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Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
10 IC50 1 EC50
  • Egl nine homolog 1
  • Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2)
  • Vascular endothelial growth factor A
  • US10562854, No. A41
  • US8536181, A41
  • US9278930, A41
6 IC50 5 EC50
  • Caspase-1
  • Caspase-3
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • (S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
  • 1-[(4-fluorophenyl)methyl]-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
  • CHEMBL372607
  • Pyrrolidine Isatin Analogue 11c
5 Ki 6 EC50
  • HIV WT-A pol protein (wild-type clade A)
  • HIV WT-B pol protein (wild-type clade B)
  • HIV WT-C pol protein (wild-type clade C)
  • HIV-1 isolate WT-control pol protein (CNDO control strain)
  • HIV-1 protease
  • HIV-1 protease M1
  • HIV-1 protease M2
  • HIV-1 protease M3
  • HIV-1 protease M4
  • MDR1
  • MDRC4
  • (2S,3S)-2-(Acetylamino)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)[(2S)-2- methylbutyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-pentanamide (AG-23)
5 Ki 6 EC50
  • HIV WT-A pol protein (wild-type clade A)
  • HIV WT-B pol protein (wild-type clade B)
  • HIV WT-C pol protein (wild-type clade C)
  • HIV-1 isolate WT-control pol protein (CNDO control strain)
  • HIV-1 protease
  • HIV-1 protease M1
  • HIV-1 protease M2
  • HIV-1 protease M3
  • HIV-1 protease M4
  • MDR1
  • MDRC4
  • N-[(1S,2R)-3-[(6-Benzothiazolylsulfonyl)(cyclohexylmethyl)amino]-2-hydroxy-1- (phenylmethyl)propyl]-3-hydroxy-benzamide (AF-72)
5 Ki 6 EC50
  • HIV WT-A pol protein (wild-type clade A)
  • HIV WT-B pol protein (wild-type clade B)
  • HIV WT-C pol protein (wild-type clade C)
  • HIV-1 isolate WT-control pol protein (CNDO control strain)
  • HIV-1 protease
  • HIV-1 protease M1
  • HIV-1 protease M2
  • HIV-1 protease M3
  • HIV-1 protease M4
  • MDR1
  • MDRC4
  • (2S,3S)-2-(Acetylamino)-N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2- methylpropyl)amino]-1-(phenylmethyl)propyl]-3-methyl-pentanamide (AF-68)
5 Ki 6 EC50
  • HIV WT-A pol protein (wild-type clade A)
  • HIV WT-B pol protein (wild-type clade B)
  • HIV WT-C pol protein (wild-type clade C)
  • HIV-1 isolate WT-control pol protein (CNDO control strain)
  • HIV-1 protease
  • HIV-1 protease M1
  • HIV-1 protease M2
  • HIV-1 protease M3
  • HIV-1 protease M4
  • MDR1
  • MDRC4
  • N-[(1S,2R)-3-[(Cyclohexylmethyl)[(4-methoxyphenyl)sulfonyl]amino]-2-hydroxy-1- (phenylmethyl)propyl]-3-hydroxy-benzamide (AF-77)
11 IC50
  • 11-beta-hydroxysteroid dehydrogenase
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • US8575157, 37
8 IC50 3 EC50
  • Egl nine homolog 1
  • Prolyl hydroxylase EGLN3
  • Vascular endothelial growth factor A
  • US8598210, Table XV, 1
  • US8722895, 1: {[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2- carbonyl]-amino}-acetic acid methyl ester
  • US9598370, Example 00126
  • USRE47437, Example {[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester
8 IC50 3 EC50
  • Egl nine homolog 1
  • Prolyl hydroxylase EGLN3
  • Vascular endothelial growth factor A
  • US8598210, Table XV, 6
  • US8722895, 6: [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2- carbonyl)-amino]-acetic acid methyl ester
  • US9598370, Example 00131
  • USRE47437, Example [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2-carbonyl)-amino]-acetic acid methyl ester
8 IC50 3 EC50
  • Egl nine homolog 1
  • Prolyl hydroxylase EGLN3
  • Vascular endothelial growth factor A
  • US8598210, Table XV, 7
  • US8722895, 7: {[5-(2-Chloro-phenyl)-3-hydroxy-pyridine- 2-carbonyl]-amino}-acetic acid methyl ester
  • US9598370, Example 00132
  • USRE47437, Example {[5-(2-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester
8 IC50 3 EC50
  • Egl nine homolog 1
  • Prolyl hydroxylase EGLN3
  • Vascular endothelial growth factor A
  • US8598210, Table XV, 17
  • US8722895, 17: 5-(3-Chlorophenyl)-N-(2-methylamino-2- oxoethyl)-3-hydroxypyridin-2-yl amide
  • US9598370, Example 00142
  • USRE47437, Example 5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxypyridin-2-yl amide
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 5
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 8
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Plasma kallikrein
  • Plasminogen
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 10
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 11
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 13
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 14
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 16
11 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, Table 6, 2
10 IC50 1 Kd
  • Apoptosis regulator Bcl-2
  • BCL-W
  • Bcl-2-like protein 1
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • Isoform Bcl-X(L)
  • 6-(8-(2-(Benzothiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)picolinic acid (Compound 3)
  • CHEMBL2398173
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Hydroxamate 8
  • N-Pentafluorophenylsulfonyl-glycine hydroxamate
  • N-hydroxy-2-[(2,3,4,5,6-pentafluorobenzene)sulfonamido]acetamide
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido]-N-hydroxyacetamide
  • Hydroxamate 10
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido]-N-hydroxyacetamide
  • Hydroxamate 11
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Hydroxamate 14
  • N-hydroxy-2-[(2,3,4,5,6-pentafluorobenzene)sulfonamido]propanamide
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido]-N-hydroxypropanamide
  • Hydroxamate 16
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido]-N-hydroxypropanamide
  • Hydroxamate 17
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Hydroxamate 20
  • N-hydroxy-3-methyl-2-[(2,3,4,5,6-pentafluorobenzene)sulfonamido]butanamide
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido]-N-hydroxy-3-methylbutanamide
  • Hydroxamate 23
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido]-N-hydroxy-3-methylbutanamide
  • Hydroxamate 22
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Hydroxamate 26
  • N-hydroxy-4-methyl-2-[(2,3,4,5,6-pentafluorobenzene)sulfonamido]pentanamide
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido]-N-hydroxy-4-methylpentanamide
  • Hydroxamate 28
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido]-N-hydroxy-4-methylpentanamide
  • Hydroxamate 29
10 Ki 1 IC50
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-4-methylpentanamide
  • Hydroxamate 30
11 Ki
  • Astrosclerin-3
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • 4-Amino-3,5-diiodobenzenesulfonamide
  • 4-amino-3,5-diiodobenzene-1-sulfonamide
  • halogenosulfanilamide deriv. 14
11 IC50
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • US8653092, 63
1 Ki 10 IC50
  • Egl nine homolog 1
  • Egl nine homolog 2
  • Hypoxia-inducible factor 1 (FIH)
  • Prolyl 3-hydroxylase OGFOD1
  • Prolyl 4-hydroxylase
  • Prolyl hydroxylase EGLN3
  • US8653111, 72
6 Ki 5 IC50
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • CHEMBL234350
  • N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-1-(2-phenylethyl)piperidine-4-carboxamide Hydrochloride
  • N-hydroxy-4-{[(4-phenoxybenzene)sulfonyl]methyl}-1-(2-phenylethyl)piperidine-4-carboxamide hydrochloride
  • beta-sulfone 7d
11 IC50
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • US8685992, 14
11 IC50
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • US8685992, 28
11 IC50
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • US8685992, 37
3 Ki 8 IC50
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • (R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonic Acid
  • CHEMBL202932
  • [(1R)-1-{[4-(4-methoxyphenyl)benzene]sulfonamido}-2-methylpropyl]phosphonic acid
  • alpha-arylsulfonylamino phosphonate 1R
1 Ki 10 IC50
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Stromelysin-1
  • (2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-methylbutanoic acid
  • CHEMBL42420
  • alpha-arylsulfonylamino carboxylate 2R
11 IC50
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • Fibroblast activation protein alpha
  • (2S)-1-[(2S)-2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-4-oxobutanoyl]pyrrolidine-2-carbonitrile
  • CHEMBL362018
  • cyanopyrrolidine derivative 6
11 IC50
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • US8748458, 4
3 Ki 6 IC50
0 ΔG°
  • Farnesyl Diphosphate Synthase (FPPS)
  • Farnesyl diphosphate synthase
  • Geranylgeranyl Diphosphate Synthase (GGPPS)
  • Inositol-1(or 4)-monophosphatase 1
  • (1-hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acid
  • Bisphosphonate 4
  • CHEMBL56556
11 Ki
  • Alpha-2A adrenergic receptor
  • Phenylethanolamine N-methyltransferase
  • 7-sulfonamide-THIQ 14
  • CHEMBL290890
  • N-(4-chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
11 IC50
  • BDNF/NT-3 growth factors receptor
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Mitogen-activated protein kinase kinase kinase 5
  • NT-3 growth factor receptor
  • Proto-oncogene tyrosine-protein kinase ROS
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Receptor tyrosine-protein kinase erbB-2
  • Serine/threonine-protein kinase receptor R3
  • US10683289, Example Staurosporine
  • US8822500, Stauro- sporine
  • US9920060, Staurosporine
11 IC50
  • Protein Farnesyltransferase (PFT)
  • Protein Farnesyltransferase (PFT) Chain B
  • Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit
  • Protein farnesyltransferase
  • (2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpropanamido]-3-methylbutanamido]-3-phenylpropanamido]-4-(methylsulfanyl)butanoic acid
  • CHEMBL289302
  • CHEMBL553980
  • CVFM
11 IC50
  • Beta amyloid A4 protein
  • Beta-Secretase (AA 1-460)
  • Beta-secretase 1
  • Beta-secretase 1 (aa 1-460)
  • US10231967, Example 20h
  • US8865911, 20h
  • US8865911, 20h Isomer 1
  • US8865911, 20h Isomer 2
  • US9918985, Example 20h Isomer 1
11 IC50
  • Beta amyloid A4 protein
  • Beta-Secretase (AA 1-460)
  • Beta-secretase 1
  • Beta-secretase 1 (aa 1-460)
  • US10231967, Example 118
  • US8865911, 75
  • US8865911, 76 Isomer 1
  • US8865911, 76 Isomer 2
  • US9918985, Example 118
11 IC50
  • Aurora kinase B
  • Potassium voltage-gated channel subfamily H member 2
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase SYK
  • Tyrosine-protein kinase ZAP-70
  • Vascular endothelial growth factor receptor 2
  • US8871778, 141
11 IC50
  • JAK1/TYK2
  • JAK2/JAK1
  • JAK3/JAK1
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US8895544, 4
11 IC50
  • Rho-kinase (ROCK II)
  • cAMP-Dependent Protein Kinase (PKA)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (E127D)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (L49I)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (L49I/Q181K/T183A)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (L49I/V123M/E127D/Q181K/T183A)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (L49I/V123M/Q181K/T183A)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (Q181K/T183A)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (T183A)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (V123M)
  • cAMP-Dependent Protein Kinase (PKA) Mutant (V123M/Q181K/T183A)
  • KT5720
  • hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate
11 Ki
  • Adrenergic receptor alpha-2
  • Alpha-2A adrenergic receptor
  • Phenylethanolamine N-methyltransferase
  • 8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
  • CHEMBL38681
  • LY134046
  • tetrahydrobenzazepine (THBA) deriv.
11 IC50
  • Androgen Receptor
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Estrogen receptor
  • Glucocorticoid receptor
  • Mineralocorticoid receptor
  • Progesterone receptor
  • US8916600, 6
  • US9738632, Example 6
11 IC50
  • Androgen Receptor
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Estrogen receptor
  • Glucocorticoid receptor
  • Mineralocorticoid receptor
  • Progesterone receptor
  • US8916600, 12
  • US9738632, Example 12
11 IC50
  • Androgen Receptor
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Estrogen receptor
  • Glucocorticoid receptor
  • Mineralocorticoid receptor
  • Progesterone receptor
  • US8916600, 13
  • US9738632, Example 13
11 Ki
  • Coagulation factor X
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator
  • 3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-methylbenzamide
  • APC-10484
  • CHEMBL61327
11 Ki
  • Coagulation factor X
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator
  • APC-10605
  • CHEMBL64097
  • N-(4-carbamimidoylphenyl)-2-hydroxy-3-iodo-5-methylbenzamide
11 Ki
  • Coagulation factor X
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator
  • APC-11922
  • CHEMBL293260
  • N-(4-carbamimidoyl-3-fluorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide
11 Ki
  • Coagulation factor X
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator
  • APC-11421
  • CHEMBL62897
  • N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide
  • N-{4-[amino(imino)methyl]-3-chlorophenyl}-2-hydroxy-3-iodo-5-methylbenzamide
11 IC50
  • HIV-1 Reverse Transcriptase
  • HIV-1 Reverse Transcriptase Mutant (K103N)
  • HIV-1 Reverse Transcriptase Mutant (P236L)
  • HIV-1 Reverse Transcriptase Mutant (Y181C)
  • Human immunodeficiency virus type 1 reverse transcriptase
  • Reverse transcriptase
  • 5-methoxyindole-2-carboxylic acid [N -[3-(aminoethyl)pyridin-2-yl]piperazide]
  • BHAP deriv.
  • CHEMBL280527
  • CHEMBL7264
  • N-ethyl-2-{4-[(5-methoxy-1H-indol-2-yl)carbonyl]piperazin-1-yl}pyridin-3-amine
  • U-87201E
  • bis(heteroaryl)piperazine analog
11 IC50
  • 3',5'-cyclic phosphodiesterase
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 10A (PDE10A)
  • Phosphodiesterase 11A
  • Phosphodiesterase 4
  • Phosphodiesterase 6
  • Phosphodiesterase 8
  • US8969376, 1.006
11 IC50
  • Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)
  • Protein Farnesyltransferase (PFT)
  • Protein Farnesyltransferase (PFT) Chain B
  • Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit
  • 1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine
  • 1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}piperidin-1-yl)-2-(pyridin-4-yl)ethan-1-one
  • CHEMBL289404
  • SCH 44342
11 IC50
  • Coagulation factor VII
  • Coagulation factor X
  • Prothrombin
  • (2R)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-(pyridin-3-yl)ethyl]-3-phenyl-2-(phenylmethane)sulfonamidopropanamide
  • CHEMBL78053
  • Ketothiazole inhibitor 1
11 IC50
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Phosphodiesterase 8
  • Phosphodiesterase Type 10 (PDE10A)
  • Phosphodiesterase Type 11 (PDE11A)
  • Phosphodiesterase Type 2 (PDE2A)
  • Phosphodiesterase Type 3 (PDE3B)
  • Phosphodiesterase Type 4 (PDE4B)
  • Phosphodiesterase Type 4 (PDE4D)
  • Phosphodiesterase Type 5 (PDE5A)
  • Phosphodiesterase Type 7 (PDE7B)
  • Phosphodiesterase Type 9 (PDE9A)
  • (R,S)-Mesopram
  • 5-(4-methoxy-3-propoxy-phenyl)-5-methyl-1,3-oxazolidin-2-one
  • 5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one
  • Daxalipram
11 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10875847, Reference Compound A
  • US8962608, 28-117
11 IC50
  • Beta-secretase 1
  • Beta-secretase 2
  • Cathepsin D
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Potassium voltage-gated channel subfamily H member 2
  • US8962616, 1
3 IC50 4 Kd 1 Koff 2 Kon
2 ΔG°
  • 5-hydroxytryptamine receptor 2A
  • Mitogen-activated protein kinase 14
  • 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea
  • 3-(4-chlorophenyl)-1-(2-methyl-5-tert-butyl-pyrazol-3-yl)urea
  • CHEMBL87277
  • Dopamine D2 receptor and serotonin 2a receptor
  • diaryl urea compound 2
  • diaryl urea inhibitor 1
8 Ki 3 IC50
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • DENV2 protease (NS2B-NS3)
  • Prostaglandin G/H synthase (cyclooxygenase)
  • Sodium channel protein type 2 alpha subunit
  • 4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1)
  • BDBM50222606
11 IC50
  • Phosphodiesterase (TcrPDEC)
  • Phosphodiesterase 1
  • Phosphodiesterase 2A
  • Phosphodiesterase 3
  • Phosphodiesterase 3 (PDE3)
  • Phosphodiesterase 4
  • Phosphodiesterase Type 3 (PDE3A)
  • Phosphodiesterase Type 3 (PDE3B)
  • cGMP-inhibited 3',5'-cyclic phosphodiesterase B
  • cGMP-specific 3',5'-cyclic phosphodiesterase
  • CHEMBL34431
  • Cilostamide
  • N-Cyclohexyl-N-methyl-4-(2-oxo-1,2-dihydro-quinolin-6-yloxy)-butyramide
  • N-cyclohexyl-N-methyl-4-[(2-oxo-1,2-dihydroquinolin-6-yl)oxy]butanamide
11 IC50
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
  • Tumor suppressor p53-binding protein 1
  • N-(3-(Tert-butylamino)propyl)-3-iodobenzamide (19)
11 IC50
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
  • Tumor suppressor p53-binding protein 1
  • N-(3-(Tert-butylamino)propyl)-3-isopropylbenzamide (20)
11 IC50
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
  • Tumor suppressor p53-binding protein 1
  • N-(3-(Tert-butylamino)propyl)-3-(trifluoromethyl)benzamide (21)
11 IC50
  • 1,3-beta-glucan synthase component GLS2
  • ATP-sensitive inward rectifier potassium channel 1
  • Renal Outer Medullary Potassium (ROMK)
  • US9018211, 2B
11 IC50
  • 1,3-beta-glucan synthase component GLS2
  • ATP-sensitive inward rectifier potassium channel 1
  • Renal Outer Medullary Potassium (ROMK)
  • US9018211, 2C
11 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Adrenergic receptor
  • Alpha-1A adrenergic receptor
  • Complement factor B
  • US10093663, Example 25b
  • US9682968, Example-25a (+)
11 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • US10124003, Ex. Compound 52
  • US10894048, Ex Comp 52
  • US9108973, 52
  • US9108973, 52/56
  • US9108973, 56
11 Ki
  • Coagulation factor VII
  • Coagulation factor X
  • Prothrombin
  • Trypsin-1
  • Tryptase
  • 2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximidamide
  • 2-pyridin-2-yl-1H-benzimidazole-6-carboximidamide
  • APD-4
  • CHEMBL381148
11 Ki
  • Coagulation factor VII
  • Coagulation factor X
  • Prothrombin
  • Trypsin-1
  • Tryptase
  • 2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carboximidamide
  • 2-(pyridin-2-ylmethyl)-1H-benzimidazole-6-carboximidamide
  • APD-5
  • CHEMBL204126
11 IC50
  • Tyrosine-protein kinase BTK
  • US10604504, Example 102
  • US9688629, 155
  • US9688629, 156
  • US9802915, Example 156
  • US9920031, Example 156
11 IC50
  • Tyrosine-protein kinase BTK
  • US10604504, Example 158
  • US9688629, 157
  • US9688629, 158
  • US9802915, Example 158
  • US9920031, Example 158
9 Ki 2 IC50
  • Carbonic Anhydrase IV
  • Carbonic Anhydrase VA
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • Intestinal alkaline phosphatase (IAP)
  • Tissue non-specific alkaline phosphatase (TNAP)
  • 4-Benzoylamino-benzenesulfonamide
  • CHEMBL23559
  • N-(4-sulfamoylphenyl)benzamide
  • aromatic sulfonamide compound 17
11 Ki
  • Carbonic Anhydrase (mtCA 1)
  • Carbonic Anhydrase IV
  • Carbonic Anhydrase VA
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)
  • 1-phenyl-3-(4-sulfamoylphenyl)urea
  • aromatic sulfonamide compound 19
4 Ki 4 IC50 3 EC50
  • Kappa-type opioid receptor
  • US10865186, Compound 4
  • US9688638, 4
  • US9688638, 5
  • US9688638, 6
11 IC50
  • MAP kinase-interacting serine/threonine-protein kinase 1
  • MAP kinase-interacting serine/threonine-protein kinase 1/2
  • MAP kinase-interacting serine/threonine-protein kinase 2
  • US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-8-carbonitrile (Cpd. No. 181)
  • US9669031, 47 8-chloro-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 47)
  • US9669031, 71 8-ethyl-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 71)
  • US9669031, 79 3,3-dimethyl-6-(pyrimidin-4-ylamino)-8-vinyl-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 79)
11 Ki
  • Coagulation factor X
  • Prothrombin
  • Trypsin
  • Trypsin-1
  • 2-(5-carbamimidoyl-2-hydroxyphenoxy)-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic acid
  • CHEMBL315014
  • Pyridine template, IV
  • ZK-806688
7 Ki 4 IC50
  • Coagulation factor X
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Vitamin K-dependent protein C
  • (E)-2-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]ethene-1-sulfonamide
  • CHEMBL220050
  • N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1f
5 Ki 1 IC50 5 EC50
  • GRM7
  • Glutamate Carboxypeptidase II (GCPII)
  • Metabotropic glutamate receptor 4 (mGlu4)
  • Metabotropic glutamate receptor 4 (mGluR4)
  • Metabotropic glutamate receptor 6
  • Metabotropic glutamate receptor 6 (mGlu6)
  • Metabotropic glutamate receptor 7 (mGlu7)
  • Metabotropic glutamate receptor 8 (mGlu8)
  • (2S)-2-amino-3-(phosphonooxy)propanoic acid
  • CHEMBL284377
  • L-SOP
  • L-serine O-phosphate
1 Ki 10 IC50
  • Angiopoietin-1 receptor
  • Fibroblast growth factor receptor 1
  • Insulin-like growth factor I receptor
  • Macrophage colony-stimulating factor 1 receptor (CSF1R)
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 8
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine-protein kinase Lck
  • Vascular endothelial growth factor receptor 2
  • 2-aminobenzoxazole, 22
  • 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide
4 Ki 7 IC50
  • Dihydrofolate Reductase (DHFR)
  • Dihydrofolate reductase
  • 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine
  • AR-100
  • Iclaprim
11 IC50
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 9
  • US9133171, 11
  • US9133171, 12
  • US9133171, 2
11 IC50
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 9
  • US9133171, 10
  • US9133171, 15
  • US9133171, 16
11 IC50
  • Dihydrofolate Reductase (DHFR)
  • Dihydrofolate reductase
  • Dihydrofolate reductase (DHFR)
  • 6-[(2,5-dimethoxyphenyl)sulfanyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
  • CHEMBL331986
  • Pyrrolo[2, 3-d]pyrimidine analogue, 1i
11 IC50
  • Dihydrofolate Reductase (DHFR)
  • Dihydrofolate reductase
  • Dihydrofolate reductase (DHFR)
  • 6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-ylmethyl}pteridine-2,4-diamine
  • CHEMBL301769
  • Pteridine compound, 17
11 IC50
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase TYK2
  • US10875847, Compound Oclacitinib
  • US9161939, 1a
  • US9271981, 1a
11 Ki
  • Dihydrofolate reductase
  • Thymidylate Synthase (TS)
  • Thymidylate synthase
  • Thymidylate synthase (TS)
  • 1,8-naphthalein derivative, 17
  • 4,4-bis(3-fluoro-4-hydroxyphenyl)-3-oxatricyclo[7.3.1.0^{5,13}]trideca-1(12),5,7,9(13),10-pentaen-2-one
  • CHEMBL303171
  • Phenolnaphthalein derivative, 1
6 Ki 5 IC50
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS)
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant KICB1
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant V1/S
  • Dihydrofolate reductase
  • 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine
  • CHEMBL129788
  • WR99210
8 IC50 2 Kd 1 EC50
  • Alpha-1A adrenergic receptor
  • Bromodomain-containing protein 4
  • CREB-binding protein
  • CREB-binding protein/Histone acetyltransferase p300
  • PF-CBP1
5 IC50 1 Kd 4 EC50
0 ΔG°
  • Aurora kinase B
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Multidrug resistance-associated protein 4
  • Nuclear receptor subfamily 1 group I member 2
  • Serine/threonine-protein kinase Aurora-B
  • Sodium channel protein type I I alpha subunit
  • 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Felodipine
9 IC50 2 Kd
  • Lysine-specific demethylase 4C
  • Lysine-specific demethylase 5A
  • Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag)
  • Lysine-specific demethylase 5A (KDM5A(aa 1-588)ΔAP)
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5B (KDM5B(aa 1-604)ΔAP)
  • Lysine-specific demethylase 5B (KDM5B(aa 1-755)ΔAP)
  • Lysine-specific demethylase 5C
  • Lysine-specific demethylase 5C (KDM5C(aa 1-789)ΔAP)
  • Lysine-specific demethylase 5D (KDM5D(aa 1-760)ΔAP)
  • 8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol (N10)
9 IC50 1 EC50 0 Other
  • Amine oxidase [flavin-containing] B
  • Angiotensin II receptor
  • Apelin receptor
  • MSRA protein
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
  • 3-phenyl-5H-indeno[1,2-c]pyridazin-5-one
  • Aza-heterocyclic Derivative, 1b
  • CHEMBL421088
  • cid_379337
11 IC50
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • US9186318, 13
1 Ki 3 IC50 7 EC50
  • Androgen Receptor
  • Glucocorticoid
  • Glucocorticoid receptor
  • (1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-1-(thiophen-3-yl)ethan-1-ol
  • CHEMBL310570
  • N-Arylpyrazolo[3,2-c]-Based Ligand, 25
11 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Serine/threonine-protein kinase PIM
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • Serine/threonine-protein kinase pim-3
  • US9187486, 37
  • US9187486, 39
  • US9187486, 60
11 IC50
  • Cathepsin B
  • Cathepsin G
  • Cathepsin K
  • Cathepsin S
  • Dipeptidyl peptidase I
  • Myeloblastin
  • Neutrophil elastase
  • Procathepsin L
  • (2S)-N-[(3S,5E)-6-(benzenesulfonyl)-4-oxo-1-phenylhex-5-en-3-yl]-4-methyl-2-(morpholin-4-ylcarbonylamino)pentanamide
  • CHEMBL222649
  • LHVS
  • Morpholinurea-Leu-Hph-Vinyl-Sulfone-Phenyl
  • Morpholinurea-Leucine-Homophenylalaninevinyl Phenyl Sulfone
11 IC50
  • Histone lysine demethylase PHF8
  • Lysine-specific demethylase 2B
  • Lysine-specific demethylase 3B (KDM3B)
  • Lysine-specific demethylase 4C (KDM4C)
  • Lysine-specific demethylase 5A
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5C
  • Lysine-specific demethylase 6A (KDM6A)
  • CPI-4203
6 Ki 5 IC50
  • Cathepsin B
  • Cathepsin K
  • Cathepsin L2
  • Cathepsin S
  • Procathepsin L
  • (2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4S,7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide
  • Azepan-3-one compound 10
  • CHEMBL203665
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 3
  • US9556187, Example 3
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 4
  • US9556187, Example 4
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 12
  • US9556187, Example 12
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 21
  • US9556187, Example 21
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 24
  • US9556187, Example 24
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 32
  • US9556187, Example 32
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 37
  • US9556187, Example 37
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 38
  • US9556187, Example 38
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 40
  • US9556187, Example 40
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 41
  • US9556187, Example 41
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 66
  • US9556187, Example 66
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 69
  • US9556187, Example 70
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 72
  • US9556187, Example 72
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 77
  • US9556187, Example 77
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 82
  • US9556187, Example 82
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 100
  • US9556187, Example 100
11 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 101
  • US9556187, Example 101
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