Reaction Details Report a problem with these data
Target
Ribose-phosphate pyrophosphokinase 1
Ligand
BDBM493448
Substrate
n/a
Meas. Tech.
PRS Enzyme Activity Inhibition Experiment
IC50
300±n/a nM
Citation
 Lee, B; Cho, M; Lee, H; Jung, M; Oh, Y Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same US Patent  US10981917 Publication Date 4/20/2021 
Target
Name:
Ribose-phosphate pyrophosphokinase 1
Synonyms:
PRPS1 | PRPS1_HUMAN | Ribose-phosphate pyrophosphokinase I
Type:
PROTEIN
Mol. Mass.:
34836.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156521
Residue:
318
Sequence:
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
  
Inhibitor
Name:
BDBM493448
Synonyms:
US10981917, Example 149
Type:
Small organic molecule
Emp. Form.:
C18H23BrN2O3
Mol. Mass.:
395.291
SMILES:
COC(=O)c1cn(CCC[C@H]2NCCC[C@@H]2O)c2c(Br)cccc12 |r|
Structure:
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