Reaction Details Report a problem with these data
Target
AP-4 complex subunit sigma-1
Ligand
BDBM484124
Substrate
n/a
Meas. Tech.
Human Sigma-1 Receptor Radioligand Assay
Ki
<100±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C Oxadiazaspiro compounds for the treatment of drug abuse and addiction US Patent  US10927128 Publication Date 2/23/2021 
Target
Name:
AP-4 complex subunit sigma-1
Synonyms:
AP-4 complex subunit sigma-1 | AP4S1 | AP4S1_HUMAN | Sigma-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17000.04
Organism:
Homo sapiens (Human)
Description:
Sigma-1 0 HUMAN::Q9Y587
Residue:
144
Sequence:
MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSES
  
Inhibitor
Name:
BDBM484124
Synonyms:
9-isopentyl-4-isopropyl-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.5]undecan-3- one | US10927128, Example 45 | US11649248, Example 45
Type:
Small organic molecule
Emp. Form.:
C18H34N2O2
Mol. Mass.:
310.4748
SMILES:
CC(C)CCN1CCC2(CC1)CN(C(C)C)C(=O)C(C)(C)O2
Structure:
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