| Assay Method Information | |
| | JHICC_CHT_Inh_3H uptake_CRC |
| Description: | Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening Center PI: Min Li, Ph.D. Assay Provider: Alicia Ruggiero, Ph.D., Vanderbilt University Medical Center Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1R03DA028852-01 Grant Proposal PI: Alicia Ruggiero, Ph.D., Vanderbilt University Medical Center Assay Implementation: Meng Wu Ph.D., Xiaofang Huang, M.S., Zhihong Lin, Ph. D., Kaiping Xu, M.S., Shunyou Long, M.S., and Owen McManus, Ph.D. Description: In the brain, the chemical acetylcholine (ACh) exerts powerful modulatory control over arousal, motor and cognitive circuits, and has been found to be deficient in Alzheimer's Disease (AD). The current drugs available to positively impact cognitive deficits in Alzheimer's Disease (AD) and other dementias are the cholinesterase inhibitors. These prevent the breakdown of the neurotransmitter |
| Affinity data for this assay | |
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