Reaction Details Report a problem with these data
Target
AP-4 complex subunit sigma-1
Ligand
BDBM484151
Substrate
n/a
Meas. Tech.
Human Sigma-1 Receptor Radioligand Assay
Ki
<100±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C Oxadiazaspiro compounds for the treatment of drug abuse and addiction US Patent  US10927128 Publication Date 2/23/2021 
Target
Name:
AP-4 complex subunit sigma-1
Synonyms:
AP-4 complex subunit sigma-1 | AP4S1 | AP4S1_HUMAN | Sigma-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17000.04
Organism:
Homo sapiens (Human)
Description:
Sigma-1 0 HUMAN::Q9Y587
Residue:
144
Sequence:
MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSES
  
Inhibitor
Name:
BDBM484151
Synonyms:
(S)-9-(4-chlorobenzyl)-4- ethyl-2-methyl-1-oxa-4,9- diazaspiro[5.5]undecan-3- one | US10927128, Example 72 | US11649248, Example 72
Type:
Small organic molecule
Emp. Form.:
C18H25ClN2O2
Mol. Mass.:
336.856
SMILES:
CCN1CC2(CCN(Cc3ccc(Cl)cc3)CC2)O[C@@H](C)C1=O |r|
Structure:
Search PDB for entries with ligand similarity: