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Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
7 Ki 23 IC50
  • α-galactosidase
  • α-glucosidase
  • β-galactosidase
  • Beta-galactosidase
  • Beta-glucosidase
  • Ceramide glucosyltransferase
  • Lysosomal acid glucosylceramidase
  • Probable alpha-glucosidase Os06g0675700
  • Sucrase-isomaltase
  • alpha-Glucosidase (alpha-Glu)
  • alpha-glucosidase (Gaa)
  • (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol
  • N-Nonyl-DNJ
30 EC50
  • Bile acid receptor
  • Bile acid receptor FXR
  • G-protein coupled bile acid receptor 1
  • (4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethyl-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
  • 6-ECDCA
  • 6-ethyl chenodeoxycholic acid
  • 6-ethyl-3,7-dihydroxycholan-24-oic acid
  • 6ECDCA
  • 6alpha-Ethyl-Chenodeoxycholic Acid
  • INT-747
  • INT747
  • Ocaliva
  • US10208081, E6-ECDCA
  • US10266560, Example 6-ECDCA
  • obeticholic acid
22 Ki 1 IC50 7 EC50
  • HRH3
  • Histamine H3 receptor
  • Histamine H4 receptor
  • 2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide
  • CHEMBL19439
  • CHEMBL544911
  • Imetit
  • {[2-(1H-imidazol-4-yl)ethyl]sulfanyl}methanimidamide
1 Ki 19 IC50 3 Kd 7 EC50
  • Aldo-keto reductase family member 1B10 (AKR1B10)
  • Aldose reductase (AR)
  • Botulinum neurotoxin type A
  • DNA polymerase beta
  • G-protein coupled bile acid receptor 1
  • GP41
  • Glycogen phosphorylase, muscle form
  • Human immunodeficiency virus type 1 protease
  • Hypoxia-inducible factor prolyl hydroxylase
  • Nonstructural protein 5
  • Nuclear factor NF-kappa-B
  • Oxysterols receptor LXR-alpha
  • Oxysterols receptor LXR-beta
  • Pancreatic alpha-amylase
  • Peroxisome proliferator-activated receptor gamma
  • Phosphodiesterase isozyme 4
  • Protease
  • SUMO1 activating enzyme subunit 1
  • Serum albumin
  • Zinc finger protein GLI1
  • (1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-17-hydroxy-1,2,14,18,18-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0^{2,10}.0^{5,9}.0^{14,19}]henicosane-5-carboxylic acid
  • Betulinic Acid, 24
  • CHEMBL269277
  • cid_64971
30 IC50
  • C-C chemokine receptor type 4
  • C-C chemokine receptor type 6 (CCR6)
  • C-X-C chemokine receptor type 1
  • C-X-C chemokine receptor type 2
  • chemokine (C-X-C motif) receptor 3
  • US9388149, 2 (Diastereoisomer 1)
  • US9388149, 2 (Diastereoisomer 2)
  • US9388149, 2 (Enantiomer 1 of diastereoisomer 1)
  • US9388149, 2 (Enantiomer 1 of diastereoisomer 2)
  • US9388149, 2 (Enantiomer 2 of diastereoisomer 1)
  • US9388149, 2 (Enantiomer 2 of diastereoisomer 2)
  • US9580412, Example 2
20 Ki 7 IC50 3 EC50
  • PTGER3
  • PTGER4
  • PTGIR
  • Prostaglandin D Synthase
  • Prostaglandin E2 receptor
  • Prostaglandin E2 receptor EP1 subtype (EP1)
  • Prostaglandin E2 receptor EP2 subtype
  • Prostaglandin E2 receptor EP4 subtype
  • Prostaglandin F2-alpha receptor
  • Prostaglandin Transporter
  • Prostanoid DP receptor
  • Prostanoid EP1 Receptor
  • Prostanoid EP2 Receptor
  • Prostanoid EP3 Receptor
  • Prostanoid IP receptor
  • 5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoic acid
  • CHEMBL494
  • ILOPROST
  • Ventavis
  • [3H]-Iloprost
30 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Lysine-specific histone demethylase 1A
  • N-cyclopentyl-5- ((1R,2R)-2- (tetrahydro-2H- pyran-4-ylamino)- cyclopropyl)thio- phene-3-carboxamide
  • US10053456, 38
  • US10053456, 39
  • US10414761, Example 39
  • US9718814, 39
  • US9920047, 39
30 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Lysine-specific histone demethylase 1A
  • 5-((1R,2R)-2- (cyclobutylamino)- cyclopropyl)-N- (tetrahydro-2H- pyran-4- yl)thiophene-3- carboxamide
  • US10053456, 42
  • US10053456, 43
  • US10414761, Example 43
  • US9718814, 43
  • US9920047, 43
30 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Lysine-specific histone demethylase 1A
  • 5-((1R,2R)-2-(cis- (4-aminocyclohexyl)- amino)cyclopropyl)- N-(4,4- difluorocyclohexyl)- thiophene-3- carboxamide or5-((1R,2R)-2-(trans-(4-aminocyclohexyl)-amino)cyclopropyl)-N-(4,4-difluorocyclohexyl)-thiophene-3-carboxamide
  • US10053456, 45
  • US10053456, 46
  • US10414761, Example 46
  • US9718814, 46
  • US9920047, 46
30 IC50
  • Coagulation factor XI
  • Plasma kallikrein
  • US10183932, Example 144
  • US9434690, 125
  • US9434690, 141
  • US9434690, 142
  • US9434690, 143
  • US9434690, 144
  • US9822102, Example 144
15 Ki 15 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10329256, Example 2
  • US9487512, 2
  • US9944601, Example 2
30 IC50
  • Lysine-specific histone demethylase 1A
  • 4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-methoxy-phenyl)-1- methyl-6-oxo-1,6-dihydro- pyrimidin-4-yl]-2-fluoro- benzonitrile
  • US10023543, Example 7
  • US10023543, Example 85
  • US10023543, Example 86
  • US10207999, Example 86
  • US10328077, Example 86
  • US10548896, Example 86
  • US10849898, Example 86
  • US9573930, Example 86
  • US9771329, Example 86
  • US9776974, Example 86
27 IC50 3 EC50
  • Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH).
  • Bcl-2-related protein A1
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Gag-Pol polyprotein
  • Heat Shock 70kDa Protein 1
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • MKP-3
  • diphosphomevalonate decarboxylase
  • glutathione S-transferase
  • heat shock 70kDa protein 8 isoform 1
  • nuclear receptor subfamily 4, group A, member 1
  • MLS000050353
  • N-(2,3-di-2-furyl-6-quinoxalinyl)-1-azepanecarboxamide
  • N-[2,3-bis(2-furanyl)-6-quinoxalinyl]-1-azepanecarboxamide
  • N-[2,3-bis(2-furyl)quinoxalin-6-yl]azepane-1-carboxamide
  • N-[2,3-bis(furan-2-yl)quinoxalin-6-yl]azepane-1-carboxamide
  • SMR000077614
  • cid_2214811
1 Ki 29 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Bile salt export pump
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Sodium channel alpha subunit
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Voltage-gated sodium channel
  • 4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridin-3-yl)-2-Fluoro-5-Methoxy-N-(Methylsulfonyl)Benzamide
  • 4-(5-chloro-6-(2,5-difluorophenoxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide
  • US9663508, Example 705
5 Ki 12 IC50 13 EC50
  • G protein signalling regulator 19
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • MPI protein
  • Multidrug resistance protein 1/Multidrug resistance associated protein 1
  • POsterior Segregation family member (pos-1)
  • RGS7
  • RecName: Full=Zinc finger protein mex-5
  • Regulator of G-protein signaling 8
  • TCRAV4S1
  • Trypanosoma brucei RNA editing ligase 1
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • lens epithelium-derived growth factor p75
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
  • serum albumin precursor
  • (4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-1,3-thiazol-3-yl)amino]methylidene]cyclohexa-2,5-dien-1-one
  • (4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-3-thiazolyl)amino]methylidene]-1-cyclohexa-2,5-dienone
  • (4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-4-thiazolin-3-yl)amino]methylene]cyclohexa-2,5-dien-1-one
  • (4E)-4-[[(4-methyl-2-methylimino-1,3-thiazol-3-yl)amino]methylidene]-2,3-bis(oxidanyl)cyclohexa-2,5-dien-1-one
  • (4Z)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-4-thiazolin-3-yl)amino]methylene]cyclohexa-2,5-dien-1-one
  • MLS000564160
  • SMR000151701
  • cid_5834362
27 Ki 1 IC50
0 ΔG°
  • α-Carbonic anhydrase (αCA)
  • β-Carbonic anhydrase (βCA)
  • Alpha-carbonic anhydrase
  • Astrosclerin-3
  • Beta-carbonic anhydrase
  • Carbonic Anhydrase VA
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 9
  • Gamma-carbonic anhydrase
  • Sodium/iodide cotransporter
  • perchlorate
  • sodium perchlorate
27 Ki 3 IC50
  • DNA repair protein RAD51 homolog 1
  • Myristoyl-CoA:protein N-myristoyltransferase (Nmt)
  • 2-[(veratroylhydrazono)methyl]benzoic acid
  • 2-[[(3,4-dimethoxybenzoyl)hydrazinylidene]methyl]benzoic acid
  • 2-[[(3,4-dimethoxyphenyl)carbonylhydrazinylidene]methyl]benzoic acid
  • 2-[[[(3,4-dimethoxyphenyl)-oxomethyl]hydrazinylidene]methyl]benzoic acid
  • MLS000774113
  • SC-58272
  • SMR000365110
  • cid_958176
28 IC50 2 Kd
  • Cytoplasmic tyrosine-protein kinase BMX
  • Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase
  • Dual specificity mitogen-activated protein kinase kinase 5
  • FLT3-ITD
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine-protein kinase BRK
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase Blk
  • Tyrosine-protein kinase CSK
  • Tyrosine-protein kinase FRK
  • Tyrosine-protein kinase Fgr
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase Fyn (Y531F)
  • Tyrosine-protein kinase Fyn Isoform B
  • Tyrosine-protein kinase HCK
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
  • Tyrosine-protein kinase Yes
  • flt3
  • (3R,4S)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1,2-dithiolan-4-ol
  • US10844038, Example 43 B.
0 ΔG°
  • cyclohexanol
  • cyclohexanol-d12
16 Ki 13 IC50 1 Kd
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neuromedin-K receptor
  • (+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
  • (+)-(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
  • (+/-)(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
  • (-) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
  • (-)-(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
  • (2-Methoxy-benzyl)-((1R,4S)-2-phenyl-piperidin-4-yl)-amine
  • (2-Methoxy-benzyl)-((2S,3S)-2-phenyl-piperidin-3-yl)-amine
  • (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
  • (2S,3S)-3-(2-Methoxy-benzyloxy)-2-phenyl-piperidine
  • (2S,3S)-N-(2-methoxybenzyl)-2-phenylpiperidin-3-amine
  • CHEMBL2114310
  • CHEMBL441225
  • CP 99994
  • CP-99994
  • Tritiated-(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
30 IC50
  • ALK tyrosine kinase receptor
  • Axin-1/Glycogen synthase kinase-3 beta
  • CaM kinase IV
  • Homeodomain-interacting protein kinase 1
  • Homeodomain-interacting protein kinase 2 (HIPK2)
  • Homeodomain-interacting protein kinase 3
  • MAP kinase-activated protein kinase 3
  • MAP kinase-activated protein kinase 5
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 3
  • Mitogen-activated protein kinase 8
  • Myotonin-protein kinase
  • PAK 1/CDC42
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase 24
  • Serine/threonine-protein kinase AKT
  • Serine/threonine-protein kinase AKT2
  • Serine/threonine-protein kinase MARK1
  • Serine/threonine-protein kinase MST4
  • Serine/threonine-protein kinase Nek1
  • Serine/threonine-protein kinase Nek2
  • Serine/threonine-protein kinase VRK1
  • Serine/threonine-protein kinase c-TAK1
  • Serine/threonine-protein kinase pim-2
  • Tyrosine-protein kinase BRK
  • Tyrosine-protein kinase JAK3
  • p21-Activated kinase 2 (PAK2)
  • p21-Activated kinase 3 (PAK3)
  • CHEMBL3133821
30 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • Adrenergic alpha1B
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2C adrenergic receptor
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(4) dopamine receptor
  • Histamine H1 receptor
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • (1-Phenethyl-piperidin-4-yl)-phenyl-methanol
  • CHEMBL18972
  • Glemanserin
  • MDL 11,939
  • MDL-11939
21 Ki 3 IC50 6 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • Serotonin (5-HT) receptor
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • 3-(2-aminopropyl)-1H-indol-5-ol
  • CHEMBL275854
  • alpha-M-5-HT
  • alpha-methyl-5-HT
  • alpha-methyl-5-hydroxytryptamine
  • alpha-methylserotonin
6 Ki 15 IC50 2 Kd 7 EC50
  • 1,3-beta-glucan synthase component GLS2
  • 3C-like proteinase
  • 3C-like proteinase (3CL-PRO)
  • Adrenergic Alpha
  • Angiopoietin-1 receptor
  • Bile salt export pump
  • Calcium channel
  • Calmodulin
  • Carboxylesterase 2
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Menin/Histone-lysine N-methyltransferase MLL
  • Mu-type opioid receptor
  • Neuropeptide Y receptor type 1
  • Nociceptin receptor
  • Opioid receptors; mu & delta
  • P-glycoprotein 1
  • Replicase polyprotein 1ab
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type I I alpha subunit
  • 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide
  • 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide
  • 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide(loperamide)
  • CHEMBL841
  • Imodium
  • LOPERAMIDE
  • LOPERAMIDE HYDROCHLORIDE
  • cid_71420
  • med.21724, Compound 184
2 Ki 28 IC50
  • JAK1 (aa 866-1154)
  • JAK1/JAK2/TYK2
  • JAK1/TYK2
  • JAK2 (aa 808-1132)
  • JAK2/TYK2
  • JAK3 (aa 811-1124)
  • JAK3/JAK1
  • Non-receptor tyrosine-protein kinase TYK2
  • TYK2 (aa 888-1187)
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • DECERNOTINIB
  • US10112907, Example 00017
  • US10766894, Compound TABLE 1.2
  • VRT-831509
  • VX-509
12 Ki 2 IC50 16 EC50
  • 5-hydroxytryptamine receptor 1A
  • Adrenergic alpha1B
  • Adrenergic receptor
  • Adrenergic receptor alpha
  • Adrenergic receptor alpha-2
  • Alpha adrenergic receptor (1a and 1d)
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Imidazoline I1
  • Imidazoline receptor 1 (I1R)
  • Nischarin
  • 2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole
  • 2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole (cirazoline)
  • CHEMBL13852
  • CIRAZOLINE
7 Ki 19 IC50 4 Kd
  • Bile salt export pump
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Envelope glycoprotein
  • Monoamine transporters; Norepininephrine & dopamine
  • Multidrug resistance protein 1/Multidrug resistance associated protein 1
  • Norepinephrine Monoamine transporters
  • Sigma non-opioid intracellular receptor 1
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • Transcriptional activator protein luxR
  • (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
  • (1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine
  • CHEMBL809
  • SERTRALINE
30 IC50
  • Dihydrofolate Reductase (DHFR)
  • Dihydrofolate reductase
  • Dihydrofolate reductase (DHFR)
  • 5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine
  • CHEMBL23532
30 IC50
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase (2 and 3)
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase 7
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-9
  • Stromelysin-1
  • CHEMBL3358155
30 IC50
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase (2 and 3)
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase 7
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-9
  • Stromelysin-1
  • CHEMBL3358158
30 Ki
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Dopamine D1 receptor
  • Dopamine D1B
  • Dopamine receptor
  • HTR6
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • Serotonin (5-HT) receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine
  • 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine(fluperlapine)
  • CHEMBL63756
  • Fluperlapine
1 Ki 11 IC50 8 Kd 10 EC50
  • Inositol 1,4,5-trisphosphate binding protein
  • Inositol 1,4,5-trisphosphate receptor
  • Inositol 1,4,5-trisphosphate receptor type 1
  • Inositol 1,4,5-trisphosphate receptor type 2
  • Inositol 1,4,5-trisphosphate receptor type 3
  • Inositol-trisphosphate 3-kinase A
  • Type 1 InsP3 receptor isoform S2
  • Type I inositol-1,4,5-trisphosphate 5-phosphatase
  • 1,4,5-Insp3
  • 1D-myo-inositol 1,4,5-triphosphate
  • 1D-myo-inositol 1,4,5-tris(dihydrogen phosphate)
  • 1D-myo-inositol 1,4,5-trisphosphate
  • 3,5,6-trioxyphosphate-1,2,4-cyclohexanetriol
  • CHEMBL279107
  • D-myo-inositol 1,4,5-trisphosphate
  • IP3
  • InsP3
2 Ki 2 IC50 4 Kd 22 EC50
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor delta
  • Peroxisome proliferator-activated receptor gamma
  • 5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-methoxy-N-(4-trifluoromethyl-benzyl)-benzamide
  • 5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-methoxy-N-(4-trifluoromethyl-benzyl)-benzamide(KRP297)
  • CHEMBL24458
  • KRP-297
30 IC50
  • BRAF/CRAF
  • Dual specificity mitogen-activated protein kinase kinase 5
  • Ephrin type-A receptor 2
  • Ephrin type-B receptor 4
  • Eukaryotic translation initiation factor 2-alpha kinase 4
  • Interleukin-1 receptor-associated kinase 1
  • MAP kinase p38
  • Mitogen-activated protein kinase kinase kinase 1
  • Mitogen-activated protein kinase kinase kinase kinase 5
  • Mixed lineage kinase 7
  • Protein cereblon/BRAF
  • Proto-oncogene tyrosine-protein kinase Src
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF serine/threonine protein kinase
  • Serine/threonine-protein kinase A-Raf
  • Serine/threonine-protein kinase B-raf
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase CSK
  • Tyrosine-protein kinase Fyn
  • Vascular endothelial growth factor receptor 2
  • CHEMBL3577124
1 Ki 29 IC50
  • Adrenergic receptor alpha-2
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Bile salt export pump
  • Calcium channel (Type L)
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2J2
  • Cytochrome P450 3A
  • Multidrug resistance protein 1/Multidrug resistance associated protein 1
  • Multidrug resistance-associated protein 4
  • Quinolone resistance protein norA
  • Voltage-dependent L-type calcium channel subunit alpha-1S
  • CHEBI:7550
  • NICARDIPINE
  • Nicardipine
30 Ki
  • 72 kDa type IV collagenase
  • ADAM17
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 15
  • Matrix metalloproteinase 16
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • (8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide]
  • (8S,11R,12S)-N12-hydroxy-N8-(2-morpholino-2-oxoethyl)-2,10-dioxo-11-((2'-(trifluoromethyl)biphenyl-4-yl)methyl)-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamide
  • 2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide]
  • CHEMBL325163
2 Ki 28 IC50
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cytochrome P450 2J2
  • Multidrug resistance-associated protein 4
  • Potassium channel protein TASK-1
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium channel alpha subunit
  • Sodium channel protein type 10 subunit alpha
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 7 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Sodium channel protein type I I alpha subunit
  • Twik-RElated Potassium (K+) channel 1 (TREK1)
  • Voltage-gated L-type calcium channel
  • Voltage-gated sodium channel alpha subunit Nav1.1
  • Voltage-gated sodium channel subunit alpha Nav1.8
  • 1-(2,6-dimethylphenoxy)-2-propanolamine
  • 1-(2,6-dimethylphenoxy)propan-2-amine
  • 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine
  • 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine(mexiletine)
  • CHEMBL558
  • MEXILETINE
  • Mexitil
17 IC50 13 EC50
  • Oxysterols receptor LXR-alpha
  • Oxysterols receptor LXR-beta
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor delta
  • 2-(3-chloro-4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propylthio)phenyl)acetic acid
  • CHEMBL23296
  • {3-Chloro-4-[3-(7-propyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid
  • {3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)sulfanyl]phenyl}acetic acid
24 Ki 3 IC50 3 EC50
  • NR2B Channel Blocker
  • Peroxisome Proliferator-Activated Receptor gamma/Retinoid X receptor alpha
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor gamma
  • Retinoic acid receptor RXR-alpha
  • Retinoic acid receptor alpha
  • Retinoic acid receptor gamma
  • Retinoid X receptor alpha
  • Retinoid X receptor beta
  • Retinoid X receptor gamma
  • Retinoid X receptor gamma/retinoic acid receptor alpha
  • Retinoid receptor
  • (2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
  • 7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
  • CHEMBL42314
30 IC50
  • Somatostatin receptor type 1
  • Somatostatin receptor type 2
  • Somatostatin receptor type 3
  • Somatostatin receptor type 4
  • Somatostatin receptor type 5
  • (4S,7R,10S,13R,16S,22S,25R)-25-amino-13-(4-aminobutyl)-18-[benzoyl(methyl)carbamoyl]-7,22-dibenzyl-4-carboxy-10-[(1R)-1-hydroxyethyl]-16-(1H-indol-3-ylmethyl)-6,9,12,15,21,24-hexaoxo-1,2-dithia-5,8,11,14,17,18,20,23-octaazacyclohexacosan-19-olate
  • Peptide analogue
7 Ki 21 IC50 2 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 7
  • Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
  • Adrenergic receptor alpha-1
  • Adrenergic receptor alpha-2
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Dopamine receptor
  • HTR1D
  • HTR4
  • HTR6
  • Serotonin (5-HT) receptor
  • Serotonin 1B/1D receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent serotonin transporter
  • 5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide
  • CHEMBL439849
  • VILAZODONE
26 Ki 2 IC50 2 Kd
  • Acetylcholinesterase
  • HRH3
  • Histamine H2 Receptor
  • Histamine H3 receptor
  • Histamine H4 receptor
  • 1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine
  • 1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine
  • 1-[3-(4-hexahydro-1-pyridinylmethylphenoxy)propyl]hexahydropyridine
  • 1-[4-(3-hexahydro-1-pyridinylpropoxy)benzyl]hexahydropyridine
  • CHEMBL129542
  • JNJ-5207852
30 IC50
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • ADAMTS1
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase 12
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • Tumor necrosis factor
  • (2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid hydroxyamide
  • CHEMBL187092
2 Ki 28 IC50
  • Angiopoietin-1 receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Ephrin type-B receptor 4
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase Src
  • RAF proto-oncogene serine/threonine-protein kinase
  • Ribosomal protein S6 kinase (P70S6K)
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Blk
  • Tyrosine-protein kinase CSK
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
  • Tyrosine-protein kinase Yes
  • Vascular endothelial growth factor receptor 2
  • 7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine
  • 7-(2,6-dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine
  • CHEMBL436137
  • US8481536, 322
3 Ki 27 IC50
  • 5-hydroxytryptamine receptor 2A
  • C-C chemokine receptor type 1
  • C-C chemokine receptor type 2
  • C-C chemokine receptor type 3
  • C-C chemokine receptor type 5
  • C-X-C chemokine receptor type 1
  • C-X-C chemokine receptor type 2
  • Cytochrome P450 2D6 (2D6)
  • D(2) dopamine receptor
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • 1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-acetylphenyl)urea
  • CHEMBL250689
30 IC50
  • NAD-Dependent Deacetylase Sirtuin-1
  • NAD-dependent deacetylase sirtuin 1
  • NAD-dependent deacetylase sirtuin 2
  • NAD-dependent protein deacetylase sirtuin-3 (SIRT3)
  • NAD-dependent protein deacetylase sirtuin-5 (SIRT5)
  • 2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide
  • CHEMBL224864
30 IC50
  • Amine oxidase [flavin-containing] B
  • Amine oxidase, copper containing
  • Lysyl oxidase
  • Lysyl oxidase homolog 2
  • Lysyl oxidase homolog 3
  • Lysyl oxidase homolog 4
  • Oxidized low-density lipoprotein receptor 1
  • Protein-lysine 6-oxidase
  • Vascular adhesion protein 1 (VAP-1)
  • CHEBI:27413
  • CHEMBL1618272
  • US10717734, Compound BAPN
17 IC50 3 Kd 10 EC50
  • 10 kDa chaperonin
  • 60 kDa chaperonin
  • Bile acid receptor
  • Bile acid receptor FXR
  • Ephrin type-A receptor 2
  • G-protein coupled bile acid receptor 1
  • HSP60/HSP10
  • Protein-tyrosine phosphatase 1B
  • Thiosulfate sulfurtransferase
  • Tyrosine-protein phosphatase non-receptor type 2
  • Ubiquitin-specific peptidase 2a (USP2a)
  • Vitamin D3 receptor
  • carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
  • (3alpha,5beta)-3-hydroxycholan-24-oic acid
  • 3alpha-hydroxy-5beta-cholan-24-oic acid
  • 3alpha-hydroxy-5beta-cholanic acid
  • 3alpha-hydroxy-5beta-cholanoic acid
  • 5beta-cholanic acid-3alpha-ol
  • CHEMBL1478
  • LCA
  • cid_9903
  • lithocholic acid
30 IC50
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
  • Sodium channel alpha subunit
  • Sodium channel alpha subunits; brain (Types I, II, III)
  • Sodium channel protein type 1 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 10 subunit alpha
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 5 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 7 subunit alpha
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Sodium channel protein type IX alpha subunit
  • Sodium channel subunit beta-2
  • Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
  • CHEMBL2325014
30 IC50
  • ALK tyrosine kinase receptor
  • Cyclin-dependent kinase 1
  • Cyclin-dependent kinase 4
  • Cyclin-dependent kinase 6
  • Ephrin type-A receptor 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Hepatocyte growth factor receptor
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Leukocyte tyrosine kinase receptor
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase 1
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase ROS
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • CHEMBL4067871
30 IC50
  • ALK tyrosine kinase receptor
  • Cyclin-dependent kinase 1
  • Cyclin-dependent kinase 4
  • Cyclin-dependent kinase 6
  • Ephrin type-A receptor 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Hepatocyte growth factor receptor
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Leukocyte tyrosine kinase receptor
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase 1
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase ROS
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • CHEMBL4105329
30 IC50
  • ALK tyrosine kinase receptor
  • Cyclin-dependent kinase 1
  • Cyclin-dependent kinase 4
  • Cyclin-dependent kinase 6
  • Ephrin type-A receptor 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Hepatocyte growth factor receptor
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Leukocyte tyrosine kinase receptor
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase 1
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase ROS
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • CHEMBL4075917
7 IC50 23 EC50
  • ABL1(Q252H)
  • ALK tyrosine kinase receptor
  • Angiopoietin-1 receptor
  • Cytoplasmic tyrosine-protein kinase BMX
  • Ephrin type-A receptor 3 (EPHA3)
  • Ephrin type-B receptor 4
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 3
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Insulin receptor
  • Lysyl-tRNA synthetase
  • Macrophage-stimulating protein receptor
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase kinase kinase kinase 2
  • NT-3 growth factor receptor
  • Non-receptor tyrosine-protein kinase TYK2
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Tyrosine kinase non-receptor protein 2
  • Tyrosine-protein kinase Fes/Fps
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase ZAP-70
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • CHEMBL459850
  • N-(3-(7-Amino-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
  • Type II inhibitor, 14
30 IC50
  • Acidic alpha-glucosidase
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Glycogen debranching enzyme
  • Lysosomal alpha-glucosidase
  • Maltase-glucoamylase
  • Multidrug resistance-associated protein 4
  • alpha-Glucosidase (α-Glucosidase)
  • CHEMBL476960
  • Voglibose
28 Ki 2 Kd
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 3A
  • 5-hydroxytryptamine receptor 5A
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Alpha-1A adrenergic receptor
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Histamine H2 Receptor
  • Histamine H3 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • Serotonin (5-HT) receptor
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • CHEMBL482496
  • N-(2-[3H-OCH3]benzyl)-2-(2-[3H-OCH3]-5-methoxy-4-iodophenyl)ethylamine
30 Ki
  • α-Carbonic anhydrase (αCA)
  • β-Carbonic anhydrase (βCA)
  • Astrosclerin-3
  • Carbonic Anhydrase XIII
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 7
  • CHEMBL450253
  • sodium fluorosulfate
30 IC50
  • Calcium channel (Type L)
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • EBifunctional epoxide hydrolase 2
  • Epoxide hydrolase 1
  • Epoxide hydrolase 2
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium channel protein type 5 subunit alpha
  • CHEMBL562822
  • N-((1R,2S)-2-phenylcyclopropyl)-4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
30 IC50
  • Beta-galactosidase
  • Beta-glucosidase
  • Ceramide glucosyltransferase
  • Glycogen debranching enzyme
  • Lactase-phlorizin hydrolase
  • Lysosomal acid glucosylceramidase
  • Lysosomal alpha-glucosidase
  • Maltase-glucoamylase
  • Sucrase-isomaltase
  • alpha-glucosidase (Gaa)
  • (2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]-2-hydroxymethyl-piperidine-3,4,5-triol
  • CHEMBL574645
  • N-adamantanemethyloxypentyl-1-deoxynojirimycin
29 IC50 1 Kd
  • DNA (cytosine-5)-methyltransferase 1
  • Histone-lysine N-methyltransferase EHMT1
  • Histone-lysine N-methyltransferase EHMT1/EHMT2
  • Protein G9a (G9a)
  • CHEMBL569864
  • N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
19 Ki 8 IC50 3 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 3A
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Histamine H1 receptor
  • Histamine H2 Receptor
  • Histamine H3 receptor
  • Histamine H4 receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M3
  • 2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole
  • 4-(2-(4-tert-butylphenylthio)ethyl)-1H-imidazole
  • CHEMBL1098230
30 IC50
  • Monoamine transporter
  • Monoamine transporters; Norepinephrine & serotonin
  • Monoamine transporters; Norepininephrine & dopamine
  • Neuroepithelial cell-transforming 1
  • Neuroepithelial cell-transforming gene 1 protein
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • CHEMBL1684056
  • N-methyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine
  • US10562878, Compound 58 E2
30 IC50
  • Angiopoietin-1 receptor
  • Aurora kinase A/Targeting protein for Xklp2
  • CDK2/CycE
  • Ephrin type-A receptor 2
  • Ephrin type-A receptor 3 (EPHA3)
  • Ephrin type-A receptor 7
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Hepatocyte growth factor receptor
  • Insulin receptor
  • Mast/stem cell growth factor receptor Kit
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Serine/threonine-protein kinase B-raf
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lyn
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 3
  • 5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenylcarbamoyl)-2-methylphenyl)ethynyl)-N,1-dimethyl-1H-imidazole-2-carboxamide
  • CHEMBL1784637
30 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • Casein kinase I isoform delta
  • Cyclin-dependent kinase 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • Insulin receptor
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 1
  • Protein kinase C (PKC)
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase PAK 4
  • Serine/threonine-protein kinase Sgk1
  • Serine/threonine-protein kinase TAO3
  • Serine/threonine-protein kinase pim-2
  • Syk protein
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 2
  • [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
  • CHEMBL1933552
6 Ki 23 IC50 1 EC50
  • ATP-binding cassette sub-family G member 2
  • Adenosine Receptors A2a (A2a)
  • Adenosine receptor A1
  • Adenosine receptor A2a and A3
  • Adenosine receptor A3
  • Alpha-chymotrypsin
  • Beta-lactamase AmpC
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
  • Equilibrative nucleoside transporter 1
  • Malate dehydrogenase cytoplasmic
  • P-glycoprotein (P-gp)
  • P-glycoprotein 1
  • P-glycoprotein 1 and 3 (MDR1a/MDR1b)
  • Transient receptor potential cation channel subfamily A member 1
  • Cardene
  • NICARDIPINE
30 IC50
  • 3-phosphoinositide dependent protein kinase-1
  • Aurora kinase B
  • Cell division cycle 7-related protein kinase
  • Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Hepatocyte growth factor receptor
  • Insulin receptor
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Platelet-derived growth factor receptor beta
  • Potassium voltage-gated channel subfamily H member 2
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase Chk1/2
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 2
  • CHEMBL2152252
30 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Serotonin (5-HT) receptor
  • Sodium-dependent serotonin transporter
  • CHEMBL183460
  • SB-649915
30 Ki
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Delta carbonic anhydrase
  • CHEMBL2324869
30 Ki
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Delta carbonic anhydrase
  • Benzene-1,3-Disulfonamide
  • CHEMBL2324868
30 IC50
  • 1,3-beta-D-glucan synthase subunit 1
  • 1,3-beta-glucan synthase component FKS1
  • 1,3-beta-glucan synthase component GSC2
  • Beta-1,3-glucan synthase
  • Fksp
  • Glucan synthase
  • CHEBI:600520
  • MICAFUNGIN
  • Micafungin
  • Mycamine
3 Ki 25 IC50 2 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Bone morphogenetic protein receptor type-2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • JAK1/TYK2
  • JAK2/JAK1
  • JAK3/JAK1
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • BMS-986165
  • Bms-986165
  • DEUCRAVACITINIB
  • Deucravacitinib
30 IC50
  • 20S proteasome
  • 26S proteosome
  • Proteasome subunit beta type-1
  • Proteasome subunit beta type-1/beta type-5
  • Proteasome subunit beta type-10
  • Proteasome subunit beta type-2
  • Proteasome subunit beta type-5
  • Proteasome subunit beta type-8
  • Proteasome subunit beta type-9
  • KZR-616
  • Kzr-616
30 IC50
  • 20S proteasome
  • 26S proteosome
  • Proteasome subunit beta type-1
  • Proteasome subunit beta type-1/beta type-5
  • Proteasome subunit beta type-10
  • Proteasome subunit beta type-2
  • Proteasome subunit beta type-5
  • Proteasome subunit beta type-8
  • Proteasome subunit beta type-9
  • CHEMBL4465456
4 Ki 24 IC50 2 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • L-type calcium channel alpha-1c/beta-2/alpha2delta-1
  • Metabotropic glutamate receptor
  • Metabotropic glutamate receptor 5
  • Sodium channel protein type 5 subunit alpha
  • CHEMBL4551786
1 Ki 29 IC50
  • 6-pyruvoyl tetrahydrobiopterin synthase
  • Dual specificity protein phosphatase 10
  • Dual specificity protein phosphatase 3
  • Dual specificity protein phosphatase 6
  • Dual specificity protein phosphatase CDC14A
  • Fas-associated protein-tyrosine phosphatase 1 (FAP1)
  • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Laforin
  • Leukocyte common antigen
  • Phosphotyrosine protein phosphatase
  • Probable low molecular weight protein-tyrosine-phosphatase
  • Protein phosphatase 2A regulatory subunit B'
  • Protein-tyrosine phosphatase
  • Protein-tyrosine phosphatase 1B
  • Protein-tyrosine phosphatase 1C
  • Protein-tyrosine phosphatase MEG2 (PTP-Meg2)
  • Receptor-type tyrosine-protein phosphatase beta (PTPβ)
  • Receptor-type tyrosine-protein phosphatase epsilon (PTPε)
  • Receptor-type tyrosine-protein phosphatase gamma
  • Receptor-type tyrosine-protein phosphatase mu (PTPμ)
  • T-cell protein-tyrosine phosphatase
  • Tyrosine-protein phosphatase non-receptor type 11
  • Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST)
  • Tyrosine-protein phosphatase non-receptor type 5
  • CHEMBL4647367
17 Ki 1 IC50
0 ΔG°
  • HIV-1 Protease
  • HIV-1 Protease A Subtype
  • HIV-1 Protease A Subtype Mutant (V82F/I84V)
  • HIV-1 Protease B Subtype
  • HIV-1 Protease B Subtype Mutant (V82F/I84V)
  • HIV-1 Protease C Subtype
  • HIV-1 Protease C Subtype Mutant (V82F/I84V)
  • HIV-1 Protease Mutant (A71V)
  • HIV-1 Protease Mutant (D30N)
  • HIV-1 Protease Mutant (D30N/A71V)
  • HIV-1 Protease Mutant (D30N/M36I)
  • HIV-1 Protease Mutant (D30N/M36I/A71V)
  • HIV-1 Protease Mutant (L10I/L90M)
  • HIV-1 Protease Mutant (M36I)
  • HIV-1 Protease Mutant (M36I/A71V)
  • HIV-1 Protease Mutant (M46I/I54V)
  • HIV-1 Protease Mutant (V82A/I84V)
  • HIV-1 Protease Mutant V6
  • HIV-1 Protease Mutant V6(46)
  • HIV-1 Protease Mutant V6(46/54/84)
  • HIV-1 Protease Mutant V6(46/84)
  • HIV-1 Protease Mutant V6(54)
  • HIV-1 Protease Mutant V6(54/84)
  • HIV-1 Protease Mutant V6(84)
  • HIV-1 Protease Mutant, MDR-HM
  • HIV-1 Protease Mutant, MDR-QM
  • Plasmepsin 2
  • (4R)-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-phenylbutanoyl]-5,5-dimethyl-N-[(2-methylphenyl)methyl]-1,3-thiazolidine-4-carboxamide
  • AG1776
  • JE-2147
  • KNI-764
30 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • BDBM256703
  • US10053456, 85
  • US10414761, Example 85
  • US9487511, 116
  • US9718814, 85
  • US9920047, 85