BindingDB PrimarySearch

Found 349 for UniProtKB: O43924

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50249989(CHEMBL1387422)

Ki: 8nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583530(CHEMBL5092661)

Ki: 8.60nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583533(CHEMBL5084153)

Ki: 9.30nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583534(CHEMBL5089219)

Ki: 14nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583525(CHEMBL5094121)

Ki: 26nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583524(CHEMBL5077941)

Ki: 29nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583527(CHEMBL5086138)

Ki: 39nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583532(CHEMBL5079726)

Ki: 41nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583531(CHEMBL5083136)

Ki: 44nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583529(CHEMBL5087129)

Ki: 45nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583526(CHEMBL5072868)

Ki: 49nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

Ki: 50nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)

Ki: 125nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583523(CHEMBL5084808)

Ki: 132nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583522(CHEMBL5082602)

Ki: 147nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM14363(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)

Ki: 400nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50583528(CHEMBL5092958)

Ki: >1.00E+3nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581180(CHEMBL5081214)

IC50: 0.100nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581182(CHEMBL5080391)

IC50: 0.126nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581183(CHEMBL5087564)

IC50: 0.158nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581184(CHEMBL5094110)

IC50: 0.251nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581185(CHEMBL5076558)

IC50: 0.316nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581181(CHEMBL5086895)

IC50: 0.316nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581179(CHEMBL5078680)

IC50: 1nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50581186(CHEMBL5088742)

IC50: 1nMAssay Description:Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP AssayMore data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM50492928(CHEMBL2414311)

IC50: 2.20nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM50399897(CHEMBL2180942)

IC50: 7.40nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

IC50: 9.5nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM50126469((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-propyl-...)

IC50: >10nMAssay Description:Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retinaMore data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)

IC50: 11nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair

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3D Structure (crystal)

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50019865(CHEMBL3286929)

IC50: 21nMAssay Description:Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce...More data for this Ligand-Target Pair

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3D Structure (crystal)

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529743(CHEMBL4440294)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529743(CHEMBL4440294)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50019865(CHEMBL3286929)

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3D Structure (crystal)

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529737(CHEMBL4459864)

IC50: 24nMAssay Description:Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce...More data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529737(CHEMBL4459864)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529736(CHEMBL4555739)

IC50: 25nMAssay Description:Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce...More data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529732(CHEMBL4527667)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529736(CHEMBL4555739)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529732(CHEMBL4527667)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529734(CHEMBL4532027)

IC50: 26nMAssay Description:Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce...More data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529734(CHEMBL4532027)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529745(CHEMBL4548659)

IC50: 27nMAssay Description:Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce...More data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529738(CHEMBL4514611)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529738(CHEMBL4514611)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529745(CHEMBL4548659)

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL

BDBM50241831(CHEMBL4062273 | US10626113, Compound M | US1089975...)

IC50: 30nMAssay Description:Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529740(CHEMBL4536719)

IC50: 30nMAssay Description:Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce...More data for this Ligand-Target Pair

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529740(CHEMBL4536719)

PDB MMDB Reactome pathway KEGG
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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL

BDBM50529749(CHEMBL4440110)

IC50: 33nMAssay Description:Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 349 total ) | Next | Last >>

Filter my 349 hits

Targets 2▿
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 296
- O43924/P16499/P18545/P35913/P51160/Q13956 53
Publications 24▿
- US Patent US10913710 (2021) 100
- J Med Chem 57: 5435-48 (2014) 53
- Eur J Med Chem 163: 597-609 (2019) 52
- J Med Chem 61: 2604-2610 (2018) 30
- J Med Chem 60: 9400-9406 (2017) 19
- Bioorg Med Chem Lett 13: 1425-8 (2003) 19
- J Med Chem 63: 7892-7905 (2020) 14
- ACS Med Chem Lett 13: 298-303 (2022) 14
- J Med Chem 49: 5363-71 (2006) 12
- J Med Chem 64: 9100-9119 (2021) 8
- J Med Chem 48: 3449-62 (2005) 5
- Eur J Med Chem 229: (2022) 4
- J Med Chem 62: 4370-4382 (2019) 3
- Bioorg Med Chem Lett 23: 4944-7 (2013) 3
- Eur J Med Chem 232: (2022) 2
- Bioorg Med Chem Lett 44: (2021) 2
- Bioorg Med Chem 56: (2022) 2
- J Med Chem 65: 7489-7531 (2022) 1
- J Med Chem 57: 6632-41 (2014) 1
- Bioorg Med Chem Lett 26: 4216-22 (2016) 1
- Bioorg Med Chem Lett 30: (2020) 1
- Bioorg Med Chem 27: 3440-3450 (2019) 1
- Bioorg Med Chem Lett 14: 1577-80 (2004) 1
- ACS Med Chem Lett 12: 302-308 (2021) 1
Institutions 20▿
- Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften 100
- Second Military Medical University 77
- Chinese Academy Of Sciences 55
- Max Planck Institute Of Molecular Physiology 53
- Pfizer 19
- Università 12
- Chiesi Farmaceutici 8
- Monash University (Parkville Campus) 5
- Central South University 4
- TBA 3
- Indian Institute Of Technology (B.H.U.) 2
- Shaoxing University 2
- Merck 2
- Mitsubishi Tanabe Pharma 1
- Janssen Research & Development 1
- Amgen 1
- Astrazeneca 1
- Changzhou University 1
- University College London 1
- Bristol-Myers Squibb Pharmaceutical Research Institute 1
Affinity: 0.077 to 1.0E+5 nM▿
- Ki 17
- IC50 112
- Kd 220
- Affinity ≤ nM
Xtal structures: 12
Docked structures: 0
Catalog Cmpds: 70