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Found 51 of affinity data for UniProtKB/TrEMBL: P16233
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50212744(CHEBI:35020 | TRIBUTYRIN)
Affinity DataKi: <1nM Kon:  1M-1s-1Assay Description:Tested for hydrolysis with 0.2 ug/mL of PPL (porcine pancreatic lipase), 1.5 ug/mL of colipase and 4 mM sodium taurodeoxycholatet (NaTDC) at a compou...More data for this Ligand-Target Pair
In DepthDetails
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50212746(CHEMBL119630)
Affinity DataKi:  220nM Kon:  220M-1s-1Assay Description:Tested for hydrolysis with 0.5 ug/mL of PPL (porcine pancreatic lipase), 1.5 ug/mL of colipase and 4 mM of sodium taurodeoxycholatet (NaTDC) at the c...More data for this Ligand-Target Pair
In DepthDetails
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50212746(CHEMBL119630)
Affinity DataKi:  710nM Kon:  710M-1s-1Assay Description:Tested for hydrolysis with 1.0 ug/mL of PPL (porcine pancreatic lipase), 2.2 ug/mL of colipase and 4 mM of sodium taurodeoxycholatet (NaTDC) at the c...More data for this Ligand-Target Pair
In DepthDetails
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50212744(CHEBI:35020 | TRIBUTYRIN)
Affinity DataKi:  1.10E+3nM Kon:  1.10E+3M-1s-1Assay Description:Tested for hydrolysis with 0.2 ug/mL of PPL (porcine pancreatic lipase) at a compound dose of 0.2 gMore data for this Ligand-Target Pair
In DepthDetails
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50212746(CHEMBL119630)
Affinity DataKi:  2.10E+3nM Kon:  2.10E+3M-1s-1Assay Description:Tested for hydrolysis with 0.2 ug/mL of PPL (porcine pancreatic lipase) at the compound dose of 0.2 gMore data for this Ligand-Target Pair
In DepthDetails
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50212746(CHEMBL119630)
Affinity DataKi:  5.70E+3nM Kon:  5.70E+3M-1s-1Assay Description:Tested for hydrolysis with 1.0 ug/mL of PPL (porcine pancreatic lipase)at the compound dose of 0.2 gMore data for this Ligand-Target Pair
In DepthDetails
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50381861(CHEMBL2022676)
Affinity DataKi:  6.70E+4nMAssay Description:Inhibition of human pancreatic lipase using p-nitrophenylbutyrate as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50381860(CHEMBL2022680)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of human pancreatic lipase using p-nitrophenylbutyrate as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50381859(CHEMBL2022681)
Affinity DataKi:  3.60E+5nMAssay Description:Inhibition of human pancreatic lipase using p-nitrophenylbutyrate as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50381858(CHEMBL2022679)
Affinity DataKi:  5.50E+5nMAssay Description:Inhibition of human pancreatic lipase using p-nitrophenylbutyrate as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human PL expressed in HEK293F cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  80.7nMAssay Description:Inhibition of pancreatic lipase assessed as umoles of oleic acic released per millimiter of triolein per hourMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  780nMAssay Description:Inhibition of PTL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  806nMAssay Description:Compound was tested for inhibition of porcine pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367145(CHEMBL4173252)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367138(CHEMBL4160519)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367133(CHEMBL4164998)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367134(CHEMBL4167341)
Affinity DataIC50:  1.87E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367211(CHEMBL4165339)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50569167(CHEMBL4847734)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of PTL (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367212(CHEMBL4168413)
Affinity DataIC50:  2.28E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367214(CHEMBL4163899)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50232349(CHEMBL4102155)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human pancreatic lipase using 4-methylumbelliferyl oleate as substrate after 30 mins by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50215413(CHEMBL360443)
Affinity DataIC50:  3.44E+3nMAssay Description:Compound was tested for inhibition of porcine pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50569165(CHEMBL4856331)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of PTL (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50569166(CHEMBL4860907)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of PTL (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50569168(CHEMBL4847071)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of PTL (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367213(CHEMBL4175223)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367216(CHEMBL4176621)
Affinity DataIC50:  7.38E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367135(CHEMBL4160094)
Affinity DataIC50:  7.82E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50232348(CHEMBL4077903)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human pancreatic lipase using 4-methylumbelliferyl oleate as substrate after 30 mins by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367143(CHEMBL4168757)
Affinity DataIC50:  9.15E+3nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50138739(4-tert-Butyl-N-[4-(5-methoxy-2-oxo-[1,3,4]oxadiazo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested to inhibit pancreatic lipase (PL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50138734(3-(3-(benzyloxy)phenyl)-5-ethoxy-1,3,4-oxadiazol-2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested to inhibit pancreatic lipase (PL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367136(CHEMBL4172103)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50213683(CHEMBL218693 | carnosol)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367215(CHEMBL4170734)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50367142(CHEMBL4161505)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50326047((6S,9R,12R)-1-((R)-1-((R)-2-((S)-1-((S)-5-amino-2-...)
Affinity DataIC50:  1.60E+4nMAssay Description:Binding affinity to pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50207385(CHEBI:6646 | Mahanimbine | Rel-(+)-Mahanimbine)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of pancreatic lipase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50213689((S)-2-((2E,8E)-deca-2,8-dienoylamino)-3-((S)-5-hyd...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50521226(CHEMBL4471545)
Affinity DataIC50: >3.70E+4nMAssay Description:Inhibition of recombinant human PL expressed in HEK293F cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50138751(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound was tested to inhibit pancreatic lipase (PL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50138737(3-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethylsulfan...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound was tested to inhibit pancreatic lipase (PL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50138735((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound was tested to inhibit pancreatic lipase (PL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50213686(2-((2E,8E)-deca-2,8-dienoylamino)-3-(5-hydroxy-6-o...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50207384(Koenimbine)
Affinity DataIC50:  1.69E+5nMAssay Description:Inhibition of pancreatic lipase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50213694((R)-2-((2E,8E)-deca-2,8-dienoylamino)-3-((R)-5-hyd...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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