Reaction Details Report a problem with these data
Target
GTPase KRas [G12D]
Ligand
BDBM485668
Substrate
n/a
Meas. Tech.
Binding Domain Inhibition Assay
IC50
20500±n/a nM
Citation
 Hadari, YR; Carta, L; Schmertzler, M; Williams, TM; Reynolds, CH; Hutcheson, R Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease US Patent  US10940139 Publication Date 3/9/2021 
Target
Name:
GTPase KRas [G12D]
Synonyms:
GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21713.12
Organism:
Homo sapiens (Human)
Description:
P01116[G12D]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM485668
Synonyms:
US10940139, Example 02799 | US11000515, Compound TABLE 7.350 | US11213515, TABLE 7.350 | US11541041, Compound Table 7.329
Type:
Small organic molecule
Emp. Form.:
C21H15N5O2S
Mol. Mass.:
401.441
SMILES:
O=C(COCc1ccc(cc1)C#N)Nc1nc(nc2sccc12)-c1ccccn1
Structure:
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