Compile Data Set for Download or QSAR
maximum 50k data
Found 185 of affinity data for UniProtKB/TrEMBL: Q8IWU9
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50233990(CHEMBL4104957)
Affinity DataIC50:  7nMAssay Description:Inhibition of TPH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445676(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)
Affinity DataIC50:  11nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445676(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)
Affinity DataIC50:  11nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445677(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)
Affinity DataIC50:  14nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357737(KM-05-166/(I-206) | US10214530, Example 24)
Affinity DataIC50:  14nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445677(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)
Affinity DataIC50:  14nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357735(KM-05-193/(I-209) | US10214530, Example 27)
Affinity DataIC50:  14nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357735(KM-05-193/(I-209) | US10214530, Example 27)
Affinity DataIC50:  14nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357737(KM-05-166/(I-206) | US10214530, Example 24)
Affinity DataIC50:  14nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445685(Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...)
Affinity DataIC50:  15nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445685(Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...)
Affinity DataIC50:  15nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445680(Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...)
Affinity DataIC50:  16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445694(Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...)
Affinity DataIC50:  16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445694(Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...)
Affinity DataIC50:  16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445680(Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...)
Affinity DataIC50:  16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445672(Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445669(Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445672(Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445669(Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445696(Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445692(Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445696(Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445692(Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...)
Affinity DataIC50:  17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445670(Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...)
Affinity DataIC50:  18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445675(Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...)
Affinity DataIC50:  18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445675(Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...)
Affinity DataIC50:  18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445670(Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...)
Affinity DataIC50:  18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357739(AG-01-128/(I-202) | US10214530, Example 18)
Affinity DataIC50:  19nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50598894(CHEMBL5197055)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50598895(CHEMBL5172829)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357739(AG-01-128/(I-202) | US10214530, Example 18)
Affinity DataIC50:  20nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357734(KM-05-185/(I-204) | US10214530, Example 21)
Affinity DataIC50:  20nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50:  20nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50:  20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445671(Ex. 9/KM-06-89/(I-9) | US10683309, Example 9 | US1...)
Affinity DataIC50:  20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445674(Ex. 12/KM-06-93/(I-12) | US10683309, Example 12 | ...)
Affinity DataIC50:  20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50:  20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445671(Ex. 9/KM-06-89/(I-9) | US10683309, Example 9 | US1...)
Affinity DataIC50:  20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445674(Ex. 12/KM-06-93/(I-12) | US10683309, Example 12 | ...)
Affinity DataIC50:  20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445681(Ex. 17/KM-06-98/(I-17) | US10683309, Example 17 | ...)
Affinity DataIC50:  21nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445681(Ex. 17/KM-06-98/(I-17) | US10683309, Example 17 | ...)
Affinity DataIC50:  21nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445693(Ex. 29/KM-06-149/(I-29) | US10683309, Example 29 |...)
Affinity DataIC50:  23nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445693(Ex. 29/KM-06-149/(I-29) | US10683309, Example 29 |...)
Affinity DataIC50:  23nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445684(Ex. 20/KM-06-107/(I-20) | US10683309, Example 20 |...)
Affinity DataIC50:  24nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445684(Ex. 20/KM-06-107/(I-20) | US10683309, Example 20 |...)
Affinity DataIC50:  24nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445691(Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...)
Affinity DataIC50:  25nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445691(Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...)
Affinity DataIC50:  25nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445703(Ex. 39/KM-06-180/(I-39) | US10683309, Example 39 |...)
Affinity DataIC50:  26nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM445703(Ex. 39/KM-06-180/(I-39) | US10683309, Example 39 |...)
Affinity DataIC50:  26nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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