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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7962
Substrate
BDBM7883
Meas. Tech.
QC Inhibition Testing
Ki
2300±n/a nM
Citation
 Schilling, S; Niestroj, AJ; Rahfeld, JU; Hoffmann, T; Wermann, M; Zunkel, K; Wasternack, C; Demuth, HU Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. J Biol Chem 278:49773-9 (2003) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM7962
Synonyms:
4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochloride | 4-(2-imidazol-1-yl-ethoxy)-benzoic acid | 4-[2-(1H-imidazol-1-yl)ethoxy]benzoic acid | CHEMBL267473 | CHEMBL537708 | Imidazole N-1 deriv. 13 | dazoxiben
Type:
Small organic molecule
Emp. Form.:
C12H12N2O3
Mol. Mass.:
232.2353
SMILES:
OC(=O)c1ccc(OCCn2ccnc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM7883
Synonyms:
(2S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanediamide | Gln-AMC | L-glutaminyl-4-methylcoumarinylamide
Type:
Small organic molecule
Emp. Form.:
C15H17N3O4
Mol. Mass.:
303.3132
SMILES:
Cc1cc(=O)oc2cc(NC(=O)[C@@H](N)CCC(N)=O)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: