Compound Name
(alphabetical) | Enz. Inhib. Data | ITC Data | Binding Targets | Alternate Compound Names |
|---|
| Ki | IC50 | Kd | EC50 | Koff | Kon | Other |
|---|
BDBM100348
 | 0 | 2 | 18 | 0 | 0 | 0 | 0 | 0 | - Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase SYK
| - US10533001, Example Table 9a.1
- US8501944, 370
- US8501944, 374
- US9868729, Example 38
|
BDBM100351
 | 0 | 2 | 18 | 0 | 0 | 0 | 0 | 0 | - Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase SYK
| - US10533001, Example Table 9a.4
- US8501944, 373
- US8501944, 376
- US9868729, Example 254
|
BDBM108098
 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - Coagulation factor X
- Coagulation factor XI
- Coagulation factor XII
- Complement C1r
- Complement C1r subcomponent
- Complement C1s
- Factor XIIa
- Plasma kallikrein
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Transcription initiation factor IIA
- Vitamin K-dependent protein C
| |
BDBM108110
 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - Coagulation factor X
- Coagulation factor XI
- Coagulation factor XII
- Complement C1r
- Complement C1s
- Factor XIIa
- Plasma kallikrein
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Transcription initiation factor IIA
- Vitamin K-dependent protein C
| |
BDBM10838
 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | - 3-phosphoinositide dependent protein kinase-1
- 5-hydroxytryptamine receptor 1A
- 5-hydroxytryptamine receptor 1D
- 5-hydroxytryptamine receptor 2B
- 5-hydroxytryptamine receptor 2C
- 5-hydroxytryptamine receptor 5A
- 5-hydroxytryptamine receptor 7
- Axin-1/Glycogen synthase kinase-3 beta
- CDK2/Cyclin A/Cyclin A1
- Cyclin-Dependent Kinase 1 (CDK1)
- Cyclin-Dependent Kinase 5 (CDK5)
- Cyclin-Dependent Kinase 9 (CDK9)
- Cyclin-dependent kinase 1
- Cyclin-dependent-like kinase 5
- D(1B) dopamine receptor
- Glycogen Synthase Kinase-3, beta
- Muscarinic acetylcholine receptor M5
- Sodium-dependent dopamine transporter
- cAMP-Dependent Protein Kinase (PKA)
- cGMP-Dependent Protein Kinase
| - 3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol
- Meridianin A
|
BDBM111123
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Activin receptor type-1
- Activin receptor type-1B
- Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
- Activin receptor-like kinase 3 (ALK-3)
- Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
- Serine/threonine-protein kinase receptor R3
- Serine/threonine-protein kinase receptor R3 (ALK1)
- TGF-beta receptor type-1
| - US10017516, Compound 2
- US9682983, 2
|
BDBM11328
 | 14 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | - 72 kDa type IV collagenase
- Carbonic Anhydrase IV
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Collagenase (ChC)
- Disintegrin and metalloproteinase domain-containing protein 17
- Interstitial collagenase
- Matrix metalloproteinase-12 (MMP12)
- Matrix metalloproteinase-14 (MMP14)
- Matrix metalloproteinase-7 (MMP7)
- Matrix metalloproteinase-9
- Meprin A subunit beta
- Neutrophil collagenase
- Stromelysin-1
| - CHEMBL83508
- Hydroxamate 9
- N-hydroxy-2-[(4-methoxybenzene)sulfonamido]acetamide
|
BDBM123687
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
- Homo sapiens phosphodiesterase 2A (PDE2A)
- Phosphodiesterase 11A (PDE11A)
- Phosphodiesterase 7B (PDE7B)
- Phosphodiesterase 8
- Phosphodiesterase 9A
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B
- cAMP-specific 3',5'-cyclic phosphodiesterase 7B
- cGMP-inhibited 3',5'-cyclic phosphodiesterase B
- cGMP-specific 3',5'-cyclic phosphodiesterase
| |
BDBM123850
 | 16 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | - 5-hydroxytryptamine receptor 1A
- 5-hydroxytryptamine receptor 2A
- 5-hydroxytryptamine receptor 2C
- D(2) dopamine receptor
- D(3) dopamine receptor
- D(4) dopamine receptor
| - US8748608, 34
- US8748608, 34 Enantiomer A
- US8748608, 34 Enantiomer B
|
BDBM13604
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Leukocyte common antigen
- Protein-Tyrosine Phosphatase 1B (PTP1B)
- Protein-tyrosine phosphatase 1B
- Tyrosine-protein phosphatase non-receptor type 2
| - 6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl]phenyl}-2-(1-methoxy-3-methylbutyl)quinoline-8-phosphonic acid
- Aryldifluoromethyl-Phosphonic Acid Inhibitor 11
- CHEMBL266753
|
BDBM14210
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Aurora kinase A/B
- Aurora kinase A/Targeting protein for Xklp2
- Aurora kinase B
- Aurora kinase B-A
- Cyclin-dependent kinase 1
- Epidermal growth factor receptor
- Serine/threonine-protein kinase Aurora-A
- Serine/threonine-protein kinase PLK1
| - 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)-quinazoline
- CHEMBL202721
- N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide
- ZM447439
|
BDBM160786
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Caspase-1
- Caspase-10
- Caspase-2
- Caspase-3
- Caspase-4
- Caspase-5
- Caspase-6
- Caspase-7
- Caspase-8
- Caspase-9
| - US10167313, Compound 53
- US9045524, 53
|
BDBM163879
 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - Orexin receptor type 1
- Orexin receptor type 2
| - US9062078, 11
- US9062078, 12A
- US9062078, 12B
- US9475819, 11
- US9637496, 12B
- US9695183, 12B
|
BDBM172038
 | 1 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | - EZH1/PRC2
- EZH2(Y641F)
- EZH2/SUZ12/EED/RBBP7/RBBP4
- Histone-lysine N-methyltransferase EZH2
| - US10155002, Compound 44
- US10647700, Compound EPZ6438
- US9090562, 143
- US9090562, 44
- US9394283, 1
|
BDBM173295
 | 8 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | - P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
| - US10323032, Example 33
- US9096596, 33
- US9604982, Example 33
|
BDBM174802
 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | - P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
| - US10053462, 33
- US9102686, 33
- US9540388, 32
|
BDBM1866
 | 1 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | - HIV-1 Reverse Transcriptase
- HIV-1 Reverse Transcriptase Mutant (L100I)
- HIV-1 Reverse Transcriptase Mutant (Y181C)
- Human immunodeficiency virus type 1 reverse transcriptase
- Reverse transcriptase
| - 3-(5-bromopyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]thiourea hydrochloride
- LY-300046 HCl
- LY300046HCl
- N-(2-(2-Pyridylethyl))-N -(2-(5-bromopyridyl))thiourea
- PETT deriv.
- Trovirdine
|
BDBM191597
 | 0 | 18 | 2 | 0 | 0 | 0 | 0 | 0 | - Lysine-specific demethylase 4C
- Lysine-specific demethylase 5A
- Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag)
- Lysine-specific demethylase 5A (KDM5A(aa 1-588)ΔAP)
- Lysine-specific demethylase 5A (KDM5A(aa 1-739)ΔAP(2C-2S))
- Lysine-specific demethylase 5B
- Lysine-specific demethylase 5B (KDM5B(aa 1-604)ΔAP)
- Lysine-specific demethylase 5B (KDM5B(aa 1-755)ΔAP)
- Lysine-specific demethylase 5C
- Lysine-specific demethylase 5C (KDM5C(aa 1-789)ΔAP)
- Lysine-specific demethylase 5D (KDM5D(aa 1-760)ΔAP)
| - 3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluoro-1H-indazol-3-yl)amino)-isonicotinic acid (N11)
- US10040779, Example 73
- US10336727, Example 73
- US9617242, Example 73
|
BDBM191640
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - ALK tyrosine kinase receptor
- Cereblon/Histone deacetylase 6
- Hepatocyte growth factor receptor
- Histone deacetylase 1
- Histone deacetylase 10
- Histone deacetylase 11
- Histone deacetylase 2
- Histone deacetylase 3
- Histone deacetylase 4
- Histone deacetylase 5
- Histone deacetylase 7
- Histone deacetylase 8
- Histone deacetylase 9
- Mast/stem cell growth factor receptor Kit
- Platelet-derived growth factor receptor beta
- Proto-oncogene tyrosine-protein kinase Src
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Tyrosine-protein kinase receptor FLT3
- Tyrosine-protein kinase receptor UFO
- Vascular endothelial growth factor receptor 2
| |
BDBM194087
 | 0 | 12 | 8 | 0 | 0 | 0 | 0 | 0 | - Cytoplasmic tyrosine-protein kinase BMX
- Epidermal growth factor receptor
- Fyn/BTK
- LCK/BTK
- LynA/BTK
- Receptor protein-tyrosine kinase erbB-4
- Receptor tyrosine-protein kinase erbB-2
- Tyrosine-protein kinase BTK
- Tyrosine-protein kinase ITK/TSK
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase TEC
| - US9199997, 9
- US9879013, 19(2)
|
BDBM194645
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - 72 kDa type IV collagenase
- A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
- A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
- Collagenase 3
- Interstitial collagenase
- Matrix metalloproteinase 12
- Matrix metalloproteinase 14
- Matrix metalloproteinase-12 (MMP12)
- Matrix metalloproteinase-14 (MMP14)
- Matrix metalloproteinase-7 (MMP7)
- Matrix metalloproteinase-9
- Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
- Neutrophil collagenase
- Stromelysin-1
| |
BDBM194646
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - 72 kDa type IV collagenase
- A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
- A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
- Collagenase 3
- Interstitial collagenase
- Matrix metalloproteinase 12
- Matrix metalloproteinase 14
- Matrix metalloproteinase-12 (MMP12)
- Matrix metalloproteinase-14 (MMP14)
- Matrix metalloproteinase-7 (MMP7)
- Matrix metalloproteinase-9
- Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
- Neutrophil collagenase
- Stromelysin-1
| |
BDBM19489
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Cathepsin B
- Cathepsin K
- Cathepsin S
- Procathepsin L
| - (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfon
- (2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-[4-(4-methanesulfonylphenyl)phenyl]ethyl]amino}pentanamide
- CHEMBL437501
- L-873724
|
BDBM202703
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 49
- US10709712, Example 49
- US9242969, 49
- US9694016, 49
|
BDBM202742
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 88
- US10709712, Example 88
- US9242969, 88
- US9694016, 1170
|
BDBM202743
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 89
- US10709712, Example 89
- US9242969, 89
- US9694016, 1171
|
BDBM202744
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 90
- US10709712, Example 90
- US9242969, 90
- US9694016, 1172
|
BDBM202745
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 91
- US10709712, Example 91
- US9242969, 91
- US9694016, 1173
|
BDBM202784
 | 0 | 16 | 0 | 4 | 0 | 0 | 0 | 0 | - B-RAF V600E
- BRAF/CRAF
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 131
- US10709712, Example 131
- US9242969, 131
- US9694016, 131
|
BDBM202808
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 155
- US10709712, Example 155
- US9242969, 155
- US9694016, 155
|
BDBM202809
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 156
- US10709712, Example 235
- US9242969, 156
- US9694016, 235
|
BDBM202818
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 165
- US10709712, Example 165
- US9242969, 165
- US9694016, 653
|
BDBM202819
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 651
- US10709712, Example 166
- US9242969, 166
- US9694016, 651
|
BDBM202820
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 645
- US10709712, Example 167
- US9242969, 167
- US9694016, 645
|
BDBM202821
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - B-RAF V600E
- C-RAF
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
| - US10245267, Example 168
- US10709712, Example 168
- US9242969, 168
- US9694016, 658
|
BDBM20557
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Transient receptor potential cation channel subfamily V member 1
- Vanilloid receptor
| - AMG 517
- CHEMBL229430
- JMC503515 Compound 23
- N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
- US8796328, A
- US8802711, H
|
BDBM220140
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Acetyl-CoA carboxylase 1
- Acetyl-CoA carboxylase 2
| |
BDBM223311
 | 1 | 0 | 10 | 0 | 0 | 0 | 0 | 0 | - Ephrin receptor
- Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD)
- Ephrin type-A receptor 4 ligand binding domain (D61G/E62G-EphA4-LBD)
- Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)
- Ephrin type-A receptor 4 ligand binding domain (I159A-EphA4-LBD)
- Ephrin type-A receptor 4 ligand binding domain (I59A-EphA4-LBD)
- Ephrin type-A receptor 4 ligand binding domain (I59G-EphA4-LBD)
- Ephrin type-A receptor 4 ligand binding domain (I67A-EphA4-LBD)
- Ephrin type-A receptor 4 ligand binding domain (M164A-EphA4-LBD)
- Ephrin type-A receptor 4 ligand binding domain (M60A-EphA4-LBD)
| |
BDBM223395
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - 1,3-beta-glucan synthase component GLS2
- Beta-secretase 1
- Beta-secretase 1 (BACE1)
- Beta-secretase 2
- Cathepsin D
- Cytochrome P450 2D6 (2D6)
- Potassium voltage-gated channel subfamily H member 2
| - US9315520, 1
- US9315520, Comparator 1
- US9315520, Example 1
- US9315520, Example 2
- US9605007, Example 1
|
BDBM22496
 | 1 | 0 | 0 | 19 | 0 | 0 | 0 | 0 | - Free fatty acid receptor 1
- Free fatty acid receptor 4
- G-protein coupled receptor 120
| - 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
- CHEMBL207881
- carboxylic acid agonist, 2
|
BDBM230091
 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | - Tyrosine-protein kinase BTK
- Tyrosine-protein kinase JAK2
| - US10106559, Example 14
- US10435415, Example 14
- US9334290, 13
- US9334290, 14
- US9850258, Example 14
|
BDBM23446
 | 2 | 11 | 0 | 1 | 0 | 0 |
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