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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM487933
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
10.00±n/a nM
Citation
 Lu, T; Allison, BD; Barbay, JK; Connolly, PJ; Cummings, MD; Diels, G; Edwards, JP; Kreutter, KD; Philippar, U; Shen, F; Thuring, JW; Wu, T; Berthelot, DJ Pyrazole derivatives as MALT1 inhibitors US Patent  US10954214 Publication Date 3/23/2021 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM487933
Synonyms:
US10954214, Compound 355 | methyl 3-chloro-5-(1-(1-oxo-1,2- dihydroisoquinolin-5-yl)-5- (trifluoromethyl)-1H-pyrazole-4- carboxamido)picolinate
Type:
Small organic molecule
Emp. Form.:
C21H13ClF3N5O4
Mol. Mass.:
491.807
SMILES:
COC(=O)c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3c2cc[nH]c3=O)cc1Cl
Structure:
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