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Target
Stimulator of interferon genes protein
Ligand
BDBM490790
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
0.300±n/a nM
Citation
 Wythes, MJ; McAlpine, IJ; Patman, R; Rui, EY; Maderna, A; Jalaie, M; Gajiwala, KS Cyclopentane-based modulators of STING (stimulator of interferon genes) US Patent  US10968242 Publication Date 4/6/2021 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM490790
Synonyms:
US10968242, Example 17 Peak 2
Type:
Small organic molecule
Emp. Form.:
C21H24FN9O8P2S3
Mol. Mass.:
707.612
SMILES:
Cn1cnc2n(cnc2c1=O)[C@@H]1C[C@@H]2OP(S)(=S)O[C@H]3[C@@H](F)[C@@H](O[C@@H]3COP(S)(=O)O[C@@H]1[C@H]2O)n1cnc2c(N)ncnc12 |r|
Structure:
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