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TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526811BDBM50526811(Kzr-616)
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of 20S proteasome beta 5i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554394BDBM50554394(CHEMBL4784875)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554392BDBM50554392(CHEMBL4751044)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476098BDBM50476098(Cinnabaramide G)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554397BDBM50554397(CHEMBL4741140)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50234982BDBM50234982(CHEMBL4102324)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604290BDBM50604290(CHEMBL5175132)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50476095BDBM50476095(CINNABARAMIDE A)
Affinity DataIC50: 1nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50234984BDBM50234984(CHEMBL3218837)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of 20S immunoproteasome beta 5i subunit in human peripheral blood monocyte using Ac-ANW-AMC as substrate in presence of PA28alpha by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604328BDBM50604328(CHEMBL5180795)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099832BDBM50099832(CHEMBL3319587)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554389BDBM50554389(CHEMBL4796570)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604287BDBM50604287(CHEMBL5201806)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50398608BDBM50398608(MARIZOMIB)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of 20S proteasome (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550643BDBM50550643(CHEMBL4749207)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069989BDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099830BDBM50099830(CHEMBL3319585)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554385BDBM50554385(CHEMBL4764897)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50531806BDBM50531806(CHEMBL4460323)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554386BDBM50554386(CHEMBL4758484)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601642BDBM50601642(CHEMBL5188533)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604327BDBM50604327(CHEMBL5202276)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388435BDBM388435(US10294246, Compound No. 132)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601652BDBM50601652(CHEMBL5191857)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388321BDBM388321(US10294246, Compound No. 18)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604289BDBM50604289(CHEMBL5181060)
Affinity DataIC50: 2nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069989BDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50031442BDBM50031442(Alpha-ketocarbonyl derivative | 1N-[4-amino(nitroi...)
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099659BDBM50099659(CHEMBL3319478)
Affinity DataIC50: 2nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388309BDBM388309(US10294246, Compound No. 6)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099831BDBM50099831(CHEMBL3319586)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388395BDBM388395(US10294246, Compound No. 92)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388323BDBM388323(US10294246, Compound No. 20)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554384BDBM50554384(CHEMBL4784015)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388311BDBM388311(US10294246, Compound No. 8)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554395BDBM50554395(CHEMBL4763116)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50531814BDBM50531814(CHEMBL4517600)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514365BDBM50514365(CHEMBL4587036)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099663BDBM50099663(CHEMBL3319482)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604330BDBM50604330(CHEMBL5207139)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388437BDBM388437(US10294246, Compound No. 134)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604324BDBM50604324(CHEMBL5183361)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398609BDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604288BDBM50604288(CHEMBL5205273)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of 20S proteasome subunit beta-5i (unknown origin) using Ac-ANW-AMC as substrate and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099685BDBM50099685(CHEMBL3319578)
Affinity DataIC50: 3nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099829BDBM50099829(CHEMBL3319584)
Affinity DataIC50: 3nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329819BDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 20S proteasome beta 5i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388408BDBM388408(US10294246, Compound No. 105)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099660BDBM50099660(CHEMBL3319479)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 388428BDBM388428(US10294246, Compound No. 125)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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