Affinity DataKi: 120nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A5More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 190nMAssay Description:Competitive inhibition of human recombinant CYP3A5 expressed in baculovirus-infected insect cells using diltiazem as substrate incubated for 15 mins ...More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A5 measured by testosterone hydroxylationMore data for this Ligand-Target Pair
Affinity DataKi: 570nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A5 measured by testosterone hydroxylationMore data for this Ligand-Target Pair
Affinity DataKi: 829nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 855nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of testosterone 6beta-hydroxylase activity of human recombinant CYP3A5 in presence of human P450 oxidoreductase and b5 assessed as decreas...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of midazolam 1'-hydroxylase activity of human recombinant CYP3A5 harboring human P450 oxidoreductase and b5 assessed as decrease in enzyme...More data for this Ligand-Target Pair
Affinity DataKi: 2.69E+3nMAssay Description:Reversible competitive inhibition of human CYP3A5-mediated 1'-OH midazolam formation in human liver microsomes after 7.5 mins by nonlinear regression...More data for this Ligand-Target Pair
Affinity DataKi: 4.53E+3nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A5 measured by testosterone hydroxylationMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A5More data for this Ligand-Target Pair
Affinity DataKi: 3.76E+4nMAssay Description:Inhibition of human recombinant CYP3A5 using testosterone as substrate assessed as testosterone 6-beta-hydroxylation preincubated up to 30 mins with ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of CYP3A5 in doxycycline-induced CYP3A5 overexpressing wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation us...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of CYP3A5 in wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation using midazolam as substrate after 24 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: >50nMAssay Description:Inhibition of CYP3A5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of CYP3A5 in lentiviral pLVX-TRE3G-ZsGreen1-CYP3A5 transduced wild type human AsPC1 cells overexpressing CYP3A5 assessed as decrease in 1-...More data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Inhibition of CYP3A5 in CRISPR/Cas9-mediated CYP3A5 knock-out and doxycycline-induced CYP3A5 overexpressing human AsPC1 cells assessed as decrease in...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human CYP3A5 expressed in supersomes assessed inhibition of 1'-OH midazolam formation preincubated with compound before substrate addit...More data for this Ligand-Target Pair
Affinity DataIC50: 141nMAssay Description:Inhibition of CYP3A5 in doxycycline-induced CYP3A5 overexpressing wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation us...More data for this Ligand-Target Pair
Affinity DataIC50: 162nMAssay Description:Inhibition of CYP3A5 in CRISPR/Cas9-mediated CYP3A5 knock-out and doxycycline-induced CYP3A5 overexpressing human AsPC1 cells assessed as decrease in...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 439nMAssay Description:Inhibition of CYP3A5 in lentiviral pLVX-TRE3G-ZsGreen1-CYP3A5 transduced wild type human AsPC1 cells overexpressing CYP3A5 assessed as decrease in 1-...More data for this Ligand-Target Pair
Affinity DataIC50: 513nMAssay Description:Inhibition of CYP3A5 in wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation using midazolam as substrate after 24 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 556nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of human CYP3A5 expressed in supersomes assessed inhibition of 1'-OH midazolam formation by LC-MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 723nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 830nMAssay Description:Inhibition of CYP3A5 in human liver microsomes incubated for 5 mins in presence of NADPH and specific substrates by LC/MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant human CYP3A5 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human CYP3A5 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.34E+3nMAssay Description:Time dependent inhibition of recombinant human CYP3A5 using midazolam as substrate preincubated for 30 mins in presence of NADPH generating system fo...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.76E+3nMAssay Description:Time dependent inhibition of recombinant human CYP3A5 incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysisMore data for this Ligand-Target Pair
