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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM501661
Substrate
n/a
Meas. Tech.
Inhibitory Enzyme Activity (In Vitro Assay)
IC50
55±n/a nM
Citation
 Thunuguntla, SS; Hosahalli, S; Panigrahi, SK; Schwarz, M; Arit, M 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors US Patent  US11028054 Publication Date 6/8/2021 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM501661
Synonyms:
US11028054, Example 59
Type:
Small organic molecule
Emp. Form.:
C25H21F4N3O2
Mol. Mass.:
471.4468
SMILES:
CC(C)NCc1cccc(c1)-c1c(F)c(F)c(-c2cc(C(O)=O)c3nc(C)[nH]c3c2)c(F)c1F
Structure:
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