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Found 2616 for UniProtKB: P54750
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nM ΔG°:  -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.400nM ΔG°:  -54.5kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  0.5nM ΔG°:  -54.0kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  0.5nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  1nM ΔG°:  -52.2kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50225506(CHEMBL150093)
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataKi:  9.50E+3nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50362048(CHEMBL1940058)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE1A3 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225509(Oxagrelate | SC-32840)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50362047(CHEMBL1940057)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE1A3 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50362046(CHEMBL1940056)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE1A3 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50362043(CHEMBL1940053)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE1A3 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50362036(CHEMBL1939915)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE1A3 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50362033(CHEMBL1939912)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE1A3 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50362035(CHEMBL1939914)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE1A3 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059033((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225507(CHEMBL151056)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027177(Cilostamide)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225504(EHT-0202 | Etazolate | SQ-20009)
Affinity DataKi:  6.00E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of sheep lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225505(CHEMBL358641 | ICI-58301)
Affinity DataKi:  7.17E+5nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of sheep lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM580557(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1- methylimida...)
Affinity DataIC50:  0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM501502(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[1- methylimidaz...)
Affinity DataIC50:  0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50:  0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50:  0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50:  0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50:  0.140nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50:  0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM528351(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-3- ethyl...)
Affinity DataIC50:  0.214nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50:  0.260nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM501512(1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)me...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM528352(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-isopropy...)
Affinity DataIC50:  0.260nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM528349(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-2,3- dim...)
Affinity DataIC50:  0.343nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.350nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM501501(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl...)
Affinity DataIC50:  0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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