Compile Data Set for Download or QSAR
Report error Found 2579 of affinity data for UniProtKB/TrEMBL: P07858
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167289((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)
Affinity DataKi:  0.0770nMAssay Description:Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50284944(((S)-1-(S)-Oxiranyl-2-phenyl-ethyl)-carbamic acid ...)
Affinity DataKi:  0.0870nMAssay Description:Kinetic parameter (Ki 1/min) was evaluated for the inactivation of cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50602545(CHEMBL4596647)
Affinity DataIC50: 0.149nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 0.210nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167288((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)
Affinity DataKi:  0.25nMAssay Description:Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50602542(CHEMBL4594870)
Affinity DataIC50: 0.278nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335289(N-{4-[5-(2-Thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335279(N-(Benzyloxycarbonyl)-tyrosyl-methylazalanine-nitr...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50030745(CHEMBL3342185 | acs.jmedchem.1c00409_ST.412)
Affinity DataKi:  0.406nMAssay Description:Inhibition of human cathepsin B using Z-Arg-Arg-pNA chromogenic substrate fluorogenic substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50602544(CHEMBL4594757)
Affinity DataIC50: 0.416nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304794((S)-benzyl 1-(2-cyano-1,2-dimethylhydrazinyl)-4-me...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50030746(CHEMBL3342184 | acs.jmedchem.1c00409_ST.413)
Affinity DataKi:  0.459nMAssay Description:Inhibition of human cathepsin B using Z-Arg-Arg-pNA chromogenic substrate fluorogenic substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335278(N-(Benzyloxycarbonyl)-cyclohexylalanyl-methylazala...)
Affinity DataKi:  0.480nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM509972(Advanced SARS-CoV-2 Inhibitor 6e | acs.jmedchem.1c...)
Affinity DataIC50: 0.5nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM509973(Advanced SARS-CoV-2 Inhibitor 6j | acs.jmedchem.1c...)
Affinity DataIC50: 0.5nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335280(N-(Benzylcarbamoyl)-leucyl-methylazaalanine-nitril...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304793((S)-benzyl 1-(2-cyano-1,2-dimethylhydrazinyl)-1-ox...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510762(CHEMBL4442025)
Affinity DataKi:  0.690nMAssay Description:Inhibition of human liver cathepsin B using Z-Phe-Arg-AMC as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335277(N-(Benzyloxycarbonyl)-isoleucyl-methylazalanine-ni...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50290289((S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoyl...)
Affinity DataKi:  1nMAssay Description:Equilibrium dissociation constant for the inhibition of human cathepsin B was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50201701(cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3....)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335281(N-(Phenylcarbamoyl)-leucyl-methylazaalanine-nitril...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335283(N-{4-[5-(2-Thienyl)-1,2,4-oxadiazol-3-yl]benzylcar...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167290((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)
Affinity DataKi:  1.30nMAssay Description:Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataIC50: 1.53nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2009
Entry Details
PCBioAssay
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50201705((1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107639(3-{2-[2-(4-Chloro-2-fluoro-benzoylamino)-3-m-tolyl...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410979(CHEMBL207347)
Affinity DataKi:  2nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230555(CHEMBL5267078)
Affinity DataKi:  2nMAssay Description:Binding affinity to Cathepsin B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510761(CHEMBL4440655)
Affinity DataKi:  2nMAssay Description:Inhibition of human liver cathepsin B using Z-Phe-Arg-AMC as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM93204(Mercaptomethyl ketone Inhibitor, 53)
Affinity DataKi:  2nMpH: 5.5Assay Description:A fluorometric high-throughput assay for activity against cathepsin B was performed in 96-well microtiter plates. The assay were performed in Dynate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374367(CHEMBL271004)
Affinity DataKi:  2nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16509(CA074 | CHEMBL490920 | (2S)-1-[(2S,3S)-3-methyl-2-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16508((2S)-1-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335284(N-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)phenylcarbamoy...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335285(N-{4-[5-(2-Thienyl)-1,2,4-oxadiazol-3-yl]phenylcar...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against human cathepsin B using 10 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16509(CA074 | CHEMBL490920 | (2S)-1-[(2S,3S)-3-methyl-2-...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of cathepsin B in human SH-SY5Y cells using RR-AMC as substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335282(N-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzylcarbamoy...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50250153(3-acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-ni...)
Affinity DataIC50: 3.11nMAssay Description:Inhibition of human liver cathepsin B after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataKi:  3.36nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50030747(CHEMBL3342183)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human cathepsin B using Z-Arg-Arg-pNA chromogenic substrate fluorogenic substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50137736((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16509(CA074 | CHEMBL490920 | (2S)-1-[(2S,3S)-3-methyl-2-...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50065404((R)-N-((S)-5-Benzenesulfonylamino-1-formyl-pentyl)...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against cathepsin B receptor in human liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50137720((1S,5S,6R)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyr...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50135541(5-{(R)-2-Cyano-2-[(S)-2-(3-oxo-1,3-dihydro-isobenz...)
Affinity DataIC50: 4.10nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50335276(N-(Benzyloxycarbonyl)-valyl-methylazalanine-nitril...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
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