| Assay Method Information | |
| | Dissociation Constants (KD) Measurements |
| Description: | The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts induced on 2D 1H-15N HSQC upon the titration with the test compound was analyzed. The fit of the experimental data as a function of ligand concentration provided dissociation constant. |
| Affinity data for this assay | |
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