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Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM493019
Substrate
n/a
Meas. Tech.
JAK1 and JAK3 Enzyme Activity Assays
IC50
55±n/a nM
Citation
 Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same US Patent  US10981906 Publication Date 4/20/2021 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM493019
Synonyms:
US10981906, Example 118 | methyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H21N5O3
Mol. Mass.:
355.391
SMILES:
COC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)CC#N |r|
Structure:
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