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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7882
Substrate
BDBM7883
Meas. Tech.
QC Inhibition Testing
pH
8±n/a
Temperature
303.15±n/a K
Ki
160000±10000 nM
Km
48000±3000 nM
kcat
6±0.2 1/sec
Citation
 Schilling, S; Cynis, H; von Bohlen, A; Hoffmann, T; Wermann, M; Heiser, U; Buchholz, M; Zunkel, K; Demuth, HU Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase. Biochemistry 44:13415-24 (2005) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl-tRNA cyclotransferase | QPCT_MOUSE | Qpct | mQC
Type:
Enzyme
Mol. Mass.:
41122.35
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
362
Sequence:
MAGSEDKRVVGTLHLLLLQATVLSLTAGNLSLVSAAWTQEKNHHQPAHLNSSSLQQVAEGTSISEMWQNDLRPLLIERYPGSPGSYSARQHIMQRIQRLQAEWVVEVDTFLSRTPYGYRSFSNIISTLNPEAKRHLVLACHYDSKYFPRWDSRVFVGATDSAVPCAMMLELARALDKKLHSLKDVSGSKPDLSLRLIFFDGEEAFHHWSPQDSLYGSRHLAQKMASSPHPPGSRGTNQLDGMDLLVLLDLIGAANPTFPNFFPKTTRWFNRLQAIEKELYELGLLKDHSLERKYFQNFGYGNIIQDDHIPFLRKGVPVLHLIASPFPEVWHTMDDNEENLHASTIDNLNKIIQVFVLEYLHL
  
Inhibitor
Name:
BDBM7882
Synonyms:
1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138393, Imidazole | US9144538, Imidazole | imidazole
Type:
Small organic molecule
Emp. Form.:
C3H4N2
Mol. Mass.:
68.0773
SMILES:
c1c[nH]cn1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM7883
Synonyms:
(2S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanediamide | Gln-AMC | L-glutaminyl-4-methylcoumarinylamide
Type:
Small organic molecule
Emp. Form.:
C15H17N3O4
Mol. Mass.:
303.3132
SMILES:
Cc1cc(=O)oc2cc(NC(=O)[C@@H](N)CCC(N)=O)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: