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Report error Found 6310 of affinity data for UniProtKB/TrEMBL: P27487
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM15526(N-{[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrol...)
Affinity DataAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50296490((7R,8R)-8-(2,4,5-Trifluoro-phenyl)-6,7,8,9-tetrahy...)
Affinity DataEC50:  112nMAssay Description:Inhibition of human DPP4 activity by continuous fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50198181(CHEMBL3941804)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM420962(US10479798, Compound 21)
Affinity DataKd:  0.177nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataKd:  12.7nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50391565(CHEMBL2147777 | US20240115577, Compound 8)
Affinity DataKd:  12nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50534424(CHEMBL4456228)
Affinity DataKd:  806nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228409(8-(3-aminopiperidin-1-yl)-7-benzyl-1,3-dimethyl-1H...)
Affinity DataKd:  13nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228397(CHEMBL237067 (9) | CHEMBL237067 | 8-((S)-3-amino-p...)
Affinity DataKd:  0.420nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataKd:  16nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataKd:  29nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50534424(CHEMBL4456228)
Affinity DataKd:  246nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228409(8-(3-aminopiperidin-1-yl)-7-benzyl-1,3-dimethyl-1H...)
Affinity DataKd:  19nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228397(CHEMBL237067 (9) | CHEMBL237067 | 8-((S)-3-amino-p...)
Affinity DataKd:  9.20nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataKd:  0.00660nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50391565(CHEMBL2147777 | US20240115577, Compound 8)
Affinity DataKd:  0.410nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKd:  11nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataKd:  14nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50543535(CHEMBL4632639)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to DPP4 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50198186(CHEMBL3944427 | US10479798, Compound 19)
Affinity DataKd:  11nMAssay Description:Binding affinity to DPP4 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataKd:  12.7nMAssay Description:Binding affinity to DPP4 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50198181(CHEMBL3941804)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to DPP4 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50221967((2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-((S)-...)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50612314(CHEMBL5279548)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM205995(US9255098, Ex. 1 | US9255098, Ex. 4)
Affinity DataIC50: 0.0500nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50221977((2S,3S)-2-amino-3-(4'-fluorobiphenyl-4-yl)-1-((S)-...)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM205995(US9255098, Ex. 1 | US9255098, Ex. 4)
Affinity DataIC50: 0.0800nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM408611(US10358449, Compound I-3)
Affinity DataIC50: 0.0800nMAssay Description:DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce glow type luminescent signals in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50611802(CHEMBL5269668)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-7-amido-4-methylcoumarin as substrate incubated for 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM205996(US9255098, Ex. 2 | US9255098, Ex. 5)
Affinity DataIC50: 0.100nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50151798([6-(2,4-Dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory concentration against Dipeptidyl peptidase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human C-terminal step-tagged DPP4 expressed using baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of dipeptidyl peptidase 4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50516930(CHEMBL4448186 | US20240115577, Compound 20)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50170939(CHEMBL3806052)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50166319(4-[(3S,5S)-5-((S)-2-Cyano-pyrrolidine-1-carbonyl)-...)
Affinity DataIC50: 0.130nMAssay Description:Inhibitory concentration against human dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM50166318((S)-1-[(2S,4S)-4-(3-Chloro-4-cyano-phenylamino)-py...)
Affinity DataIC50: 0.130nMAssay Description:Inhibitory concentration against human dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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