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Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
6 Ki 25 IC50
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4)
  • Dipeptidyl peptidase IV
  • Dipeptidyl peptidase VIII
  • (2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one
  • BMCL15687 Compound 4
  • CHEMBL98408
  • P32-98
  • thiazolidide 2
31 IC50
  • 5-hydroxytryptamine receptor 2B
  • CREB-binding protein/p53
  • DNA-dependent protein kinase
  • PI3K p110 delta/p85 alpha
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 3-kinase catalytic subunit type 3
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Phosphatidylinositol 4-kinase beta
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • US8653092, 67
2 Ki 26 IC50 2 Kd 1 EC50
  • 3C-like proteinase
  • Calmodulin/Proto-oncogene tyrosine-protein kinase Src
  • Ephrin type-A receptor 2 (EPHA2)
  • Epidermal growth factor receptor
  • Mast/stem cell growth factor receptor Kit
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine- and threonine-specific cdc2-inhibitory kinase
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase CSK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Yes
  • Vascular endothelial growth factor receptor 2
  • AZD0530
  • CHEMBL217092
  • Compound 33
  • N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine
  • Saracatinib
  • med.21724, Compound 189
31 Ki
  • Coagulation factor IX
  • Coagulation factor VII
  • Coagulation factor X
  • Coagulation factor XI
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Vitamin K-dependent protein C
  • 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride Salt
  • 1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
  • BMS-561389
  • CHEMBL206335
  • CHEMBL558198
  • DPC 906
  • Razaxaban
4 Ki 18 IC50 1 Kd 8 EC50
  • ATP-binding cassette sub-family G member 2
  • Bile salt export pump
  • Corticosteroid-binding globulin
  • Cytochrome P450 1B1
  • Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • Ghrelin O-acyltransferase
  • Solute carrier organic anion transporter family member 1A1
  • Steryl-sulfatase
  • Testis-specific androgen-binding protein
  • (1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-14-one
  • CHEMBL1405
  • Estrone
  • Estrone (E1)
  • Estrone, 15
  • Estrovarin
  • Kestrone
  • Theelin
  • Unigen
  • [2,4,6,7-3H]-E1
  • [2,4,6,7-3H]-Estrone
  • folliculin
31 IC50
  • Bile salt export pump
  • Cathepsin D
  • Pepsin A
  • Renin
  • (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide
  • ALISKIREN FUMARATE
  • Aliskiren
  • Aliskiren Hemifumarate
  • CHEMBL1639
  • Rasilez
  • TEKTURNA
12 Ki 19 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 88
  • US10150765, Example 88
  • US10703749, Example 88
  • US9464084, 88
31 Ki
  • GABA A receptor alpha-6/beta-2/gamma-2
  • GABA receptor alpha-1/beta-3/gamma-2 subunit
  • GABA receptor alpha-2/beta-2/gamma-2 subunit
  • GABA receptor alpha-2/beta-3/gamma-2 subunit
  • GABA receptor alpha-3/beta-2/gamma-2 subunit
  • GABA receptor alpha-3/beta-3/gamma-2 subunit
  • GABA receptor alpha-4/beta-3/gamma-2 subunit
  • GABA receptor alpha-5/beta-3/gamma-2 subunit
  • GABA receptor alpha-6/beta-3/gamma-2 subunit
  • GABA-A receptor; alpha-1/beta-2/gamma-2
  • GABAA Receptor, alpha-1, beta-3, gamma-2
  • GABAA Receptor, alpha-2, beta-3, gamma-2
  • GABAA Receptor, alpha-3, beta-3, gamma-2
  • GABAA Receptor, alpha-4, beta-3, gamma-2
  • GABAA Receptor, alpha-5, beta-3, gamma-2
  • GABAA Receptor, alpha-6, beta-3, gamma-2
  • CHEMBL286594
  • RY-80, 1
  • ethyl 12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate
31 IC50
  • CDK2/CycE
  • CDK2/Cyclin E/G1/S-specific cyclin E2
  • CDK7/Cyclin H/MNAT1
  • CaM Kinase II
  • CaM kinase II
  • Cyclic AMP-dependent protein kinase (PKA)
  • Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Epidermal growth factor receptor
  • Protein kinase C (PKC)
  • Protein kinase C alpha type
  • cAMP-Dependent Protein Kinase (PKA)
  • cAMP-dependent protein kinase (PKA)
  • cAMP-dependent protein kinase catalytic subunit gamma
  • 3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione
  • 6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
  • CHEMBL268368
  • arcyriaflavin A
31 IC50
  • Epidermal growth factor receptor
  • Hepatocyte growth factor receptor
  • Insulin receptor
  • Macrophage-stimulating protein receptor
  • Mast/stem cell growth factor receptor Kit
  • Platelet-derived growth factor receptor alpha
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor FLT3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 2
  • BMS-777607
  • N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
26 Ki 3 IC50 1 Kd
0 ΔG°
  • Melatonin
  • Melatonin receptor
  • Melatonin receptor type 1C
  • Quinone Reductase 2 (QR2)
  • Ribosyldihydronicotinamide dehydrogenase [quinone]
  • 2-Iodomelatonin
  • CHEMBL289233
  • Melatonin,2-Iodo
29 IC50 2 EC50
  • Bfl-1
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Glyceraldehyde-3-phosphate dehydrogenase liver
  • Heat Shock 70kDa Protein 1
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • MKP-3
  • POsterior Segregation family member (pos-1)
  • Protein fosB
  • Protein fosB/Transcription factor jun-D
  • RecName: Full=Zinc finger protein mex-5
  • Runt-Related Transcription Factor 1 Isoform AML1C
  • Voltage-gated calcium channel subunit alpha Cav2.2
  • cardiac alpha tropomyosin
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • heat shock 70kDa protein 8 isoform 2
  • large T antigen
  • neuronal munc18-1 binding protein
  • ubiquitin-conjugating enzyme E2 N
  • 6-methoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid
  • MLS000072167
  • SMR000009698
  • cid_652912
1 Ki 20 IC50 8 Kd 2 EC50
  • Acetylcholinesterase
  • Alpha-chymotrypsin
  • Beta-lactamase AmpC
  • Bile salt export pump
  • Calcium release-activated calcium channel
  • Cholinesterase
  • Cytochrome P450 121
  • Cytochrome P450 125 (CYP125)
  • Cytochrome P450 130
  • Cytochrome P450 130 (G243A)
  • Cytochrome P450 142 (CYP142)
  • Cytochrome P450 144 (CYP144)
  • Cytochrome P450 17A1
  • Cytochrome P450 3A
  • DNA recombination protein RecA
  • Heme Oxygenase 1 (HO-1)
  • Heme Oxygenase 2 (HO-2)
  • Indoleamine 2,3-dioxygenase
  • Indoleamine 2,3-dioxygenase 1
  • Indoleamine 2,3-dioxygenase 2
  • Lanosterol 14-alpha demethylase
  • Malate dehydrogenase cytoplasmic
  • Neuropeptide Y receptor type 1
  • Sterol 14α-demethylase (CYP51)
  • ubiquitin-conjugating enzyme E2 N
  • ECONAZOLE
  • Econazole nitrate
  • Gyno-pevaryl
  • Pevaryl
  • cid_68589
18 Ki 4 IC50 9 EC50
  • ADRA2A
  • Adrenergic receptor alpha-1
  • Adrenergic receptor alpha-2
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • G protein-activated inward rectifier potassium channel 1
  • MPI protein
  • adrenergic Alpha2
  • BRIMONIDINE
  • CHEMBL844
  • MLS000069370
  • SMR000058355
  • UK 14,304
  • cid_2435
31 IC50
  • Angiopoietin-1 receptor
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Dual specificty protein kinase CLK1
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Ephrin type-B receptor 4
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Fructose-1,6-bisphosphatase
  • Fructose-1,6-bisphosphatase 1 (FBPase)
  • Insulin receptor
  • Platelet-derived growth factor receptor beta
  • Receptor tyrosine-protein kinase erbB-2
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 3
  • Anilinoquinazoline deriv. 9
  • CHEMBL301018
  • N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
8 Ki 22 IC50 1 Kd
  • Bile salt export pump
  • Cytochrome P450 3A
  • N+/K+ ATPase alpha-4/beta-1
  • Na,K-ATPase alpha1beta1
  • Na,K-ATPase alpha2beta1
  • Na,K-ATPase alpha2beta2
  • Na,K-ATPase alpha2beta3
  • Na,K-ATPase isoform alpha-1 (α1)
  • Nuclear receptor ROR-gamma (RORC)
  • P-glycoprotein (P-gp)
  • P-glycoprotein 1
  • P-glycoprotein 1 and 3 (MDR1a/MDR1b)
  • Replicase polyprotein 1ab
  • STAT3
  • Sodium/potassium-transporting ATPase alpha-1 chain
  • Solute carrier organic anion transporter family member 1A4
  • Solute carrier organic anion transporter family member 1B1 (OATP1B1)
  • Solute carrier organic anion transporter family member 1B3 (OATP1B3)
  • Transcription Factor STAT1
  • DIGOXIN
  • MLS000069819
  • SMR000059217
  • US10668094, Compound Digoxin
  • cid_2724385
18 Ki 7 IC50 4 Kd 2 EC50
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M2 and M4
  • Muscarinic acetylcholine receptor M2 and M5
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • ((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-ylmethyl)-trimethyl-ammonium
  • (4-Hydroxy-5-methyl-tetrahydro-furan-2-ylmethyl)-trimethyl-ammonium; iodide
  • CHEMBL12587
  • CHEMBL292911
28 Ki 3 IC50
  • Adenosine A1 receptor
  • Adenosine A2 receptor
  • Adenosine Receptors A2a (A2a)
  • Adenosine receptor
  • Adenosine receptor A1
  • Adenosine receptor A2a
  • Adenosine receptor A2a and A3
  • Adenosine receptor A2b
  • Adenosine receptor A3
  • 8-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
  • 8-[2-(3,4-Dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
  • 8-[2-(3,4-Dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione; compound with 8-[2-(3,4-dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
  • CHEMBL1795043
  • CHEMBL27508
  • KF-17837
20 Ki 11 IC50
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • ADRA1B
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Cerebral cortex alpha adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • DRD2
  • Histamine H1 receptor
  • Serotonin 2 (5-HT2) receptor
  • 1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine
  • 1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine
  • CHEMBL303313
  • OCTOCLOTHEPIN-S
1 Ki 29 IC50 1 EC50
  • AGTR1
  • Angiotensin II AT1B
  • Angiotensin II AT2
  • Angiotensin II receptor
  • Angiotensin II receptor (AT-1) type-1
  • Angiotensin II type 1a (AT-1a) receptor
  • Peroxisome proliferator-activated receptor
  • 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine
  • 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine (L-158809)
  • 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine (L158809)
  • 2-Ethyl-5,7-dimethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine
  • 2-Ethyl-5,7-dimethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine(L-158809)
  • 4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-biphenyl-2-carboxylic acid
  • CHEMBL7550
  • L-158809
25 Ki 2 IC50 4 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • Adrenergic alpha1B
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Histamine H1 receptor
  • (5aR,9aR)-6-Propyl-5,5a,6,7,8,9,9a,10-octahydro-pyrido[2,3-g]quinazolin-2-ylamine
  • (5aR,9aR)-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinazolin-2-amine
  • 6-Propyl-5,5a,6,7,8,9,9a,10-octahydro-pyrido[2,3-g]quinazolin-2-ylamine(Quinelorane)
  • CHEMBL155731
  • Quinelorane
  • Quinerolane
6 Ki 23 IC50 2 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Multidrug resistance-associated protein 4
  • Serotonin 1d (5-HT1d) receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor
  • Uracil nucleotide/cysteinyl leukotriene receptor
  • CHEMBL905
  • MK 462 free base
  • N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine
  • N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
  • N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine
  • RIZATRIPTAN
  • risatriptan
24 Ki 7 IC50
  • Adrenergic receptor alpha-2
  • Adrenergic receptor beta
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Delta-type opioid receptor
  • Dopamine receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor
  • Opioid receptors; mu & delta
  • (3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol
  • 3-((3R,4R)-1-((S)-3-cyclohexyl-3-hydroxypropyl)-3,4-dimethylpiperidin-4-yl)phenol
  • 3-[(3R,4R)-1-((S)-3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol
  • 3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol
  • CHEMBL300662
  • LY-255582
23 Ki 3 IC50 5 EC50
  • GABA A Alpha4Beta2Gamma2
  • GABA A receptor alpha-2/beta-2/gamma-2
  • GABA A receptor alpha-3/beta-2/gamma-2
  • GABA A receptor alpha-5/beta-3/gamma-2
  • GABA A receptor alpha-6/beta-2/gamma-2
  • GABA receptor alpha-1/beta-3/gamma-2 subunit
  • GABA receptor alpha-2/beta-2/gamma-2 subunit
  • GABA receptor alpha-2/beta-3/gamma-2 subunit
  • GABA receptor alpha-3/beta-2/gamma-2 subunit
  • GABA receptor alpha-3/beta-3/gamma-2 subunit
  • GABA receptor alpha-5/beta-3/gamma-2 subunit
  • GABA receptor alpha-6/beta-3/gamma-2 subunit
  • GABA-A receptor; alpha-1/beta-2/gamma-2
  • Gamma-aminobutyric acid receptor subunit alpha-1
  • Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A))
  • 8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester
  • 8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester(RY 24)
  • CHEMBL58757
20 Ki 6 IC50 5 EC50
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Multidrug resistance-associated protein 4
  • Prostanoid EP1 Receptor
  • Prostanoid EP1 receptor
  • Prostanoid EP2 Receptor
  • Prostanoid EP2 receptor
  • Prostanoid EP3 Receptor
  • Prostanoid EP3 receptor
  • Prostanoid EP4 Receptor
  • Prostanoid EP4 receptor
  • Prostanoid IP receptor
  • Solute carrier organic anion transporter family member 2B1
  • (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid
  • (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid
  • 11alpha,15alpha-dihydroxy-9-oxo-13-trans-prostenoic acid
  • ALPROSTADIL
  • CHEMBL495
  • PGE-1
  • PGE1
  • prostaglandin E1
15 Ki 2 IC50 14 EC50
  • GRIA1
  • GRIA2
  • GRIA3
  • GRIK1
  • Glutamate receptor 1
  • Glutamate receptor ionotropic AMPA
  • Glutamate receptor ionotropic, AMPA
  • Glutamate receptor ionotropic, AMPA 2
  • Glutamate receptor ionotropic, AMPA 4
  • Glutamate receptor ionotropic, kainate
  • Glutamate receptor ionotropic, kainate 1
  • Glutamate receptor ionotropic, kainate 2
  • Ionotropic glutamate receptor kainate 2/5
  • Metabotropic glutamate receptor 1
  • NMDA receptor subunit 2C (GluN2C)
  • (R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionate
  • 2-Amino-3-(4-chloro-3-hydroxy-isoxazol-5-yl)-propionic acid
  • CHEMBL72366
21 Kd 5 Koff 5 Kon
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 13 (CA XIII)
  • Carbonic anhydrase 2
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
  • Carbonic anhydrases; II & IX
  • CHEMBL3797893
  • carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 16
21 Kd 5 Koff 5 Kon
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 13 (CA XIII)
  • Carbonic anhydrase 2
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
  • Carbonic anhydrases; II & IX
  • CHEMBL3799945
  • carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 15
12 Ki 19 IC50
  • 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3)
  • Cyclooxygenase
  • Cyclooxygenase-1 (COX-1)
  • Dipeptidyl peptidase 3
  • Prostaglandin E synthase/G/H synthase 2
  • Prostaglandin G/H synthase (Cyclooxygenase-2)
  • Prostaglandin G/H synthase (cyclooxygenase)
  • Serum paraoxonase/arylesterase 1
  • ARTHROTEC
  • DICLOFENAC SODIUM
  • GP 45840
  • SOLARAZE
  • Sodium; [2-(2,6-dichloro-phenylamino)-phenyl]-acetate
  • VOLTAREN
  • VOLTAREN-XR
  • diclofenac sodium
  • sodium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate
27 Ki 4 EC50
  • Adenosine receptor A1
  • Adenosine receptor A2a
  • Adenosine receptor A2a and A3
  • Adenosine receptor A3
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor delta
  • (2S,3S,4R,5R)-5-(2-chloro-6-(3-iodobenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrothiophene-2-carboxamide
  • (2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-N-methyl-tetrahydrothiophene-2-carboxamide
  • CHEMBL200732
18 Ki 13 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Ephrin type-B receptor 4
  • Fibroblast growth factor receptor 2
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
  • Tyrosine-protein kinase Yes
  • Vascular endothelial growth factor receptor 2
  • ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine)
  • 7-(2,6-dichlorophenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine
  • 7-(2,6-dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)-phenyl]-1,2,4-benzotriazin-3-amine
  • CHEMBL230686
  • TG-100435
  • US8481536, 367
  • US8481536, 575
31 IC50
  • Tyrosinase
  • 4-hydroxyphenyl beta-D-glucopyranoside
  • Arbutin
  • CHEMBL232202
  • hydroquinone O-beta-D-glucopyranoside
  • p-hydroxyphenyl beta-D-glucopyranoside
  • p-hydroxyphenyl beta-D-glucoside
1 Ki 30 IC50
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 17
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
  • CHEMBL409536
  • benzyl 6-benzyl-5,7-dioxo-6,7-dihydro-5H-thiazolo[3,2-c]pyrimidine-2-carboxylate
  • benzyl 6-benzyl-5,7-dioxo-6,7-dihydro-5H-thiazolo[3,2-f]pyrimidine-2-carboxylate
3 Ki 28 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Monoamine transporter
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • Transporter
  • 1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane
  • 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
  • CHEMBL528995
26 Ki 3 IC50 1 Kd 1 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Cholinesterase
  • HRH3
  • Histamine H1 receptor
  • Histamine H3 receptor
  • Histamine H4 receptor
  • 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine
  • CHEMBL462605
  • Tiprolisant
12 Ki 11 IC50 8 EC50
  • Delta-type opioid receptor
  • Mu-type opioid receptor
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • (S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hydroxyphenyl)-11-methyl-2-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecane)-N-((S)-1-((S)-1-(3,5-bis(trifluoromethyl)benzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
  • CHEMBL507340
  • H-Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-[3',5'-(CF3)2Bzl]
  • Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-3,5-Bzl(CF 3) 2
31 Ki
  • α-Carbonic anhydrase (αCA)
  • β-Carbonic anhydrase (βCA)
  • Alpha-carbonic anhydrase
  • Astrosclerin-3
  • Beta-carbonic anhydrase
  • Carbonic Anhydrase XIII
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 7
  • Gamma-carbonic anhydrase
  • CHEMBL2069541
  • CHEMBL448089
  • sodium selenocyanate
14 Ki 17 IC50
  • Cathepsin B
  • Cysteine protease
  • Cysteine protease falcipain-2
  • Cysteine protease falcipain-3
  • Hepatocyte growth factor activator
  • Hepsin
  • Matriptase
  • Plasma kallikrein
  • Plasminogen
  • Pro-cathepsin H
  • Procathepsin L
  • Thrombin
  • Transmembrane protease serine 6
  • Trypsin
  • Trypsin-1
  • (S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylamino)-4-methyl-pentanoic acid (1-formyl-4-guanidino-butyl)-amide
  • (S)-2-Acetylamino-4-methyl-pentanoic acid [(R)-1-((S)-1-formyl-4-guanidino-butylcarbamoyl)-3-methyl-butyl]-amide
  • (S)-2-Acetylamino-4-methyl-pentanoic acid [(S)-1-((S)-1-formyl-4-guanidino-butylcarbamoyl)-3-methyl-butyl]-amide
  • (S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-5-guanidino-pentanoic acid
  • (S)-2-acetylamino-4-methyl-pentanoic acid [(S)-2-(1-formyl-4-guanidino-butylamino)-4-methyl-pentanoyl]-amide
  • 2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl-4-guanidino-butylcarbamoyl)-3-methyl-butyl]-amide
  • Ac-LLR-CHO
  • Ac-Leu-Leu-Arg-H
  • CHEMBL129157
8 Ki 22 IC50 1 EC50
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • G protein-coupled receptor 44
  • Nuclear receptor subfamily 1 group I member 2
  • Potassium voltage-gated channel subfamily H member 2
  • Prostanoid DP receptor
  • Prostanoid IP receptor
  • Prostanoid TP receptor
  • (R)-2-(7-(4-fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
  • CHEMBL561132
31 IC50
  • 5-Lipoxygenase
  • Cereblon/Histone deacetylase 1
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • Leukotriene A4 hydrolase
  • 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide
  • 6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide
  • CHEMBL96051
  • GNF-Pf-2024
  • Scriptaid
  • Scriptaid, 9
22 Ki 9 IC50
  • Angiopoietin-1 receptor
  • Aurora kinase A/Targeting protein for Xklp2
  • CDK6/cyclin D1
  • Casein kinase I isoform alpha
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Dual specificty protein kinase CLK1
  • Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  • Epidermal growth factor receptor
  • Focal adhesion kinase 1
  • Homeodomain-interacting protein kinase 1
  • Insulin receptor
  • Insulin receptor-related protein
  • Insulin-like growth factor I receptor
  • Interleukin-1 receptor-associated kinase 1
  • LIM domain kinase 1
  • Misshapen-like kinase 1
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 3
  • Platelet-derived growth factor receptor beta
  • Protein kinase C iota (PKCι)
  • Protein kinase C, gamma
  • Serine/threonine-protein kinase Aurora-C
  • Serine/threonine-protein kinase Nek3
  • Serine/threonine-protein kinase PLK1
  • Serine/threonine-protein kinase VRK1
  • Serine/threonine-protein kinase WEE1
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase ABL2
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 3
  • CHEMBL1290072
  • N-(4-methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
1 Ki 29 IC50 1 Kd
  • Bile salt export pump
  • C-C chemokine receptor type 5
  • C-X-C chemokine receptor type 5
  • CCR5/mu opioid receptor complex
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Multidrug and toxin extrusion protein 1
  • Multidrug and toxin extrusion protein 2
  • Multidrug resistance-associated protein 4
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium channel protein type 5 subunit alpha
  • Solute carrier family 22 member 2
  • Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1
  • 4,4-Difluoro-cyclohexanecarboxylic acid {(S)-3-[(1S,5S)-3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-1-phenyl-propyl}-amide
  • 4,4-difluoro-N-((1S)-3-(3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
  • 4,4-difluoro-N-((S)-3-((1S,3S,5R)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza-bicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
  • 4,4-difluoro-N-((S)-3-(3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza-bicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
  • CHEMBL1201187
  • MARAVIROC
  • Selzentry
  • UK-427857
31 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 5A
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Adenosine A2 receptor
  • Adenosine receptor A1
  • Adenosine receptor A3
  • Adrenergic receptor alpha-1
  • Adrenergic receptor alpha-2
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Histamine H2 Receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • Neuronal acetylcholine receptor Alpha-4/Beta-2
  • Translocator protein
  • CHEMBL1794855
31 IC50
  • B-RAF V600E
  • EGFR (G719S)
  • EGFR (L861Q)
  • Epidermal growth factor receptor
  • Epidermal growth factor receptor (EGFR)(G719C)
  • Epidermal growth factor receptor (EGFR)(del 747-749)(A750P)
  • Epidermal growth factor receptor (EGFR)(del 747-752)(P753S)
  • Epidermal growth factor receptor (EGFR)(del 752-759)
  • Epidermal growth factor receptor (T790M)
  • Epidermal growth factor receptor(L858R)
  • Epidermal growth factor receptor(L858R, T790M)
  • Misshapen-like kinase 1 (MINK1)
  • Proto-oncogene tyrosine-protein kinase Src
  • Serine/threonine-protein kinase B-raf
  • Serine/threonine-protein kinase RIPK2
  • Tyrosine kinase non-receptor protein 2
  • Tyrosine-protein kinase BRK
  • Vascular endothelial growth factor receptor 2
  • CHEMBL2011291
  • US9416123, 6
31 IC50
  • 5'-AMP-activated protein kinase Complex 1
  • Activin receptor type-1B
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • CaM kinase I delta
  • Casein kinase I isoform delta
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Death-associated protein kinase 3
  • EPHB1
  • Epidermal growth factor receptor
  • High affinity nerve growth factor receptor
  • Insulin receptor
  • Interleukin-1 receptor-associated kinase 4
  • Ketohexokinase (KHK) Isoform C
  • Mitogen-activated protein kinase 13 (MAPK13)
  • Platelet-derived growth factor receptor beta
  • Protein kinase C theta type
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • Rho-associated protein kinase 1
  • Ribosomal protein S6 kinase alpha-3
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MST4
  • Serine/threonine-protein kinase Nek2
  • Serine/threonine-protein kinase PLK3
  • Serine/threonine-protein kinase pim-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase JAK2
  • cAMP-dependent protein kinase (PKA)
  • p21-Activated kinase 3 (PAK3)
  • CHEMBL2063926
31 IC50
  • Aurora kinase B
  • BDNF/NT-3 growth factors receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Discoidin domain-containing receptor 2
  • Eukaryotic translation initiation factor 2-alpha kinase 1
  • High affinity nerve growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • Interferon-induced, double-stranded RNA-activated protein kinase
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1
  • Mitogen-activated protein kinase kinase kinase 10
  • Mitogen-activated protein kinase kinase kinase 11
  • Mitogen-activated protein kinase kinase kinase 9 (MLK1)
  • Mitogen-activated protein kinase kinase kinase kinase 5
  • NT-3 growth factor receptor
  • Pancreatic endoplasmic reticulum kinase (PERK)
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Serine/threonine-protein kinase Nek4
  • Serine/threonine-protein kinase WNK2
  • Tyrosine-protein kinase BRK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase Yes
  • Tyrosine-protein kinase receptor UFO
  • myosin light chain kinase 2
  • CHEMBL2171124
31 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • CDK2/Cyclin A/Cyclin A1
  • CDK6/CycD3
  • CaM kinase I alpha
  • Dual specificty protein kinase CLK1
  • Ephrin type-A receptor 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • Insulin receptor
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase kinase kinase 9 (MLK1)
  • Mitogen-activated protein kinase kinase kinase kinase 4
  • P-selectin/P-selectin glycoprotein ligand 1
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MARK1
  • Serine/threonine-protein kinase MST2
  • Serine/threonine-protein kinase MST4
  • Serine/threonine-protein kinase Nek2
  • Serine/threonine-protein kinase PAK 4
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor TYRO3
  • myosin light chain kinase 2
  • CHEMBL2312649
30 IC50 1 Kd
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • BDNF/NT-3 growth factors receptor
  • Cyclin-dependent kinase 1
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit alpha
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase kinase kinase 10
  • Mitogen-activated protein kinase kinase kinase 11
  • Mitogen-activated protein kinase kinase kinase 2
  • Mitogen-activated protein kinase kinase kinase 9 (MLK1)
  • Protein delta homolog 1
  • Rho-associated protein kinase 1
  • Rho-associated protein kinase 2
  • Serine/threonine-protein kinase Aurora-C
  • Serine/threonine-protein kinase Sgk1
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase SYK
  • Tyrosine-protein kinase ZAP-70
  • Tyrosine-protein kinase receptor FLT3
  • CHEMBL2436978
  • US10485800, Example 181
26 IC50 2 Kd 3 EC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • Axin-1/Glycogen synthase kinase-3 beta
  • CaM kinase IV
  • Casein kinase I isoform delta
  • Cyclin-dependent kinase 2
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Ephrin type-B receptor 4
  • Epidermal growth factor receptor
  • Hepatocyte growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Insulin-like growth factor I receptor
  • Interleukin-1 receptor-associated kinase 4
  • Mitogen-activated protein kinase 1
  • PKC alpha and beta-2
  • RAC-alpha serine/threonine-protein kinase
  • Rho-associated protein kinase 2
  • Ribosomal protein S6 kinase
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MST2
  • Serine/threonine-protein kinase PLK3
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor FLT3
  • CHEMBL4225923
28 IC50 2 Kd 1 EC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • Axin-1/Glycogen synthase kinase-3 beta
  • CaM kinase IV
  • Casein kinase I isoform delta
  • Cyclin-dependent kinase 2
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Ephrin type-B receptor 4
  • Epidermal growth factor receptor
  • Hepatocyte growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Insulin-like growth factor I receptor
  • Mitogen-activated protein kinase 1
  • PKC alpha and beta-2
  • RAC-alpha serine/threonine-protein kinase
  • Rho-associated protein kinase 2
  • Ribosomal protein S6 kinase alpha-1/alpha-3
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MST2
  • Serine/threonine-protein kinase NEK2
  • Serine/threonine-protein kinase PLK3
  • Testis-specific serine/threonine-protein kinase 2
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor FLT3
  • CHEMBL4227082
31 IC50
  • 1,3-beta-glucan synthase component GLS2
  • 3',5'-cyclic phosphodiesterase
  • Acetylcholinesterase
  • Aurora kinase A/B
  • Aurora kinase A/Targeting protein for Xklp2
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Bromodomain-containing protein 4
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
  • Cereblon/BCR/ABL
  • Cereblon/Histone deacetylase 1
  • Cereblon/Histone deacetylase 6
  • Cholinesterase
  • Epidermal growth factor receptor
  • Estrogen receptor
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Mixed lineage kinase 7
  • Phosphodiesterase 8
  • Prostaglandin E synthase/G/H synthase 2
  • Serine/threonine-protein kinase PLK1
  • Tyrosine-protein kinase receptor FLT3
  • CHEMBL4558162
3 Ki 14 IC50 4 Kd 10 EC50
  • Casein kinase II alpha'/ beta
  • Casein kinase II subunit alpha
  • Casein kinase II subunit alpha 3
  • Casein kinase II subunit beta (CK2 beta)
  • CHEMBL4520531
29 IC50 2 EC50
  • Aurora kinase A/B
  • Aurora kinase A/Targeting protein for Xklp2
  • BRAF/CRAF
  • Calmodulin/Proto-oncogene tyrosine-protein kinase Src
  • Casein kinase II subunit alpha
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-dependent kinase 2
  • Ephrin type-B receptor 4
  • Epidermal growth factor receptor
  • Focal adhesion kinase 1/vascular endothelial growth factor receptor 3
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • Hepatocyte growth factor receptor
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Mitogen-activated protein kinase kinase kinase 8
  • NUAK family SNF1-like kinase 1
  • POsterior Segregation family member (pos-1)
  • Platelet-derived growth factor receptor beta
  • RAC-alpha serine/threonine-protein kinase
  • RecName: Full=Zinc finger protein mex-5
  • Receptor tyrosine-protein kinase erbB-2
  • Serine/threonine-protein kinase PLK1
  • Serine/threonine-protein kinase PLK4
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • 2-(4,5-dihydroxy-2-methyl-phenyl)-6-hydroxy-4-methoxy-benzoic acid
  • 2-(4,5-dihydroxy-2-methylphenyl)-6-hydroxy-4-methoxybenzoic acid
  • 4-methoxy-2-[2-methyl-4,5-bis(oxidanyl)phenyl]-6-oxidanyl-benzoic acid
  • MLS000877038
  • SMR000440664
  • cid_6918469
30 Ki 1 EC50
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • Norepinephrine transporter
  • SLC6A4
  • Serotonin (5-HT) receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • CAS_16105-77-4
  • Fenfluramine
  • Fenfluramine (+)
  • Fenfluramine (-)
  • NSC_3337
  • d-Fenfluramine
21 Ki 6 IC50 4 Kd
  • ADRA1B
  • Adrenergic alpha1B
  • Adrenergic receptor
  • Adrenergic receptor alpha
  • Alpha adrenergic receptor (1a and 1d)
  • Alpha adrenergic receptor 1A and 1B
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • HLA class I histocompatibility antigen A-3
  • Multidrug resistance-associated protein 4
  • Potassium voltage-gated channel subfamily H member 2
  • CAS_74191-85-8
  • DOXAZOSIN
  • Doxazosin
  • UK 33,274