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Found 2220 for UniProtKB: P49354
LigandPNGBDBM50287709((E)-3-Carboxy-2-(16-sulfooxy-hexadecyl)-pent-2-ene...)
Affinity DataKi:  4.5nMAssay Description:In vitro inhibition of human recombinant Protein farnesyltransferase with respect to FPPMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50492066(CHEMBL2396761)
Affinity DataKi:  5nMAssay Description:Inhibition of FTase (unknown origin)-mediated K-Ras4B model peptide KKKKKKSK(Dans)TKCVIM farnesylation by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50059860(((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...)
Affinity DataKi:  5.20nMAssay Description:Inhibitory activity against farnesyl pyrophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50143597((S)-2-(2-[2-(4-Fluoro-phenyl)-ethyl]-5-{[(1S,4S)-4...)
Affinity DataKi:  8nMAssay Description:Inhibition binding constant against Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50492066(CHEMBL2396761)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant FTase (unknown origin)-mediated K-Ras4B model peptide KKKKKKSK(Dans)TKCVIM farnesylation by fluorescence plate reader analy...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50289150(Acetic acid (7E,11E)-(1S,2R,4R,14S,15R)-4,8,12-tri...)
Affinity DataKi:  170nMAssay Description:Kinetic parameter for inihibiton of farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50481616(CHEMBL590127)
Affinity DataKi:  230nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50481625(CHEMBL599795)
Affinity DataKi:  260nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50481615(CHEMBL590126)
Affinity DataKi:  500nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50108070(2-[4-(2-Amino-3-mercapto-propylamino)-benzoylamino...)
Affinity DataKi:  785nMAssay Description:Inhibition of recombinant FTase (unknown origin)-mediated K-Ras4B model peptide KKKKKKSK(Dans)TKCVIM farnesylation by fluorescence plate reader analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059865(4,8,12-trimethyl-(3E,7E)-3,7,11-tridecatrienylhydr...)
Affinity DataKi:  830nMAssay Description:Inhibitory activity against farnesyl pyrophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50492065(CHEMBL2396762)
Affinity DataKi:  837nMAssay Description:Inhibition of recombinant FTase (unknown origin)-mediated K-Ras4B model peptide KKKKKKSK(Dans)TKCVIM farnesylation by fluorescence plate reader analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50108076((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of FTase (unknown origin)-mediated K-Ras4B model peptide KKKKKKSK(Dans)TKCVIM farnesylation by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50481616(CHEMBL590127)
Affinity DataKi:  5.60E+3nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50481616(CHEMBL590127)
Affinity DataKi:  7.70E+3nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50481615(CHEMBL590126)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50481615(CHEMBL590126)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14023((1R,2R,5R)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of human recombinant FTase using [3H]farnesyldiphosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135360(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataIC50:  0.0360nMAssay Description:In vitro inhibitory activity against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50520989(CHEMBL4565280)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human recombinant FTase using [3H]FPP as substrate after 15 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50126028(3',5'-Dichloro-6-[3-(4-cyano-phenyl)-3-hydroxy-3-(...)
Affinity DataIC50:  0.0790nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139186(4-allyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50495912(CHEMBL3115255)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50495899(CHEMBL3115256)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075841((S)-2-[(5-{2-[4-(Adamantane-1-carbonyl)-pyridin-3-...)
Affinity DataIC50:  0.120nMAssay Description:Inhibitory activity against farnesyltransferase (FT) using SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130373(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.120nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079974((S)-2-[2-({(S)-3-Methyl-2-[2-(3-naphthalen-1-ylmet...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079961((S)-2-[2-({(S)-3-Methyl-2-[2-(3-naphthalen-2-ylmet...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50:  0.123nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072639((S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylami...)
Affinity DataIC50:  0.123nMAssay Description:Inhibition of [3H]- FPP incorporation into recombinant Ha-Ras by farnesyl transferase at 10 pMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075837((S)-2-({5-[2-(3H-Imidazol-4-yl)-ethyl]-2'-methyl-b...)
Affinity DataIC50:  0.150nMAssay Description:Inhibitory activity against farnesyltransferase (FT) using SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369443(CHEMBL252953)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079956((S)-2-[2-({(S)-2-[2-(3-Benzyl-3H-imidazol-4-yl)-ac...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079966((S)-2-{2-[((S)-3-Methyl-2-{2-[3-(4-nitro-benzyl)-3...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115916(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130374(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.180nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Globe Pharmaceutical R And Abbott Laboratories

LigandPNGBDBM13390(4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...)
Affinity DataIC50:  0.190nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130381(4-[Amino-(3-methyl-3H-imidazol-4-yl)-methyl]-2-[3-...)
Affinity DataIC50:  0.190nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130365(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.190nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50098037(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against human Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50495906(CHEMBL3115258)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50075851((S)-2-{[5-(2-Imidazol-1-yl-vinyl)-2'-methyl-biphen...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against farnesyltransferase (FT) using SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075861((S)-2-{[5-(2-Imidazol-1-yl-ethyl)-2'-methyl-biphen...)
Affinity DataIC50:  0.210nMAssay Description:Inhibitory activity against farnesyltransferase (FT) using SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139202(4-methyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacycl...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126035(4-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imi...)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075844((S)-2-({5-[2-((E)-4-Hydroxy-pyridin-3-yl)-vinyl]-2...)
Affinity DataIC50:  0.290nMAssay Description:Inhibitory activity against farnesyltransferase (FT) using SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)
Affinity DataIC50:  0.290nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in cultured Ha-ras transformed RAT1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075842((S)-2-({5-[2-((E)-4-Chloro-pyridin-3-yl)-vinyl]-2'...)
Affinity DataIC50:  0.290nMAssay Description:Inhibitory activity against farnesyltransferase (FT) using SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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