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Compounds Sorted by Binding Data per Compound

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22   23   24   25   26   27   28   29   30   31   32   33   34   35   36   37   38   39   40   41   42   
43   44   45   46   47   48   49   50   51   52   53   54   55   56   57   58   59   60   61   62   63   
64   65   66   67   68   69   70   71   72   73   74   75   76   77   78   79   80   81   82   83   84   
85   86   87   88   89   90   91   92   93   94   95   96   97   98   99   100   101   102   103   104   105   
106   107   108   109   110   111   112   113   114   115   116   117   118   119   120   121   122   123   124   125   127   
128   129   130   132   133   134   135   136   137   138   139   140   141   143   144   145   146   147   148   149   150   
151   153   154   155   156   159   160   161   163   164   165   168   170   171   173   174   176   178   179   183   184   
186   188   189   190   191   192   193   196   198   199   200   203   205   206   207   208   209   210   216   220   224   
226   227   230   232   237   238   241   243   248   252   253   259   261   270   274   276   277   285   291   303   304   
313   318   323   325   328   333   335   337   339   341   353   360   361   365   389   393   398   401   413   433   442   
444   445   446   447   448   451   453   454   455   457   458   460   463   465   467   473   477   478   482   484   499   
504   505   506   517   525   543   549   551   554   591   606   663   691   708   796   804   821   825   833   842   847   
854   855   861   873   879   883   887   913   914   925   926   938   947   1010   1027   1050   1052   1081   1082   1102   1115   
1130   1133   1206   1262   1543   1639   1903   2029   
Compounds Sorted Alphabetically
Compound Name
(alphabetical)
Enz. Inhib. DataITC DataBinding TargetsAlternate Compound Names
KiIC50KdEC50KoffKonOther
BDBM10330
PNG
111000000
  • Caspase-1
  • Caspase-3
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • (S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
  • 1-[(4-methoxyphenyl)methyl]-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
  • CHEMBL200677
  • Pyrrolidine Isatin Analogue 11b
BDBM10334
PNG
111000000
  • Caspase-1
  • Caspase-3
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • (S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
  • 1-[(4-hydroxyphenyl)methyl]-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
  • CHEMBL200927
  • Pyrrolidine Isatin Analogue 11f
BDBM10355
PNG
48000000
  • Caspase-1
  • Caspase-3
  • hIL-1beta
  • (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid
  • Ac-YVAD-CHO
  • CHEMBL37630
BDBM103796
PNG
90030000
  • Beta-2 adrenergic receptor
  • Muscarinic acetylcholine receptor M3
  • US8551978, 322
  • US8551978, 323
  • US8816088, I-66
  • US8816088, I-67
  • US9394275, I-66
  • US9572802, Compound I-67
  • US9682957, I-67
BDBM104213
PNG
012000000
  • Serine/threonine-protein kinase PIM-3
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • US8575145, 120
  • US8575145, 121
  • US8575145, 150
  • US8575145, 151
  • US8575145, 90
  • US8575145, 91
BDBM10458
PNG
46110000
  • Acetylcholinesterase
  • Carboxylic ester hydrolase
  • Choline transporter
  • Plasminogen
  • Potassium voltage-gated channel subfamily H member 2
  • Prothrombin
  • Pteridine reductase 1
  • Trypsin
  • Twik-RElated Potassium (K+) channel 1 (TREK1)
  • Voltage-gated potassium channel
  • Voltage-gated potassium channel subfamily A member 1/beta-1
  • 4-AP
  • 4-Aminopyridine 10
  • CHEMBL284348
  • DALFAMPRIDINE
  • pyridin-4-amine
BDBM106722
PNG
012000000
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Sodium-dependent noradrenaline transporter
  • CHEMBL2036264
  • US8586620, 114
BDBM106896
PNG
93000000
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • Serine/threonine-protein kinase pim-3
  • US8592455, 96
BDBM106950
PNG
012000000
  • CDK2/CycE
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Cyclin-Dependent Kinase 7 (CDK7)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 4/G1/S-specific cyclin-E1
  • Cyclin-dependent kinase 9
  • Cyclin-dependent-like kinase 5
  • US8592581, 1
BDBM107486
PNG
012000000
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
  • US8575157, 200
  • US8592410, Comparator 12
  • US8598163, 70
BDBM10844
PNG
012000000
  • Axin-1/Glycogen synthase kinase-3 beta
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Dual specificty protein kinase CLK1
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  • Glycogen Synthase Kinase-3, beta
  • Mitogen-activated protein kinase kinase kinase 14
  • cAMP-Dependent Protein Kinase (PKA)
  • cGMP-Dependent Protein Kinase
  • 4-(1H-indol-3-yl)pyrimidin-2-amine
  • Meridianin G
BDBM10854
PNG
13800000
  • Chitinase 1
  • Chitinase B
  • Chitinase Mutant (A217G)
  • Chitinase Mutant (D175A)
  • Chitinase Mutant (E322A)
  • Chitinase Mutant (M243A)
  • Chitinase Mutant (R301K)
  • Chitinase Mutant (T138A)
  • Chitinase Mutant (Y245F)
  • Endochitinase B1
  • 4-[(1S,4R,10S,13S,16S,18R)-10-{3-[(acetamidomethanimidoyl)amino]propyl}-18-hydroxy-16-(1H-imidazol-4-ylmethyl)-3,9,12,15,20-pentaoxo-2,8,11,14,17-pentaazatricyclo[15.2.1.0^{4,8}]icosan-13-yl]butanoic acid
  • Argadin
  • CHEMBL445236
BDBM108945
PNG
012000000
  • Activin receptor type-1
  • Activin receptor type-1B
  • Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
  • Activin receptor-like kinase 3 (ALK-3)
  • Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
  • Serine/threonine-protein kinase receptor R3
  • Serine/threonine-protein kinase receptor R3 (ALK1)
  • TGF-beta receptor type-1
  • US10017516, Compound 48
  • US9682983, 48
BDBM11140
PNG
012000000
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • (1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropan-2-aminium; 2,2,2-trifluoroacetate
  • beta-dimethylamide 4
  • beta-substituted phenylalanine deriv. 22
  • phenylalanine derived inhibitor, 3
BDBM11189
PNG
012000000
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • (2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium; 2,2,2-trifluoroacetate
  • 3-(S)-fluoropyrrolidide 25
  • beta-substituted phenylalanine deriv. 14
  • phenylalanine derived inhibitor, 4
BDBM11343
PNG
102000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase 12
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • (2S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-3-methylbutanamide
  • Hydroxamate 24
  • N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate
BDBM11362
PNG
111000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido}-N-hydroxypropanamide
  • Hydroxamate 43
  • hydroxamate deriv. B4
BDBM11363
PNG
111000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorobenzene)sulfonamido}-N-hydroxypropanamide
  • Hydroxamate 44
  • hydroxamate deriv. B21
BDBM11364
PNG
111000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • 2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfonamido}-N-hydroxypropanamide
  • Hydroxamate 45
  • hydroxamate deriv. B24
BDBM11719
PNG
012000000
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • Fibroblast Activation Protein (FAP)
  • Fibroblast activation protein alpha
  • (2S)-1-(2-{[4-(2,3-dihydro-1H-isoindol-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile
  • (2S)-Cyanopyrrolidine analogue 21d
  • (2S)-cyanopyrrolidine 4
  • 2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole
BDBM118134
PNG
012000000
  • Activin receptor type-1
  • Activin receptor type-1B
  • Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
  • Activin receptor-like kinase 3 (ALK-3)
  • Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
  • Serine/threonine-protein kinase receptor R3
  • Serine/threonine-protein kinase receptor R3 (ALK1)
  • TGF-beta receptor type-1
  • US10017516, Compound 3
  • US9682983, 3
BDBM118138
PNG
012000000
  • Activin receptor type-1
  • Activin receptor type-1B
  • Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
  • Activin receptor-like kinase 3 (ALK-3)
  • Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
  • Serine/threonine-protein kinase receptor R3
  • Serine/threonine-protein kinase receptor R3 (ALK1)
  • TGF-beta receptor type-1
  • US10017516, Compound 4
  • US9682983, 4
BDBM11870
PNG
57000000
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • 4-{[4-(4-Chlorophenoxy)phenyl]sulfonyl}-N-hydroxy tetrahydro-2H-pyran-4-carboxamide
  • 4-{[4-(4-chlorophenoxy)benzene]sulfonyl}-N-hydroxyoxane-4-carboxamide
  • alpha-sulfone 21
BDBM119440
PNG
111000000
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • Prostaglandin E2 receptor EP2 subtype
  • BDBM119696
  • US8685986, 15
BDBM123325
PNG
44400000
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Orexin receptor type 1
  • Orexin receptor type 2
  • Potassium voltage-gated channel subfamily H member 2
  • US8742106, 1.4
BDBM12355
PNG
39000000
  • Cytochrome P450 2A6
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • 3-(thiophen-3-yl)pyridine
  • CHEMBL361153
  • US8609708,11
  • nicotine 3-heteroaromatic analogue 8
BDBM127644
PNG
012000000
  • High affinity nerve growth factor receptor
  • JAK2 (aa 808-1132)
  • Tyrosine-protein kinase JAK2
  • US10251889, Example 17
  • US10758542, Example 17
  • US8791123, 17
  • US9782415, Example 17
  • US9796724, Example 17
BDBM127808
PNG
012000000
  • High affinity nerve growth factor receptor
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US8791123, 181
  • US9782415, Example 181
BDBM127883
PNG
012000000
  • Activin receptor type-1
  • Activin receptor type-1B
  • Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
  • Activin receptor-like kinase 3 (ALK-3)
  • Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
  • Serine/threonine-protein kinase receptor R3
  • Serine/threonine-protein kinase receptor R3 (ALK1)
  • TGF-beta receptor type-1
  • US10017516, Compound 6
  • US9682983, 6
BDBM135812
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 30
  • US10568888, Example 30
  • US8853226, 30
  • US9393245, 30
  • US9833457, 30
BDBM135813
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 32
  • US10568888, Example 32
  • US8853226, 32
  • US9393245, 32
  • US9833457, 32
BDBM135814
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 33
  • US10568888, Example 33
  • US8853226, 33
  • US9393245, 33
  • US9833457, 33
BDBM135815
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 51
  • US10568888, Example 51
  • US8853226, 51
  • US9393245, 51
  • US9833457, 51
BDBM135816
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 54
  • US10568888, Example 54
  • US8853226, 54
  • US9393245, 54
  • US9833457, 54
BDBM135817
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 84
  • US10568888, Example 84
  • US8853226, 84
  • US9393245, 84
  • US9833457, 84
BDBM135818
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 92
  • US10568888, Example 92
  • US8853226, 92
  • US9393245, 92
  • US9833457, 92
BDBM135820
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 115
  • US10568888, Example 115
  • US8853226, 115
  • US9393245, 115
  • US9833457, 115
BDBM135821
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 118
  • US10568888, Example 118
  • US8853226, 118
  • US9393245, 118
  • US9833457, 118
BDBM135824
PNG
012000000
  • 3',5'-cyclic phosphodiesterase
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • Tumor necrosis factor
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • phosphodiesterase 4B2
  • phosphodiesterase 4D
  • US10085990, Example 127
  • US10568888, Example 127
  • US8853226, 127
  • US9393245, 127
  • US9833457, 127
BDBM136570
PNG
012000000
  • Beta-secretase 1
  • Cathepsin D
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Potassium voltage-gated channel subfamily H member 2
  • US8865706, 9
BDBM139295
PNG
012000000
  • Cereblon/Histone deacetylase 1
  • Cereblon/Histone deacetylase 2
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
  • US10858323, Compound 1
  • US8614223, 73
BDBM13940
PNG
1200000
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