sequence:
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW
Inhibitor
Name:
BDBM172885
Synonyms:
US9675593, 694
Type:
Small organic molecule
Emp. Form.:
C20H17F3N4O2
Mol. Mass.:
402.3698
SMILES:
CCn1ccc2c1c(cn(-c1ccc(OC(F)(F)F)cc1)c2=O)-c1cnn(C)c1
Structure:
