Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM497383
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Disubstituted compounds for treatment of medical disorders US Patent  US11001600 Publication Date 5/11/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM497383
Synonyms:
US11001600, Cmp No. 45 | tert-butyl((5-(3- acetyl-1-(2- ((2S,4R)-2-((6- bromopyridin-2- yl)carbamoyl)-4- fluoropyrrolidin-1- yl)-2-oxoethyl)- 1H-indazol-5- yl)pyrimidin-2- yl)(methyl)(oxo)- 16-sulfaneylidene)- 14- azanecarboxylate
Type:
Small organic molecule
Emp. Form.:
C31H32BrFN8O6S
Mol. Mass.:
743.603
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)-c1cnc(nc1)S(C)(=O)=NC(=O)OC(C)(C)C |r|
Structure:
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