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Found 320 of affinity data for UniProtKB/TrEMBL: Q9QUR5
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM82071(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50094703(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM194954(US9206198, 7)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of rat Kir1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM350315(US10208064, Example 30)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155924(US9018211, 5)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155921(US9018211, 2A)
Affinity DataIC50:  9nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM350282(US10208064, Example 2)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155923(US9018211, 2C)
Affinity DataIC50:  10nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM350300(US10208064, Example 19)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162868(US9056859, 11)
Affinity DataIC50:  12nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155922(US9018211, 2B)
Affinity DataIC50:  12nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155925(US9018211, 12)
Affinity DataIC50:  13nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155926(US9018211, 20)
Affinity DataIC50:  14nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50:  14nMAssay Description:Inhibition of rat ROMK by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155927(US9018211, 22 (isomer 2))
Affinity DataIC50:  15nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50505263(CHEMBL4586813)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  18.7nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50:  20nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155929(US9018211, 55)
Affinity DataIC50:  23nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162870(US9056859, 48)
Affinity DataIC50:  35nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50:  36nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162874(US9056859, 122)
Affinity DataIC50:  37nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50249183(CHEMBL4069245)
Affinity DataIC50:  38nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50235196(CHEMBL4064760)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50235198(CHEMBL4066256)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163767(US9062070, 22)
Affinity DataIC50:  40nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50505261(CHEMBL4456474)
Affinity DataIC50:  43nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163826(US9062070, 81 | US9062070, 82)
Affinity DataIC50:  50nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50391781(CHEMBL2146873 | US9073882, 38)
Affinity DataIC50:  55nMAssay Description:Inhibition of rat ROMK channel expressed in HEk293 cells assessed as inhibition of thallium efflux by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50:  56nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162876(US9056859, 217)
Affinity DataIC50:  56nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50:  60nMAssay Description:Inhibition of rat ROMK assessed as thallium flux after 30 mins in presence of ouabain by cell based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50235197(CHEMBL4086237)
Affinity DataIC50:  60nMAssay Description:In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163770(US9062070, 25)
Affinity DataIC50:  60nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163800(US9062070, 55 | US9062070, 56)
Affinity DataIC50:  60nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163826(US9062070, 81 | US9062070, 82)
Affinity DataIC50:  60nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50:  60nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163759(US9062070, 15)
Affinity DataIC50:  60nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50442595(CHEMBL2441408 | US9056859, 12)
Affinity DataIC50:  61nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162873(US9056859, 96)
Affinity DataIC50:  61nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM162869(US9056859, 39)
Affinity DataIC50:  63nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  65nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163777(US9062070, 32)
Affinity DataIC50:  70nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50163355(CHEMBL3793685)
Affinity DataIC50:  70nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50163368(CHEMBL3794427)
Affinity DataIC50:  73nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50163353(CHEMBL3793380)
Affinity DataIC50:  79nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM163766(US9062070, 21)
Affinity DataIC50:  80nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
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