Compile Data Set for Download or QSAR
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Found 121 for UniProtKB: Q9QUK6
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50155929(CHEMBL225157 | TAK-242)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of TLR4 in LPS/INFgamma stimulated mouse peritoneal macrophages assessed as inhibition of IL1-beta after 20 hrs by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50029089(CHEMBL3360821)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391678(CHEMBL1569494)
Affinity DataIC50:  310nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391682(CHEMBL2148167)
Affinity DataIC50:  330nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391691(CHEMBL2148182)
Affinity DataIC50:  410nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391678(CHEMBL1569494)
Affinity DataIC50:  420nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of IL1-beta production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391683(CHEMBL2148176)
Affinity DataIC50:  420nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391690(CHEMBL2148181)
Affinity DataIC50:  520nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50029088(CHEMBL3360820)
Affinity DataIC50:  600nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391674(CHEMBL2148171)
Affinity DataIC50:  710nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLymphocyte antigen 96/Toll-like receptor 4(Mus musculus)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50501802(CHEMBL4544533)
Affinity DataIC50:  730nMAssay Description:Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced IL-6 production preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391687(CHEMBL2148169)
Affinity DataIC50:  740nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50029087(CHEMBL3360819)
Affinity DataIC50:  800nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391679(CHEMBL2148166)
Affinity DataIC50:  820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391693(CHEMBL2148177)
Affinity DataIC50:  820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391692(CHEMBL2148170)
Affinity DataIC50:  820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391686(CHEMBL2148168)
Affinity DataIC50:  820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391684(CHEMBL2148183)
Affinity DataIC50:  930nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089805(CHEMBL3577590)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391676(CHEMBL2148174)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391675(CHEMBL2148173)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089824(CHEMBL3577592)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089806(CHEMBL3577591)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391673(CHEMBL2148184)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391680(CHEMBL2148172)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391678(CHEMBL1569494)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of TNFalpha production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089803(CHEMBL3577589)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089804(CHEMBL3576878)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089831(CHEMBL3577593)
Affinity DataIC50:  1.80E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391694(CHEMBL2148178)
Affinity DataIC50:  2.13E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391688(CHEMBL2148179)
Affinity DataIC50:  2.53E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089802(CHEMBL3577588)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391681(CHEMBL2148175)
Affinity DataIC50:  3.11E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50029086(CHEMBL3360816)
Affinity DataIC50:  3.30E+3nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391689(CHEMBL2148180)
Affinity DataIC50:  3.72E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50391695(CHEMBL2148187)
Affinity DataIC50:  4.53E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089785(CHEMBL3577579)
Affinity DataIC50:  5.20E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089843(CHEMBL3577594)
Affinity DataIC50:  5.70E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089801(CHEMBL3577587)
Affinity DataIC50:  6.70E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50089800(CHEMBL3577586)
Affinity DataIC50:  7.50E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50355889(CHEMBL1910032)
Affinity DataIC50:  1.29E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in thioglycollate-elicited mouse peritoneal macrophages assessed as inhibition of IL-6 production after 18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50351543(CHEMBL1824696)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50351544(CHEMBL1821757)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50351543(CHEMBL1824696)
Affinity DataIC50:  1.61E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50351545(CHEMBL1824689)
Affinity DataIC50:  1.65E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50180857(CHEMBL3818998)
Affinity DataIC50:  1.85E+4nMAssay Description:Agonist activity at TLR4 in C57BL/6J mouse macrophages assessed as stimulation of TNFalpha release after 4 hrs by ELISAMore data for this Ligand-Target Pair
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50351546(CHEMBL1824688)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50351548(CHEMBL1824697)
Affinity DataIC50:  2.01E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50180858(CHEMBL3819171)
Affinity DataIC50:  2.07E+4nMAssay Description:Agonist activity at TLR4 in C57BL/6J mouse macrophages assessed as stimulation of TNFalpha release after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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