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Report error Found 132 of affinity data for UniProtKB/TrEMBL: O94760
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626264BDBM50626264(CHEMBL5423612)
Affinity DataKi:  190nMAssay Description:Inhibition of N-terminal His6-tagged human DDAH1 expressed in Escherichia coli BL21 DE3 cells using L-Nva as substrate assessed as L-citrulline forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519933BDBM50519933(CHEMBL4444007)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519933BDBM50519933(CHEMBL4444007)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate assessed as inhibition constant preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519934BDBM50519934(CHEMBL4461206)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519934BDBM50519934(CHEMBL4461206)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human DDAH1 transfected in HEK293T cells assessed as inhibition constant measured after 15 mins in presence of N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240715BDBM50240715((S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid ...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells assessed as inhibition constant measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240715BDBM50240715((S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid ...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human DDAH1 expressed using SMTC as substrate assessed as inhibition constant measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240715BDBM50240715((S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid ...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 235685BDBM235685(hDDAH inhibitor, 1a)
Affinity DataKi:  2.00E+3nM ΔG°:  -33.8kJ/molepH: 7.4 T: 2°CAssay Description:A colorimetric assay was carried out in 150 μL 50 mM potassium phosphate buffer pH 7.4 containing 4 μg of recombinant hDDAH-1 and varying c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240715BDBM50240715((S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid ...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human DDAH1 by plate-reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519933BDBM50519933(CHEMBL4444007)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155523BDBM155523(US9011882, Table 1, Compound 18)
Affinity DataIC50: 3.30E+3nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50389868BDBM50389868(CHEMBL2070857 | US9011882, Table 1, Compound 16)
Affinity DataIC50: 5.10E+3nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626259BDBM50626259(CHEMBL5437726)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate assessed as inhibition constant preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155517BDBM155517(US9011882, Table 1, Compound 10)
Affinity DataIC50: 7.10E+3nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92904BDBM92904(nNOS and DDAH inhibitor, 14)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2013
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626262BDBM50626262(CHEMBL1234051)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged human DDAH1 expressed in Escherichia coli Rosetta 2 DE3 cells assessed as inhibition constant by calorimetric as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155515BDBM155515(US9011882, Table 1, Compound 8)
Affinity DataIC50: 8.60E+3nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519932BDBM50519932(CHEMBL4449638)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565138BDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human DDAH1 using SMTC as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626268BDBM50626268(CHEMBL5427675)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of His-tagged human DDAH1 using SMTC as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155510BDBM155510(US9011882, Table 1, Compound 3)
Affinity DataIC50: 9.90E+3nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34513BDBM34513(N-[2-(2,5-dimethoxyphenyl)ethyl]-2-(4,6-dimethyl-3...)
Affinity DataIC50: 9.90E+3nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155521BDBM155521(US9011882, Table 1, Compound 14)
Affinity DataIC50: 1.05E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155519BDBM155519(US9011882, Table 1, Compound 12)
Affinity DataIC50: 1.10E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155522BDBM155522(US9011882, Table 1, Compound 17)
Affinity DataIC50: 1.18E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240715BDBM50240715((S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid ...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155516BDBM155516(US9011882, Table 1, Compound 9)
Affinity DataIC50: 1.28E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240959BDBM50240959((S)-2-Amino-5-[N'-(2-methoxy-ethyl)-guanidino]-pen...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of human DDAH1 by plate-reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 141899BDBM141899(hDDAH inhibitor, 2a | US8921421, L-257)
Affinity DataKi:  1.30E+4nM ΔG°:  -29.0kJ/molepH: 7.4 T: 2°CAssay Description:A colorimetric assay was carried out in 150 μL 50 mM potassium phosphate buffer pH 7.4 containing 4 μg of recombinant hDDAH-1 and varying c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240715BDBM50240715((S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid ...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human DDAH1 by plate-reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240959BDBM50240959((S)-2-Amino-5-[N'-(2-methoxy-ethyl)-guanidino]-pen...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 141899BDBM141899(hDDAH inhibitor, 2a | US8921421, L-257)
Affinity DataKi:  1.30E+4nM IC50: 2.90E+4nMpH: 7.4Assay Description:This assay was used to determine the inhibiting effect of the inhibitors in a concentration of 1 mM. A standard incubation mixture consisted of 75 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155508BDBM155508(US9011882, Table 1, Compound 1)
Affinity DataIC50: 1.31E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 46658BDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 1.32E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155520BDBM155520(US9011882, Table 1, Compound 13)
Affinity DataIC50: 1.34E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155514BDBM155514(US9011882, Table 1, Compound 7)
Affinity DataIC50: 1.37E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626258BDBM50626258(CHEMBL5410984)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate assessed as inhibition constant preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155518BDBM155518(US9011882, Table 1, Compound 11)
Affinity DataIC50: 1.41E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50254452BDBM50254452(N-omega-propargyl-L-arginine | CHEMBL197234)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells assessed as inhibition constant measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 235691BDBM235691(hDDAH inhibitor, 2e)
Affinity DataKi:  1.70E+4nM ΔG°:  -28.3kJ/molepH: 7.4 T: 2°CAssay Description:A colorimetric assay was carried out in 150 μL 50 mM potassium phosphate buffer pH 7.4 containing 4 μg of recombinant hDDAH-1 and varying c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50254452BDBM50254452(N-omega-propargyl-L-arginine | CHEMBL197234)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human DDAH1 by plate-reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155512BDBM155512(US9011882, Table 1, Compound 5)
Affinity DataIC50: 1.77E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626259BDBM50626259(CHEMBL5437726)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 141900BDBM141900(US8921421, 3)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 141900BDBM141900(US8921421, 3)
Affinity DataKi:  1.80E+4nM IC50: 7.00E+4nMpH: 7.4Assay Description:This assay was used to determine the inhibiting effect of the inhibitors in a concentration of 1 mM. A standard incubation mixture consisted of 75 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155511BDBM155511(US9011882, Table 1, Compound 4)
Affinity DataIC50: 2.12E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 155509BDBM155509(US9011882, Table 1, Compound 2)
Affinity DataIC50: 2.33E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240959BDBM50240959((S)-2-Amino-5-[N'-(2-methoxy-ethyl)-guanidino]-pen...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human DDAH1 by plate-reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255074BDBM50255074(N5-(1-iminobutyl)-L-ornithine | (S)-2-Amino-5-buty...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of human DDAH1 by plate-reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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