Compile Data Set for Download or QSAR
maximum 50k data
Found 66 of affinity data for UniProtKB/TrEMBL: Q16535
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50388626(CHEMBL2059435 | US9296736, 152 | US9593129, Exampl...)
Affinity DataIC50:  760nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50025671(CHEMBL583413)
Affinity DataIC50:  1.00E+3nMAssay Description:Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50:  1.00E+3nMAssay Description:Activity at p53 in human HCT116 cells expressing wild type p53 assessed as induction of p21 mRNA expression after 7 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397772(CHEMBL2177191 | US9296736, 185 | US9593129, Exampl...)
Affinity DataIC50:  1.50E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of doxorubicin-stimulated p53 (unknown origin) expressed in human RKO cells preincubated for 24 hrs followed by addition of doxorubicin fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397774(CHEMBL2177189 | US9296736, 128)
Affinity DataIC50:  1.60E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50:  1.90E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50540081(CHEMBL4438921)
Affinity DataIC50:  3.00E+3nMAssay Description:Activation of p53 in human SMMC7721 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50025671(CHEMBL583413)
Affinity DataIC50:  3.00E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM118299(US8653092, 67)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of p53 in human HCT116 cells assessed as reduction in nutlin-induced p53 transcriptional response by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397775(CHEMBL2177188)
Affinity DataIC50:  3.10E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50:  4.30E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397773(CHEMBL2177190)
Affinity DataIC50:  5.50E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50080451(CHEMBL3422267)
Affinity DataIC50:  6.20E+3nMAssay Description:Induction of p53-dependent growth suppression of human LNZTA3 cells after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50080457(CHEMBL3422268)
Affinity DataIC50:  6.20E+3nMAssay Description:Induction of p53-dependent growth suppression of human LNZTA3 cells after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299820((+/-)-syn-6,7-Bis(4-bromophenyl)-1-ethoxy-12-methy...)
Affinity DataIC50:  6.50E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50:  7.10E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299822((+/-)-syn-6,7-Bis(4-chlorophenyl)-12-methyl-7,12-d...)
Affinity DataIC50:  9.37E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50436459(CHEMBL2396661)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p53 (unknown origin) phosphorylation at Ser15 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397777(CHEMBL2177186 | US9593129, Example 3)
Affinity DataIC50:  1.07E+4nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299818((+/-)-syn-6,7-Bis(4-bromophenyl)-3-fluoro-2,12-dim...)
Affinity DataIC50:  1.14E+4nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299821((+/-)-syn-7-(4-Bromophenyl)-6-(4-chlorophenyl)-12-...)
Affinity DataIC50:  1.50E+4nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397778(CHEMBL2177813 | US9593129, Example 35)
Affinity DataIC50:  3.44E+4nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299819((+/-)-syn-6,7-Bis(4-bromophenyl)-2-fluoro-12-methy...)
Affinity DataIC50:  4.43E+4nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50403663(CHEMBL4164612)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to 15N-labeled T-p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C41 by HSQC...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50403664(CHEMBL4168664)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50403665(CHEMBL1235116)
Affinity DataKd:  1.40E+5nMAssay Description:Binding affinity to p53 Y220C mutant (unknown origin)More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50403666(CHEMBL4160358)
Affinity DataKd:  3.06E+5nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404068(CHEMBL4175464)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404069(CHEMBL4161418)
Affinity DataKd:  1.39E+5nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404075(CHEMBL4176523)
Affinity DataKd:  7.00E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404078(CHEMBL4172014)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to 15N-labeled T-p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C41 by HSQC...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404079(CHEMBL4165245)
Affinity DataKd:  2.10E+4nMAssay Description:Binding affinity to p53 Y220C mutant (unknown origin)More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404080(CHEMBL1232243)
Affinity DataKd:  8.20E+5nMAssay Description:Binding affinity to p53 Y220C mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50403663(CHEMBL4164612)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404081(CHEMBL4168439)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404082(CHEMBL4176302)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404083(CHEMBL4171798)
Affinity DataKd:  1.16E+5nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404084(CHEMBL4161192)
Affinity DataKd:  7.26E+5nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404087(CHEMBL4175243)
Affinity DataKd:  1.08E+5nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404088(CHEMBL4160123)
Affinity DataKd:  3.30E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404092(CHEMBL4168045)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404093(CHEMBL4163490)
Affinity DataKd:  6.30E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404095(CHEMBL4171387)
Affinity DataKd:  1.22E+5nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404096(CHEMBL4170894)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to p53 Y220C mutant (unknown origin)More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404456(CHEMBL4168268)
Affinity DataKd:  1.13E+5nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404457(CHEMBL4164831)
Affinity DataKd:  5.00E+4nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50404458(CHEMBL4162051)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity to N-terminal His6-tagged p53 DNA binding domain Y220C mutant (94 to 312 residues) (unknown origin) expressed in Escherichia coli C4...More data for this Ligand-Target Pair
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