Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM506731
Substrate
n/a
Meas. Tech.
IDO1 Cell-Based Assay
IC50
0.930±n/a nM
Citation
 Lewis, RT; Hamilton, M; Jones, P; Petrocchi, A; Reyna, N; McAfoos, T; Cross, JB; Soth, MJ Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase US Patent  US11046649 Publication Date 6/29/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM506731
Synonyms:
2-cyclopropyl-2- ((1R,3s,5S,6r)-3-((6- fluoroquinolin-4-yl)- oxy)bicyclo[3.1.0]hexan-6- yl)-N-(5-(trifluoromethyl)- 1H-pyrazol-3-yl)acetamide | US11046649, Ex. 109
Type:
Small organic molecule
Emp. Form.:
C24H22F4N4O2
Mol. Mass.:
474.4507
SMILES:
Fc1ccc2nccc(O[C@H]3C[C@H]4[C@@H](C3)[C@@H]4C(C3CC3)C(=O)Nc3cc([nH]n3)C(F)(F)F)c2c1 |r|
Structure:
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