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Report error Found 308 of affinity data for UniProtKB/TrEMBL: Q04760
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126960BDBM50126960(CHEMBL3629116)
Affinity DataKi:  0.300nMAssay Description:Inhibition of 6-His tagged recombinant human glyoxalase 1 transfected in Escherichia coli BL21 (DE3) assessed as S-D-lactoylglutathione formation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526945BDBM50526945(CHEMBL4473806)
Affinity DataKi:  0.960nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Michaelis-Menten analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126961BDBM50126961(CHEMBL3629115)
Affinity DataKi:  1nMAssay Description:Inhibition of 6-His tagged recombinant human glyoxalase 1 transfected in Escherichia coli BL21 (DE3) assessed as S-D-lactoylglutathione formation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526943BDBM50526943(CHEMBL4436073)
Affinity DataKi:  1nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50140172BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataKi:  5nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526944BDBM50526944(CHEMBL4450158)
Affinity DataKi:  7nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526942BDBM50526942(CHEMBL4438930)
Affinity DataKi:  10nMAssay Description:Inhibition of human Glyoxalase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402202BDBM50402202(CHEMBL2203964)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402202BDBM50402202(CHEMBL2203964)
Affinity DataKi:  11nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092825BDBM50092825(S-(N-phenyl-N-hydroxycarbamoyl)glutathione | CHEMB...)
Affinity DataKi:  14nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402204BDBM50402204(CHEMBL2203978)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092826BDBM50092826(S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione |...)
Affinity DataKi:  14nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092826BDBM50092826(S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione |...)
Affinity DataKi:  14nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50039111BDBM50039111(S-(N-Hydroxy-N-(4-bromophenyl)carbamoyl)glutathion...)
Affinity DataKi:  14nMAssay Description:Tested for inhibitory activity against human erythrocyte glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092826BDBM50092826(S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione |...)
Affinity DataKi:  14nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092827BDBM50092827(S-(N-hexyl-N-hydroxycarbamoyl)glutathione | CHEMBL...)
Affinity DataKi:  16nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092831BDBM50092831(S-(N-heptyl-N-hydroxycarbamoyl)glutathione | CHEMB...)
Affinity DataKi:  18nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526948BDBM50526948(CHEMBL4559486)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402206BDBM50402206(CHEMBL2203976)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092824BDBM50092824(S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione ...)
Affinity DataKi:  46nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092824BDBM50092824(S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione ...)
Affinity DataKi:  46nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092824BDBM50092824(S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione ...)
Affinity DataKi:  46nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126957BDBM50126957(CHEMBL3629119)
Affinity DataKi:  46nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092824BDBM50092824(S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione ...)
Affinity DataKi:  46nMAssay Description:Competitive inhibition of GLO1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50039108BDBM50039108(S-(N-Hydroxy-N-(4-chlorophenyl)carbamoyl)glutathio...)
Affinity DataKi:  46nMAssay Description:Tested for inhibitory activity against human erythrocyte glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241121BDBM50241121(S-p-bromobenzyl glutatione | S-p-bromobenzylglutat...)
Affinity DataKi:  80nMAssay Description:Inhibition of GLO1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126958BDBM50126958(CHEMBL3629118)
Affinity DataKi:  130nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092825BDBM50092825(S-(N-phenyl-N-hydroxycarbamoyl)glutathione | CHEMB...)
Affinity DataKi:  160nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092825BDBM50092825(S-(N-phenyl-N-hydroxycarbamoyl)glutathione | CHEMB...)
Affinity DataKi:  160nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50039113BDBM50039113(S-(N-Hydroxy-N-phenylcarbamoyl)glutathione)
Affinity DataKi:  160nMAssay Description:Tested for inhibitory activity against human erythrocyte glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092830BDBM50092830(S-(N-pentyl-N-hydroxycarbamoyl)glutathione | CHEMB...)
Affinity DataKi:  170nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241121BDBM50241121(S-p-bromobenzyl glutatione | S-p-bromobenzylglutat...)
Affinity DataKi:  170nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) using GSH and MGO as substrates preincubated with substrates for 6 mins followed by enzyme addition by sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092822BDBM50092822(S-(N-butyl-N-hydroxycarbamoyl)glutathione | CHEMBL...)
Affinity DataKi:  180nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517464BDBM50517464(CHEMBL1234300)
Affinity DataKi:  230nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402207BDBM50402207(CHEMBL2203975)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402203BDBM50402203(CHEMBL2203963)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402208BDBM50402208(CHEMBL2203974)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402201BDBM50402201(CHEMBL2203965)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402200BDBM50402200(CHEMBL2203966)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126959BDBM50126959(CHEMBL3629117)
Affinity DataKi:  330nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517468BDBM50517468(CHEMBL4559294)
Affinity DataIC50: 370nMAssay Description:Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517488BDBM50517488(CHEMBL4516514)
Affinity DataIC50: 460nMAssay Description:Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402205BDBM50402205(CHEMBL2203977)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517469BDBM50517469(CHEMBL4543065)
Affinity DataIC50: 480nMAssay Description:Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517474BDBM50517474(CHEMBL4539074)
Affinity DataIC50: 500nMAssay Description:Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402199BDBM50402199(CHEMBL2203967)
Affinity DataIC50: 510nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517465BDBM50517465(CHEMBL4457949)
Affinity DataIC50: 540nMAssay Description:Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 15236BDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant human His-tagged glyoxalase 1 expressed in Escherichia coli BL21 assessed as formation of S-D-lactoylglutathione after 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetLactoylglutathione lyase(Human)
Chengdu University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 15236BDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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