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Report error Found 194 of affinity data for UniProtKB/TrEMBL: Q13177
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataKd:  0.320nMAssay Description:Binding affinity to human PAK2 (P151 to R525 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PAK2 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181451(CHEMBL3818265)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human PAK2 using RRRLSFAEPG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  3.10nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  3.10nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  3.10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human PAK2 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50182399(CHEMBL3818479)
Affinity DataKi:  4.60nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human PAK2 (3-end residues) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181452(CHEMBL3819118)
Affinity DataKi:  9.5nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length PAK2 (unknown origin) assessed s reduction in substrate phosphorylation using peptide as substrate by FRET based Z-LYTE kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataKi:  11nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 12.8nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PAK2 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 19nMAssay Description:Inhibition of PAK2 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50182294(CHEMBL3817984)
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50182402(CHEMBL3819447)
Affinity DataKi:  39nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 40nMAssay Description:Inhibition of PAK2 (unknown origin) by Z'-LYTE functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 40nMAssay Description:Inhibition of full length PAK2 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 41nMAssay Description:Inhibition of human PAK2 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  43nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  43nMAssay Description:Binding affinity to PAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50148931(CHEMBL3770186)
Affinity DataKi:  48nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50434330(CHEMBL2386715)
Affinity DataIC50: 64nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50434331(CHEMBL2386717)
Affinity DataIC50: 71nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKd:  79nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50434332(CHEMBL2386716)
Affinity DataIC50: 133nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 190nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 190nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50649084(CHEMBL5619359)
Affinity DataIC50: 193nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50434333(CHEMBL2386718)
Affinity DataIC50: 244nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataKd:  270nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  340nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112348(CHEMBL3609372)
Affinity DataKd:  400nMAssay Description:Binding affinity to PAK2 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50652950(CHEMBL5687053)
Affinity DataKd:  400nMAssay Description:Binding affinity to PAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609598(CHEMBL5274607)
Affinity DataIC50: 824nMAssay Description:Inhibition of human recombinant full length PAK2 assessed as phosphorylation FRET peptide substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50182404(CHEMBL3819371)
Affinity DataKi:  940nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50: 970nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50564348(CHEMBL4780410)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of PAK2 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112352(CHEMBL3609371)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to PAK2 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50652949(CHEMBL5687001)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to PAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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