Reaction Details Report a problem with these data
Target
AP-4 complex subunit sigma-1
Ligand
BDBM484166
Substrate
n/a
Meas. Tech.
Human Sigma-1 Receptor Radioligand Assay
Ki
<100±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C Oxadiazaspiro compounds for the treatment of drug abuse and addiction US Patent  US10927128 Publication Date 2/23/2021 
Target
Name:
AP-4 complex subunit sigma-1
Synonyms:
AP-4 complex subunit sigma-1 | AP4S1 | AP4S1_HUMAN | Sigma-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17000.04
Organism:
Homo sapiens (Human)
Description:
Sigma-1 0 HUMAN::Q9Y587
Residue:
144
Sequence:
MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSES
  
Inhibitor
Name:
BDBM484166
Synonyms:
(S)-4-((4-cyclopropyl-2- methyl-3-oxo-1-oxa-4,9- diazaspiro[5.5]undecan-9- yl)methyl)benzonitrile | US10927128, Example 87 | US11649248, Example 87
Type:
Small organic molecule
Emp. Form.:
C20H25N3O2
Mol. Mass.:
339.4314
SMILES:
C[C@@H]1OC2(CCN(Cc3ccc(cc3)C#N)CC2)CN(C2CC2)C1=O |r|
Structure:
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