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Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
9 Ki 9 IC50 6 EC50
  • Caspase-1
  • Caspase-2
  • Caspase-3
  • Caspase-4
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • Caspase-9
  • (S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin
  • 1-benzyl-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
  • CHEMBL439753
  • IST-3
  • Isatin Sulfonamide 34
  • JMC522188 Compound 2
  • Pyrrolidine Isatin Analogue 2
2 IC50 1 Kd
0 ΔG°
  • BirA Bifunctional Protein
  • BirA Bifunctional Protein Mutant (V214A)
  • BirA Bifunctional Protein Mutant (V219A)
  • BirA Bifunctional Protein Mutant (W223A)
  • Streptavadin(N23A)
  • Streptavadin(N23E)
  • Streptavadin(S27A)
  • Streptavadin(W108F)
  • Streptavadin(W120F)
  • Streptavadin(W79F)
  • Streptavadin(Y43A)
  • Streptavidin
  • Streptavidin (Y43F)
  • Tyrosine-protein kinase ABL1
  • 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid
  • Biotin
  • cid_171548
  • cid_253
3 Ki 21 IC50
  • Cytochrome P450 2A6
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • CHEMBL178681
  • CHEMBL359657
  • US8609708, 1
  • US8609708, 31
  • [5-(pyridin-3-yl)thiophen-2-yl]methanamine
  • nicotine 3-heteroaromatic analogue 1a
24 Ki
  • Coagulation factor IX
  • Coagulation factor X
  • Prothrombin
  • Trypsin
  • Trypsin II
  • Trypsin-1
  • 1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide
  • CHEMBL152854
  • CHEMBL37251
  • SN-429
5 Ki 19 IC50
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 1
  • Phosphodiesterase 3
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • cGMP-specific 3',5'-cyclic phosphodiesterase
  • 6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one
  • 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one
  • CI 930
  • CI-930
24 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 2
  • US8969352, 2
  • US9611277, Example 125
  • US9845333, 2
24 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 12
  • US8969352, 12
  • US9611277, Example 12
  • US9845333, 12
5 Ki 19 IC50
  • Dihydroorotate Dehydrogenase (DHODH)
  • Dihydroorotate dehydrogenase
  • Dihydroorotate dehydrogenase (quinone), mitochondrial
  • (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
  • A77 1726
  • CHEMBL973
  • CHEMBL999
  • TERIFLUNOMIDE
24 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 176
  • US9062078, 55
  • US9475819, 55
  • US9637496, 55
  • US9695183, 55
24 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 238
  • US9062078, 297
  • US9475819, 238
  • US9637496, 395
  • US9695183, 238
  • US9695183, 297
8 Ki 14 IC50 2 EC50
  • Cytochrome P450 3A
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10323032, Example 58
  • US9096596, 58
  • US9604982, Example 58
17 Ki 2 IC50 5 EC50
  • GRIA1
  • GRIA2
  • GRIA3
  • GRIK1
  • Glutamate Carboxypeptidase II (GCPII)
  • Glutamate receptor 1
  • Glutamate receptor ionotropic AMPA
  • Glutamate receptor ionotropic, AMPA 2
  • Glutamate receptor ionotropic, AMPA 4
  • Glutamate receptor ionotropic, kainate
  • Glutamate receptor ionotropic, kainate 1
  • Glutamate receptor ionotropic, kainate 2
  • Grik5
  • Ionotropic glutamate receptor kainate 2/5
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 4 (mGluR4)
  • Metabotropic glutamate receptor 6
  • NMDA receptor subunit 2C (GluN2C)
  • (2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid
  • 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid
  • AMPA
  • CHEMBL276815
3 Ki 21 IC50
  • 6His.FMS.538-922(FGFR)
  • Alpha-synuclein
  • Beta amyloid A4 protein
  • Epidermal growth factor receptor
  • Insulin-like growth factor I receptor
  • Luciferin 4-monooxygenase
  • Macrophage colony-stimulating factor 1 receptor (aa 538-972)
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Receptor tyrosine-protein kinase erbB-2
  • Tau
  • Vascular endothelial growth factor receptor 1
  • cFMS -Tie-2 Chimera
  • (3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-dihydro-1H-indol-2-one
  • CHEMBL328710
  • SU 4312
  • SU4312
8 Ki 8 IC50 8 EC50
  • Mu-type opioid receptor
  • US10287250, Compound C.11
  • US10752592, Compound TABLE C.-3
  • US9133125, Table C, Compound 10
  • US9133125, Table C, Compound 11
  • US9656961, Example 00161
24 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • BDBM198340
  • US9216999, 10
  • US9556187, Example 141
24 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 650
  • US10709712, Example 189
  • US9242969, 189
  • US9694016, 650
18 Ki 4 IC50 2 Kd
  • Acyl-protein thioesterase 1
  • Acyl-protein thioesterase 1 (APT1 I75L)
  • Acyl-protein thioesterase 1 (APT1 I75L/S82A)
  • Acyl-protein thioesterase 1 (APT1 I75L/S82A/Q83P)
  • Acyl-protein thioesterase 1 (APT1 I75L/S82A/Q83P/R149H/A150R/S151A)
  • Acyl-protein thioesterase 1 (APT1 L176M)
  • Acyl-protein thioesterase 1 (APT1 Q83P)
  • Acyl-protein thioesterase 2
  • Acyl-protein thioesterase 2 (APT2 H152R)
  • Acyl-protein thioesterase 2 (APT2 L78I)
  • Acyl-protein thioesterase 2 (APT2 L78I/A85S)
  • Acyl-protein thioesterase 2 (APT2 L78I/A85S/P86Q)
  • Acyl-protein thioesterase 2 (APT2 L78I/A85S/P86Q/H152R/R153A/A154S)
  • Acyl-protein thioesterase 2 (APT2 M178L)
  • Acyl-protein thioesterase 2 (APT2 P86Q)
  • Acyl-protein thioesterase 2 (APT2 S122A)
  • Pyridoxal kinase
  • ML349
8 Ki 13 IC50 1 Kd 2 EC50
  • Endoplasmin
  • Heat Shock Protein 90 (Hsp90)
  • Heat shock protein 75 kDa, mitochondrial
  • Heat shock protein 90 beta
  • Heat shock protein HSP 90-alpha
  • Heat shock protein HSP 90-beta
  • Histone deacetylase
  • 2-amino-6-halopurine analogue, 20
  • 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine
  • CHEMBL467399
  • hsp90_107
12 Ki 6 IC50 6 EC50
  • Cannabinoid receptor
  • Delta-type opioid receptor
  • Mu-type opioid receptor
  • Opioid receptors; mu & delta
  • mu/kappa opioid receptor
  • (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamide
  • Enkephalin Amide
  • YDAGF-NH2
24 IC50
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK2
  • US10106559, Example 73
  • US10435415, Example 73
  • US9334290, 49
  • US9334290, 50
  • US9334290, 73
  • US9850258, Example 73
4 Ki 20 IC50
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • HIV-1 Integrase
  • Hepatitis C virus NS5B RNA-dependent RNA polymerase
  • Human immunodeficiency virus type 1 integrase
  • Integrase
  • Reverse transcriptase
  • 4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-dioxobutanoic acid
  • CHEMBL421353
  • CHEMBL50605
  • L-731988
24 IC50
  • Phosphodiesterase 5A
  • US9359371, Avanafil
2 IC50 3 Kd 19 EC50
  • 5'-AMP-activated protein kinase subunit beta-1
  • 5'-AMP-activated protein kinase subunit gamma-1
  • 5'-AMP-activated protein kinase Complex 1
  • 5'-AMP-activated protein kinase catalytic subunit alpha-1/beta-1/gamma-1
  • 5-hydroxytryptamine receptor 2B
  • AMPK alpha1/beta2/gamma1
  • AMPK alpha2/beta1/gamma1
  • AMPK alpha2/beta2/gamma3
  • Phosphodiesterase 3
  • Prkaa1/Prkab2/Prkag1
  • US9394285, 1
24 IC50
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • 3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]propanenitrile
  • US10005788, 2 (2nd peak, cis-)
  • US10053465, 3
  • US10065963, Compound 3
  • US10125150, Example 3
  • US10336759, # 3
  • US10479803, Example 3
  • US10519163, Example 3
  • US10675284, Example 3
  • US9732097, Example 3
5 Ki 19 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 148
  • US10150765, Example 148
  • US10703749, Example 148
  • US9464084, 148
22 Ki 1 IC50 1 EC50
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 5A
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Adrenergic alpha1B
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Gamma-aminobutyric acid receptor subunit alpha-1
  • Histamine H1 receptor
  • US9481688, 1
  • US9481688, 3
24 IC50
  • Beta-chymotrypsin
  • Beta-lactamase AmpC
  • CDK2/Cyclin E/G1/S-specific cyclin E2
  • CaM kinase II
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Malate dehydrogenase
  • Mixed Lineage Kinase 1 (MLK1)
  • Mixed Lineage Kinase 3 (MLK3)
  • Myosin light chain kinase, smooth muscle
  • Protein Kinase C
  • Protein kinase C (PKC)
  • Protein kinase C alpha type
  • Tyrosine-protein kinase JAK3
  • Zinc finger protein GLI1
  • Zinc finger protein GLI2
  • cAMP-Dependent Protein Kinase (PKA)
  • cAMP-dependent protein kinase (PKA)
  • cAMP-dependent protein kinase catalytic subunit gamma
  • cGMP-Dependent Protein Kinase
  • 3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaen-12-one
  • CHEMBL16958
  • K-252c
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimethyl-1H-pyrazol-4-yl)-1-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one
  • US10251892, Example 100
  • US10632126, Example 47
  • US9708318, 100
  • US9708318, 47
24 IC50
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
  • Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A
  • Phosphodiesterase, PDE1/PDE5
  • 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1
  • US10034861, Example 121
  • US10034861, Example 122
  • US10512632, Example 122
  • US10766893, Example S122
  • US10806718, Example 122
24 IC50
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
  • Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A
  • Phosphodiesterase, PDE1/PDE5
  • 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1
  • US10034861, Example 123
  • US10034861, Example 124
  • US10512632, Example 123
  • US10766893, Example S124
  • US10806718, Example 124
24 IC50
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
  • Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A
  • Phosphodiesterase, PDE1/PDE5
  • 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1
  • US10034861, Example 136
  • US10034861, Example 137
  • US10512632, Example 137
  • US10766893, Example S137
  • US10806718, Example 137
24 IC50
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
  • Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A
  • Phosphodiesterase, PDE1/PDE5
  • 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1
  • US10034861, Example 138
  • US10034861, Example 139
  • US10512632, Example 139
  • US10766893, Example S139
  • US10806718, Example 139
24 IC50
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
  • Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A
  • Phosphodiesterase, PDE1/PDE5
  • 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1
  • US10034861, Example 140
  • US10034861, Example 141
  • US10512632, Example 141
  • US10766893, Example S141
  • US10806718, Example 141
24 IC50
  • Cytochrome P450 2D6
  • Glutamate receptor ionotropic, NMDA 2B
  • Melanin-concentrating hormone receptor 2/HERG
  • Potassium voltage-gated channel subfamily H member 2
  • US10030026, Compound LX-1
  • US10221182, Compound LX-1
  • US10294230, Compound LX-1
  • US10420768, Compound LX-1
  • US10584127, Compound LX-1
  • US9968610, Compound LX-1
9 Ki 15 IC50
  • Adenosine deaminase
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 1
  • Phosphodiesterase 11A (PDE11A)
  • Phosphodiesterase 3
  • Phosphodiesterase 8
  • Phosphodiesterase 9A
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • cGMP-specific 3',5'-cyclic phosphodiesterase
  • (+)-EHNA
  • (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
  • CHEMBL296435
24 IC50
  • 3',5'-cyclic phosphodiesterase
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • US10023575, Example 53
  • US10023575, Example 54
  • US10023575, Example 85a
  • US10023575, Example 86a
  • US10023575, Example 86b
  • US10479794, Example 86b
  • US10875867, Example 54
24 IC50
  • 3',5'-cyclic phosphodiesterase
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • US10023575, Example 68
  • US10023575, Example 69
  • US10023575, Example 70
  • US10023575, Example 71
  • US10479794, Example 71
  • US10875867, Example 71
24 IC50
  • 3',5'-cyclic phosphodiesterase
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • US10023575, Example 72
  • US10023575, Example 73
  • US10023575, Example 74
  • US10023575, Example 75
  • US10479794, Example 75
  • US10875867, Example 75
4 Ki 20 IC50
  • Cytoplasmic tyrosine-protein kinase BMX
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Macrophage colony-stimulating factor 1 receptor (CSF1R)
  • Pancreatic endoplasmic reticulum kinase (PERK)
  • Serine/threonine-protein kinase TAO2
  • Tyrosine-protein kinase Blk
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lyn
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 3
  • 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
  • US10294223, Cpd No. 6
  • US9567334, Example 6
  • US9815834, Compound 6
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-{3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridin]-6'-yl]phenyl}acrylamide
  • US10016438, Example 1
  • US9580423, Example 1
  • US9801889, Example 1
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)-4-methylphenyl)acrylamide
  • US10016438, Example 2
  • US9580423, Example 2
  • US9801889, Example 2
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)pyridin-3-yl)acrylamide
  • US10016438, Example 3
  • US9580423, Example 3
  • US9801889, Example 3
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(4-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)pyridin-2-yl)acrylamide
  • US10016438, Example 4
  • US9580423, Example 4
  • US9801889, Example 4
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)-2-fluoro-4-methylphenyl)acrylamide
  • US10016438, Example 6
  • US9580423, Example 6
  • US9801889, Example 6
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)-6-methylpyridin-3-yl)acrylamide
  • US10016438, Example 7
  • US9580423, Example 7
  • US9801889, Example 7
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • 6'-(1-acryloylpiperidin-3-yl)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridin]-3'(2'H)-one
  • US10016438, Example 8
  • US9580423, Example 8
  • US9801889, Example 8
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)phenyl)-N-methylacrylamide
  • US10016438, Example 9
  • US9580423, Example 9
  • US9801889, Example 9
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-{3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridin]-6'-yl]-5-morpholin-4-ylphenyl}acrylamide
  • US10016438, Example 10
  • US9580423, Example 10
  • US9801889, Example 10
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-[3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridin]-6'-yl]-5-(morpholin-4-ylmethyl)phenyl]acrylamide
  • US10016438, Example 11
  • US9580423, Example 11
  • US9801889, Example 11
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)-2-(morpholinomethyl)phenyl)acrylamide
  • US10016438, Example 12
  • US9580423, Example 12
  • US9801889, Example 12
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)-2-(hydroxymethyl)phenyl)acrylamide
  • US10016438, Example 13
  • US9580423, Example 13
  • US9801889, Example 13
24 IC50
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Heat shock protein HSP 90-alpha
  • Lipoamide Dehydrogenase (Lpd)
  • MKP-3
  • Methyl-CpG binding domain protein 2
  • Pyruvate dehydrogenase (PDH)
  • SUMO-activating enzyme
  • tyrosyl-DNA phosphodiesterase 2
  • MLS000054842
  • N-(1-butyl-3-cyano-2-pyrrolo[3,2-b]quinoxalinyl)benzamide
  • N-(1-butyl-3-cyano-pyrrolo[3,2-b]quinoxalin-2-yl)benzamide
  • N-(1-butyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)benzamide
  • SMR000060333
  • US9045483, 3
  • US9073941, 1003
  • cid_1910302
24 IC50
  • Bromodomain-containing protein 4
  • Bromodomain-containing protein 9
  • CECR2 (aa 424-538)
  • CREB-binding protein
  • Cat eye syndrome critical region protein 2
  • Peregrin
  • Transcription initiation factor TFIID subunit 1
  • 3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethyl-benzamide
  • US10183009, Example 8
24 IC50
  • 5-hydroxytryptamine receptor 2A
  • Glycogen synthase kinase-3
  • Mitogen-activated protein kinase 12
  • Mitogen-activated protein kinase 12 Gamma
  • Mitogen-activated protein kinase 14
  • 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
  • US10238658, Example 9
  • US10813932, Example 9
  • US9724347, Example 2
  • US9724347, Example 9
  • US9993478, Example 9
24 IC50
  • 5-hydroxytryptamine receptor 2A
  • Glycogen synthase kinase-3
  • Mitogen-activated protein kinase 12
  • Mitogen-activated protein kinase 12 Gamma
  • Mitogen-activated protein kinase 14
  • 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
  • US10238658, Example 19
  • US10813932, Example 19
  • US9724347, Example 19
  • US9724347, Example 6
  • US9993478, Example 19
17 IC50 7 EC50
  • DNA dC->dU-editing enzyme APOBEC-3G
  • G protein signalling regulator 19
  • Gag-Pol polyprotein
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • MPI protein
  • Mannose-6-phosphate isomerase
  • RGS7
  • Regulator of G-protein signaling 8
  • diphosphomevalonate decarboxylase
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • insulin-degrading enzyme isoform 1 precursor
  • large T antigen
  • mevalonate kinase
  • phosphatase, orphan 1
  • phosphomannomutase 2
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
  • streptokinase A precursor
  • 2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonyl-phenyl)-1,2-benzothiazol-3-one
  • 2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one
  • 2-(2-morpholino-5-morpholinosulfonyl-phenyl)-1,2-benzothiazol-3-one
  • 2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-1,2-benzothiazol-3-one
  • MLS000055722
  • SMR000060745
  • cid_2325815
24 Ki
  • Adrenergic receptor
  • Histamine H2 receptor
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Nitric-oxide synthase, brain
  • Nitric-oxide synthase, endothelial
  • Sodium-dependent serotonin transporter
  • US9783500, Compound 17
17 IC50 7 EC50
  • DNA dC->dU-editing enzyme APOBEC-3G
  • G protein signalling regulator 19
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • M18 aspartyl aminopeptidase
  • MPI protein
  • MSRA protein
  • Mannose-6-phosphate isomerase
  • Procathepsin L
  • RGS7
  • Regulator of G-protein signaling 8
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • glucose-6-phosphate dehydrogenase
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • hexokinase
  • large T antigen
  • neutrophil cytosolic factor 1
  • phosphomannomutase 2
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
  • 6-fluoranyl-2-(2-methylphenyl)-1,2-benzothiazol-3-one
  • 6-fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one
  • 6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one
  • 6-fluoro-2-(o-tolyl)-1,2-benzothiazol-3-one
  • MLS000729299
  • SMR000307577
  • cid_1510379
24 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3′-oxo-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-[2,7]naphthyridin]6′-yl]methyl}acrylamide
  • US10214528, Example 1
  • US10738048, Example 1
  • US9890156, Example 1
13 IC50 11 EC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Nuclear receptor ROR-alpha
  • Nuclear receptor ROR-beta
  • Nuclear receptor ROR-gamma
  • Nuclear receptor ROR-gamma (RORC)
  • Nuclear receptor subfamily 1 group I member 2
  • Oxysterols receptor LXR-alpha
  • Oxysterols receptor LXR-beta
  • US10273259, Example 69
  • US10711020, Example 69
24 EC50
  • Axin-1/Glycogen synthase kinase-3 beta
  • Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  • Proto-oncogene Wnt-1
  • US10287267, Compound 1014
  • US10287267, Compound 118
  • US10287267, Compound 965
  • US10508099, Compound 1014
  • US10556885, Compound 1014
18 IC50 6 EC50
  • Alkaline phosphatase placental-like
  • Alkaline phosphatase, tissue-nonspecific isozyme
  • Alpi
  • DNA dC->dU-editing enzyme APOBEC-3G
  • Eph receptor A4
  • Estradiol receptor beta (ERβ)
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • Intestinal alkaline phosphatase
  • M18 aspartyl aminopeptidase
  • POsterior Segregation family member (pos-1)
  • Procathepsin L
  • RecName: Full=Zinc finger protein mex-5
  • TCRAV4S1
  • Trypanosoma brucei RNA editing ligase 1
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • lens epithelium-derived growth factor p75
  • nuclear receptor subfamily 4, group A, member 1
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • serum albumin precursor
  • 4-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)-1,2-benzenediol
  • 4-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)benzene-1,2-diol
  • 4-(2,3-dihydroimidazo[2,1-b]thiazol-6-yl)benzene-1,2-diol
  • 4-(2,3-dihydroimidazo[2,1-b]thiazol-6-yl)pyrocatechol
  • MLS000530540
  • SMR000135520
  • cid_877570
24 IC50
  • ALK tyrosine kinase receptor
  • ALK tyrosine kinase receptor (L1196M)
  • US10543199, Compound 45
  • US10543199, Compound 58
  • US10543199, Compound 72
  • US10543199, Compound 76
  • US10543199, Compound 83
  • US10780082, Compound 83
24 IC50
  • Toll-like receptor 7
  • Toll-like receptor 8
  • Toll-like receptor 9
  • US10544143, Example 707
  • US10544143, Example 710
  • US10544143, Example 721
  • US10544143, Example 727
  • US10730877, Example 727
2 Ki 6 IC50 16 EC50
  • DNA dC->dU-editing enzyme APOBEC-3G
  • G protein signalling regulator 19
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • Hexokinase type I
  • RGS7
  • Regulator of G-protein signaling 8
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • putative hexokinase HKDC1
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
  • 3-chloranyl-N-(3,3-dimethylbutan-2-yl)-6-nitro-1-benzothiophene-2-carboxamide
  • 3-chloro-6-nitro-N-(1,2,2-trimethylpropyl)-1-benzothiophene-2-carboxamide
  • 3-chloro-6-nitro-N-(1,2,2-trimethylpropyl)benzothiophene-2-carboxamide
  • 3-chloro-N-(3,3-dimethylbutan-2-yl)-6-nitro-1-benzothiophene-2-carboxamide
  • MLS000583265
  • SMR000201101
  • cid_2971539
24 IC50
  • Heart phosphodiesterase
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 1
  • Phosphodiesterase 3
  • Phosphodiesterase 4
  • (CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one
  • 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one
  • 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one(CI-914)
  • 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one(Imazodan)
  • CHEMBL12831
  • CI-914
12 Ki 12 IC50
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Opioid receptors; mu & delta
  • 4-cyclopropylmethyl-14-iodo-(14R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-triene-10,17-diol(ioxy)
16 Ki 8 EC50
  • 5-hydroxytryptamine receptor 1A
  • Adrenergic receptor alpha-2
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Beta-1 adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • (1R,3S)-1-Aminomethyl-3-phenyl-isochroman-5,6-diol
  • 1-Aminomethyl-3-phenyl-isochroman-5,6-diol
  • A-70108
  • CHEMBL86931
23 Ki 1 Kd
  • Adenosine A1 receptor
  • Adenosine A2 receptor
  • Adenosine Receptors A2a (A2a)
  • Adenosine receptor A1
  • Adenosine receptor A2a
  • Adenosine receptor A2a and A3
  • Adenosine receptor A2b
  • Adenosine receptor A3
  • 2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetic acid
  • CHEMBL27041
  • [4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid
  • [4-(2,6-Dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid
24 IC50
  • Sodium channel alpha subunit
  • Sodium channel protein type 10 subunit alpha
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)
  • Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
  • CHEMBL3236329
24 IC50
  • Sodium channel alpha subunit
  • Sodium channel protein type 10 subunit alpha
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)
  • Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
  • CHEMBL3236343
22 Ki 2 IC50
  • 5-HT3A Serotonin Receptor
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • Alpha-1A adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Norepinephrine transporter
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • Synaptic vesicular amine transporter
  • (R)Methyl-(1-methyl-2-phenyl-ethyl)-amine
  • METHAMPHETAMINE
  • METHAMPHETAMINE (+)
  • METHAMPHETAMINE (-)
  • Methyl-(1-methyl-2-phenyl-ethyl)-amine
  • Methyl-(1-methyl-2-phenyl-ethyl)-amine(methamphetamine)
12 Ki 11 IC50 1 EC50
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Opioid receptor
  • Opioid receptors; mu/kappa/delta
  • CHEMBL216640
  • Dyn A(1-11)-NH2
  • Dynorphin A analogues
  • H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-NH2
  • HTyr-Gly-Gly-Phe-Leu-Arg-Arg-lle-Arg-Pro-LysNH2
  • Linear Dyn A-(1-11)NH2
  • Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-D-Lys-NH2
  • Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
2 IC50 22 EC50
  • Bile acid receptor
  • Nuclear receptor ROR-alpha
  • Nuclear receptor ROR-beta
  • Nuclear receptor ROR-gamma (RORC)
  • Nuclear receptor subfamily 1 group I member 2
  • Oxysterols receptor LXR-alpha
  • Oxysterols receptor LXR-beta
  • CHEMBL3263710
24 IC50
  • CDC7 and DBF4
  • CDK2/CycE
  • Casein kinase I isoform alpha
  • Casein kinase I isoform delta
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Serine/threonine-protein kinase pim-1
  • CHEMBL3261514
22 Ki 2 IC50
  • Adenosine A1 receptor
  • Adenosine A2 receptor
  • Adenosine A2a receptor
  • Adenosine Receptors A2a (A2a)
  • Adenosine receptor
  • Adenosine receptor A1
  • Adenosine receptor A2a and A3
  • Adenosine receptor A2b
  • Adenosine receptor A3
  • 4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid
  • 4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid:1/4 moles H2O
  • 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid
  • CHEMBL418333
12 Ki 12 IC50
  • Monoamine transporters; Norepininephrine & dopamine
  • Norepinephrine Monoamine transporters
  • Norepinephrine transporter
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • CHEMBL296602
  • Indatraline
  • [3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine
  • [3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine; hydrochloride
22 IC50 2 Kd
  • Death-associated protein kinase 2
  • Death-associated protein kinase 3
  • Serine/threonine-protein kinase 17A
  • Serine/threonine-protein kinase 17B (STK17B)
  • CHEMBL3334979
24 IC50
  • Neuraminidase
  • Sialidase
  • CHEMBL81717
  • Guanidino-Oseltamivir Carboxylicacid
21 Ki 3 IC50
  • AVPR1A
  • Oxytocin receptor
  • Vasopressin V1 receptor
  • Vasopressin V1a receptor
  • Vasopressin V2 Receptor
  • Vasopressin V2 receptor
  • Vasopressin receptor
  • CHEMBL296908
  • N-(3-(4-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidine-1-carbonyl)phenoxy)propyl)acetamide
  • N-(3-{4-[4-(2-Oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-propyl)-acetamide
  • OPC-1268
  • OPC-21268
24 Ki
  • 5-hydroxytryptamine receptor 1A
  • ADRA1A
  • ADRA1B
  • Adrenergic alpha1B
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Cerebral cortex alpha adrenergic receptor
  • D(2) dopamine receptor
  • 6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propylamino}-1,3,5-trimethyl-1H-pyrimidine-2,4-dione
  • CHEMBL420060
  • Urapidil-5-methyl
18 Ki 6 IC50
  • Adrenergic alpha1B
  • Adrenergic receptor alpha-2
  • Alpha adrenergic receptor 1A and 1B
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Bile salt export pump
  • Bile salt export pump (BSEP)
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cerebral cortex alpha adrenergic receptor
  • Multidrug resistance-associated protein 4
  • Serotonin (5-HT) receptor
  • adrenergic Alpha2
  • CHEMBL279516
  • INDORAMIN
  • INDORAMINE
  • INDORAMINN-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide
  • N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide
  • N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide (Indoramin)
  • N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide(indoramin)
14 Ki 10 EC50
  • GRM7
  • GRM8
  • Metabotropic glutamate receptor
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 3
  • Metabotropic glutamate receptor 4 (mGlu4)
  • Metabotropic glutamate receptor 4 (mGluR4)
  • Metabotropic glutamate receptor 5
  • Metabotropic glutamate receptor 6
  • Metabotropic glutamate receptor 6 (mGlu6)
  • Metabotropic glutamate receptor 7 (mGlu7)
  • Metabotropic glutamate receptor 8 (mGlu8)
  • (1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanecarboxylic acid
  • 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid
  • 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid(2S,3S,4S-CCG)
  • CHEMBL280563
  • L-CCGI
24 Ki
  • Adenosine A1 receptor
  • Adenosine A2 receptor
  • Adenosine A2a receptor
  • Adenosine A2b receptor
  • Adenosine Receptors A2a (A2a)
  • Adenosine receptor
  • Adenosine receptor A1
  • Adenosine receptor A2a
  • Adenosine receptor A2a and A3
  • Adenosine receptor A2b
  • Adenosine receptor A3
  • Adenosine receptors; A2a & A2b
  • 4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid
  • 4-(2,6-dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid
  • CHEMBL8565
24 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Serine/threonine-protein kinase PLK4
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 2
  • CHEMBL3353355
  • US10358436, Example A42
  • US9907800, Example A42
24 IC50
  • 5-hydroxytryptamine receptor 1A
  • Acetylcholinesterase
  • Adrenergic receptor alpha-2
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Calcium channel
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • Sodium-dependent noradrenaline transporter
  • CHEMBL29835
  • Indol-1-yl-propyl-pyridin-4-yl-amine
  • Indol-1-yl-propyl-pyridin-4-yl-amine(Besipirdine)
24 Ki
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • DRD1
  • Dopamine D1B
  • Dopamine receptor
  • 5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol
  • CHEMBL101446
  • Dihydrexidine
  • Dihydrexidine, DHX
7 Ki 17 IC50
  • GRM7
  • GRM8
  • Glutamate receptor ionotropic, kainate
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 3
  • Metabotropic glutamate receptor 4 (mGluR4)
  • Metabotropic glutamate receptor 5
  • (2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid
  • 2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid
  • CHEMBL39338
16 Ki 8 IC50
  • 5-HT3A Serotonin Receptor
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Norepinephrine transporter
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • (S)-Phenyl-(S)-piperidin-2-yl-acetic acid methyl ester; hydrochloride
  • CHEMBL542556
  • METHYLPHENIDATE
20 Ki 4 Kd
  • 5-hydroxytryptamine receptor 1A
  • Beta-2 adrenergic receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • (2R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol
  • (7-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium(R(+)7OH-DPAT)
  • (R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
  • (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol
  • (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol.HCl
  • 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol
  • CHEMBL301559
1 Ki 21 IC50 2 EC50
  • Adrenergic Alpha
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cytochrome P450 2J2
  • Multidrug resistance protein 1/Multidrug resistance associated protein 1
  • Multidrug resistance-associated protein 4
  • P-glycoprotein 1
  • Potassium channel protein TASK-1
  • Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium channel protein type 5 subunit alpha
  • Solute carrier family 22 member 1
  • Sterol 14α-demethylase (CYP51)
  • Twik-RElated Potassium (K+) channel 1 (TREK1)
  • Voltage-dependent L-type calcium channel subunit alpha-1C
  • 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one
  • 1-[2-(2-Hydroxy-3-propylamino-propoxy)-phenyl]-3-phenyl-propan-1-one
  • 1-[2-(2-Hydroxy-3-propylamino-propoxy)-phenyl]-3-phenyl-propan-1-one (propafenone)
  • 1N-[2-(5-dimethylaminomethyl-2-furylmethylsulfanyl)ethyl]-1N-methyl-2-nitro-(Z)-1-ethene-1,1-diamine
  • CHEMBL631
  • GNF-Pf-4594
  • PROPAFENONE
  • Rythmol
7 Ki 17 IC50
  • Calpain 1/2
  • Calpain 1/small subunit 1
  • Calpain1/2
  • Cathepsin B
  • Cathepsin D
  • Falcipain 2B
  • Falcipain-2
  • Pro-cathepsin H
  • Procathepsin L
  • (S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid
  • CHEMBL423112
  • MDL-28170
  • [(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester
  • [1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester
  • [1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester
  • benzyl (2S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate
  • benzyl (S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate
15 Ki 9 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • NK-3 receptor
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Potassium voltage-gated channel subfamily H member 2
  • CHEMBL3422017
  • US10065961, Compound 23
  • US10683295, Compound 23
  • US9475814, 23
8 Ki 16 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • NK-3 receptor
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neuromedin-K receptor
  • Potassium voltage-gated channel subfamily H member 2
  • CHEMBL3422018
  • US10065961, Compound 24
  • US9475814, 24
12 Ki 12 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Potassium voltage-gated channel subfamily H member 2
  • Transcriptional regulator ERG
  • CHEMBL3422012
  • US10065961, Compound 3
  • US10683295, Compound 3
  • US9475814, 3
2 Ki 8 IC50 8 Kd 6 EC50
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • HMG-CoA reductase
  • Liver fatty acid binding protein (rat L-FABP)
  • Multidrug resistance-associated protein 4
  • Organic anion-transporting polypeptide 1D1 (Oatp1d1)
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor gamma
  • 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester
  • 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
  • CHEMBL565
  • Clofibrate
  • EPIB
  • ETHYL CLOFIBRATE
  • Ethyl 2-(p-chlorophenoxy)isobutyrate
  • Ethyl chlorophenoxyisobutyrate
  • Liprin
  • alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester
  • alpha-p-Chlorophenoxyisobutyryl ethyl ester
  • ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
16 Ki 8 EC50
  • GRIA1
  • GRIA2
  • GRIK1
  • Glutamate receptor ionotropic AMPA
  • Glutamate receptor ionotropic kainate
  • Glutamate receptor ionotropic, kainate 1
  • Glutamate receptor ionotropic, kainate 2
  • Glutamate-Kainate 7
  • Grik5
  • (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pentanedioic acid
  • CHEMBL301536
  • E-2-Amino-4-(3-naphthalen-2-yl-allyl)-pentanedioic acid(LY339434)
  • LY-339434
24 Ki
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • 11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{15,20}]henicosa-1(14),3(8),4,6,15,17,19-heptaene
  • 7-Methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]-benzazecine
  • 7-methyl-6,7,8,9,14,15-hexahydro-5H-benzo[7,8]azecino[5,4-b]indole(LE 300)
  • 7-methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]benzazecine
  • CHEMBL441618
  • LE 300
1 Ki 20 IC50 3 EC50
  • Androgen Receptor
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • Glucocorticoid receptor
  • Mineralocorticoid receptor
  • Progesterone receptor
  • Sodium-dependent dopamine transporter
  • CHEMBL3581693
23 IC50 1 EC50
  • DNA polymerase
  • DNA polymerase (alpha/delta/epsilon)
  • DNA polymerase alpha subunit
  • DNA polymerase beta
  • DNA polymerase catalytic subunit
  • DNA polymerase delta subunit 1
  • DNA polymerase gamma subunit 1
  • DNA polymerase lambda
  • Human herpesvirus 1 DNA polymerase
  • Human herpesvirus 6 DNA polymerase
  • Nuclear receptor ROR-alpha
  • Steroidogenic Factor 1
  • 3alpha,16,17,18-tetrahydroxyaphidicolone
  • 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
  • 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R,10S,12R,13R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol (Aphidicolin)
  • 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R,10S,12R,13R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol(Aphidicolin)
  • CHEMBL29711
  • aphidicholin
  • aphidicolin
  • cid_457964
22 IC50 2 Kd
  • Cytochrome P450 3A
  • Dual specificity mitogen-activated protein kinase kinase 1
  • Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase
  • Dual specificity mitogen-activated protein kinase kinase; MEK1/2
  • MAP kinase ERK1
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase 3
  • Mitogen-activated protein kinase; ERK1/ERK2
  • CHEMBL3590107
  • US10525036, Example SCH772984
24 IC50
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • CHEMBL70176
  • N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-benzamide
  • N-hydroxy-2-(4-methoxy-N-(pyridin-3-ylmethyl)phenylsulfonamido)-3-methylbenzamide
7 Ki 17 IC50
  • Axin-1/Glycogen synthase kinase-3 beta
  • CDK2/CycE
  • CDK2/Cyclin A/Cyclin A1
  • CDK3/E
  • CDK6/CycD3
  • CDK7/Cyclin H/MNAT1
  • Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Cyclin-Y
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 9
  • AT-7519
21 Ki 3 IC50
  • Acetylcholinesterase
  • Adrenergic receptor alpha-2
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • DRD1
  • Dopamine D1 receptor
  • HTR4
  • Potassium voltage-gated channel subfamily H member 2
  • Serotonin 2 (5-HT2) receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
  • 4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-methoxy-benzamide
  • 4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-methoxy-benzamide(Clebopride)
  • 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-2-methoxybenzamide
  • CHEMBL325109
  • Clebopride
12 Ki 4 IC50 8 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • Serotonin 1 (5-HT1) receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • (R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
  • (R)-2-(4-Iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine
  • (R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine
  • CHEMBL134519
16 Ki 8 EC50
  • Prostaglandin E2 receptor
  • Prostaglandin E2 receptor EP1 subtype (EP1)
  • Prostaglandin E2 receptor EP2 subtype
  • Prostaglandin E2 receptor EP4 subtype
  • Prostanoid EP1 Receptor
  • Prostanoid EP2 Receptor
  • Prostanoid EP2 receptor
  • Prostanoid EP3 Receptor
  • Prostanoid EP4 Receptor
  • Prostanoid EP4 receptor
  • 7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid
  • 8-aza-11-deoxyprostaglandin E1
  • CHEMBL42027
12 Ki 12 IC50
  • Melanocortin receptor 4
  • 2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-4,5-dihydro-1H-imidazole
  • 2-phenylimidazoline
  • 2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-fluoro-phenyl}-4,5-dihydro-1H-imidazole
  • CHEMBL40711
  • ML-253764
24 IC50
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • (2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL
  • (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol
  • CHEMBL304552
6 IC50 18 EC50
  • Bile acid receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2A6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Glucocorticoid
  • Nuclear receptor ROR-alpha
  • Nuclear receptor ROR-beta
  • Nuclear receptor ROR-gamma
  • Nuclear receptor ROR-gamma (RORC)
  • Oxysterols receptor LXR-alpha
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor delta
  • Progesterone receptor
  • Retinoic acid receptor RXR-alpha
  • Retinoid receptor
  • Steroidogenic Factor 1
  • Vitamin D3 receptor
  • CHEMBL3774855
20 Ki 4 IC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • CHEMBL180010
  • N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-(pyridin-2-yl)benzamide
  • N-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-4-pyridin-2-yl-benzamide
  • PG-01037
24 IC50
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase 16
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Pseudolysin
  • Stromelysin-1
  • Thermolysin
  • (R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydroxy-3-methyl-butyramide
  • (R)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
  • CHEMBL179288
16 Ki 7 IC50 1 EC50
  • Apoptosis regulator Bcl-2
  • Apoptosis regulator Bcl-2/Bcl-2 homologous antagonist/killer
  • BCL-W
  • Bcl-2-like protein 1
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • ABT-199
  • VENETOCLAX
  • Venetoclax
4 IC50 20 Kd
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
  • Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
  • CHEMBL3928423
  • US10087187, Compound 66
24 IC50
  • Adrenergic receptor alpha-2
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Dopamine receptor
  • Tissue inhibitor of metalloproteinases-3
  • Norprolac
  • QUINAGOLIDE
12 Ki 9 IC50 3 EC50
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Multidrug resistance-associated protein 4
  • (-)-17-(cyclobutylmethyl)morphinan-3,14-diol
  • (-)-N-cyclobutylmethyl-3,14-dihydroxymorphinan
  • (-)-butorphanol
  • 17-(cyclobutylmethyl)morphinan-3,14-diol
  • BUTORPHANOL
  • CHEMBL33986
  • US10231963, Table B.3
  • US10736890, Compound TABLE B.3
  • US9656961, Example 00120
24 IC50
  • ITGA5/ITGB1
  • Integrin alpha-2/beta-3
  • Integrin alpha-3/beta-3
  • Integrin alpha-IIb/beta-3
  • (6S,12S,15S)-1,6-diamino-12-(carboxymethyl)-16-hydroxy-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecane-15-carboxylic acid
  • (S)-3-[2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-((R)-1-carboxy-2-hydroxy-ethyl)-succinamic acid
  • (S)-3-[2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-((S)-1-carboxy-2-hydroxy-ethyl)-succinamic acid
  • 2-[1-[1-amino-4-amino(imino)methylamino-(1S)-butylcarboxamidomethylcarboxamido]-2-carboxy-(1S)-ethylcarboxamido]-3-hydroxy-(2S)-propanoic acid
  • 2-{1-[1-amino-4-amino(imino)methylaminobutylcarboxamidomethylcarboxamido]-2-carboxyethylcarboxamido}-3-hydroxypropanoic acid
  • 3-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-(1-carboxy-2-hydroxy-ethyl)-succinamic acid
  • 3-[2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-((S)-1-carboxy-2-hydroxy-ethyl)-succinamic acid
  • 3-[2-(2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-(1-carboxy-2-hydroxy-ethyl)-succinamic acid
  • 3-[2-(2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-(1-carboxy-2-hydroxy-ethyl)-succinamic acid (RGDS)
  • CHEMBL265628
  • RGDS
9 Ki 15 EC50
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2 and M4
  • Muscarinic acetylcholine receptor M3
  • CHEMBL4091934
19 Ki 5 IC50
  • Cereblon/Histone deacetylase 1
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 8
  • Histone deacetylase 9
  • CHEMBL491316
  • N-hydroxy-3-(2-phenethyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-5-yl)acrylamide
  • N-hydroxy-3-[2-phenethyl-1-(2-pyrrolidin-1-ylethyl)-1H-benzimidazol-5-yl]acrylamide
  • SB-639
  • US10201527, Compound 72
  • US10736881, Compound 72
  • US8551988, 72
15 IC50 9 EC50
  • CDK7/Cyclin H/MNAT1
  • CDK8/Cyclin C
  • Cyclin-dependent kinase 11B
  • Discoidin domain-containing receptor 2
  • Epithelial discoidin domain-containing receptor 1
  • MAP kinase-interacting serine/threonine-protein kinase 1/2
  • Macrophage colony-stimulating factor 1 receptor (CSF1R)
  • Mast/stem cell growth factor receptor Kit
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 3
  • CHEMBL4101411
3 Ki 6 IC50 15 EC50
  • Excitatory amino acid transporter 1
  • Excitatory amino acid transporter 2
  • Excitatory amino acid transporter 3
  • GRM7
  • Metabotropic glutamate receptor
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 3
  • Metabotropic glutamate receptor 4 (mGlu4)
  • Metabotropic glutamate receptor 6 (mGlu6)
  • Metabotropic glutamate receptor 7 (mGlu7)
  • Metabotropic glutamate receptor 8 (mGlu8)
  • (1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid
  • (2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid
  • CHEMBL482081
22 Ki 2 IC50
  • Cathepsin G
  • Coagulation factor X
  • Coagulation factor XI
  • Coagulation factor XII
  • Complement C1s
  • Granzyme B
  • Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein
  • Kallikrein 1
  • Kallikrein 14
  • Kallikrein 2
  • Kallikrein 5
  • Kallikrein 6
  • Kallikrein-12
  • Kallikrein-13
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Thrombin and coagulation factor VII
  • Vitamin K-dependent protein C
  • CHEMBL4094403
22 Ki 2 IC50
  • Cathepsin G
  • Coagulation factor X
  • Coagulation factor XI
  • Coagulation factor XII
  • Complement C1s
  • Granzyme B
  • Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein
  • Kallikrein 1
  • Kallikrein 14
  • Kallikrein 2
  • Kallikrein 5
  • Kallikrein 6
  • Kallikrein-12
  • Kallikrein-13
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Thrombin and coagulation factor VII
  • Vitamin K-dependent protein C
  • CHEMBL4059991
16 Ki 6 IC50 2 EC50
  • Adrenergic receptor alpha
  • Alpha adrenergic receptor (1a and 1d)
  • Alpha-1A adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M1 and M3
  • Muscarinic acetylcholine receptor M2 and M4
  • Muscarinic acetylcholine receptor M2 and M5
  • Muscarinic acetylcholine receptor M5
  • Sigma-1 receptor
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • CHEMBL4072818
24 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 3A
  • 5-hydroxytryptamine receptor 5A
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Adrenergic alpha1B
  • Alpha-2A adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Beta-3 adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(4) dopamine receptor
  • Histamine H1 receptor
  • Histamine H2 Receptor
  • Histamine H3 receptor
  • Mu-type opioid receptor
  • Serotonin (5-HT) receptor
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • (3-(2-Fluoroethoxy)-2-methoxyphenyl)-(1-(2-p-toluylphenylethyl)-piperidine-4-yl)-methanol
  • CHEMBL476839
4 Ki 20 IC50
  • Bacterial beta-lactamase TEM
  • Beta-lactamase
  • Beta-lactamase OXA-1
  • Beta-lactamase pse-1
  • Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
  • Histone acetyltransferase KAT5
  • Histone acetyltransferase KAT8
  • Histone acetyltransferase PCAF
  • Histone acetyltransferase p300
  • Lipoxygenase-1
  • cis-Decaprenyl diphosphate synthase (cis-DPPS)
  • 2-Hydroxy-6-pentadecyl-benzoic acid
  • 2-Pentadecyl-6-hydroxybenzoic acid
  • 2-hydroxy-6-((8Z,11Z)-pentadeca-8,11,14-trienyl)benzoic acid
  • 2-hydroxy-6-pentadecylbenzoic acid
  • 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid
  • 6-pentadecatrienylsalicylic acid
  • 6-pentadecylsalicylic acid
  • 6-{8(Z),11(Z),14-pentadecatrienyl}salicylic acid
  • 6[8'(Z ),11'(Z ),14'-pentadecatrienyl]salicylicacid
  • BPH-953
  • CHEMBL455368
  • anacardic acid
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