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Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
14 IC50 18 Kd
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase SYK
  • US10533001, Example 99
  • US8501944, 372
  • US8501944, 375
  • US9868729, Example 99
2 Ki 30 IC50
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase IV
  • Dipeptidyl peptidase VIII
  • 6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile
  • BMCL15687 Compound 2
  • CHEMBL77538
  • NVP-DPP728
  • cyano-(S)-pyrrolidine deriv. 1
  • cyanopyrrolidine derivative 2
32 Ki
  • Astrosclerin-3
  • Carbonic Anhydrase III
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • 4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
  • CHEMBL51668
  • Sulfonamide 2
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 30
  • US10758542, Example 30
  • US8791123, 30
  • US9782415, Example 30
  • US9796724, Example 30
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 52
  • US10758542, Example 52
  • US8791123, 52
  • US9782415, Example 52
  • US9796724, Example 52
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 91
  • US10758542, Example 91
  • US8791123, 91
  • US9782415, Example 91
  • US9796724, Example 91
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 93
  • US10758542, Example 93
  • US8791123, 93
  • US9782415, Example 93
  • US9796724, Example 93
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 98
  • US10758542, Example 98
  • US8791123, 98
  • US9782415, Example 98
  • US9796724, Example 98
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 106
  • US10758542, Example 106
  • US8791123, 106
  • US9782415, Example 106
  • US9796724, Example 106
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 114
  • US10758542, Example 114
  • US8791123, 114
  • US9782415, Example 114
  • US9796724, Example 114
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 123
  • US10758542, Example 123
  • US8791123, 123
  • US9782415, Example 123
  • US9796724, Example 123
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 124
  • US10758542, Example 124
  • US8791123, 124
  • US9782415, Example 124
  • US9796724, Example 124
32 IC50
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10251889, Example 140
  • US10758542, Example 140
  • US8791123, 140
  • US9782415, Example 140
  • US9796724, Example 140
32 IC50
  • 3',5'-cyclic phosphodiesterase
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Phosphodiesterase (TcrPDEC)
  • Phosphodiesterase 1
  • Phosphodiesterase 2A
  • Phosphodiesterase 3
  • Phosphodiesterase 3 (PDE3)
  • Phosphodiesterase 4
  • Phosphodiesterase 8
  • Phosphodiesterase Type 10 (PDE10A)
  • Phosphodiesterase Type 11 (PDE11A)
  • Phosphodiesterase Type 2 (PDE2A)
  • Phosphodiesterase Type 3 (PDE3B)
  • Phosphodiesterase Type 4 (PDE4B)
  • Phosphodiesterase Type 4 (PDE4D)
  • Phosphodiesterase Type 5 (PDE5A)
  • Phosphodiesterase Type 7 (PDE7B)
  • Phosphodiesterase Type 9 (PDE9A)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
  • cGMP-specific 3',5'-cyclic phosphodiesterase
  • 6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-2H-pyridazin-3-one
  • 6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one
  • 6-(4-Difluoromethoxy-3-methoxy-phenyl)-2H-pyridazin-3-one
  • 6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydropyridazin-3-one
  • CHEMBL313842
  • Zaradaverine
  • Zardaverine
2 Ki 30 IC50
  • Aldehyde reductase
  • Aldo-keto reductase family 1 member C21
  • Aldo-keto reductase family member 1B10 (AKR1B10)
  • Aldose reductase
  • Aldose reductase (AR)
  • Aldose reductase-related protein 1
  • Glyoxalase I
  • (4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid
  • 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid
  • Alond
  • CHEMBL10372
  • Xedia
  • Zopolrestat
1 Ki 23 IC50 8 Kd
  • 1,3-beta-glucan synthase component GLS2
  • Cytoplasmic tyrosine-protein kinase BMX
  • Epidermal growth factor receptor
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • TEC family kinase
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase TEC
  • VHL/EGFR
  • VHL/Tyrosine-protein kinase BTK
  • BDBM166759
  • US10604504, Example 223
  • US9688629, 123
  • US9802915, Example 123
  • US9920031, Example 223
16 Ki 16 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10323032, Example 108
  • US9096596, 108
  • US9096596, 24
  • US9604982, Example 108
32 IC50
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK2
  • US10106559, Example 74
  • US10435415, Example 52
  • US9334290, 17
  • US9334290, 18
  • US9850258, Example 74
7 Ki 19 IC50 2 Kd 3 EC50 0 Other
  • 6-phosphogluconate dehydrogenase (6PGD)
  • Aldose reductase
  • Alkaline phosphatase placental-like
  • Alkaline phosphatase, tissue-nonspecific isozyme
  • Alpi
  • Anthrax toxin receptor 2
  • Apoptosis regulator Bcl-2/Bcl-2 homologous antagonist/killer
  • Arginase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 3 (CA III)
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • DNA polymerase beta
  • Fatty acid synthase
  • Glucose-6-phosphate 1-dehydrogenase
  • Human immunodeficiency virus type 1 reverse transcriptase
  • Intestinal alkaline phosphatase
  • M18 aspartyl aminopeptidase
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 14
  • Nitric Oxide Synthase, endothelial
  • Procathepsin L
  • Prostaglandin G/H synthase (cyclooxygenase)
  • Prothrombin
  • Xanthine dehydrogenase/oxidase
  • alpha-Amylase
  • alpha-Glucosidase (α-Glucosidase)
  • α-CA inhibitor, 4
  • (-)-Epicatechin
  • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
  • Epicatechin
  • L-Epicatechin
  • cid_72276
32 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450
  • Sodium channel alpha subunit
  • Sodium channel protein type 1 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 4 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 5 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Sodium channel subunit beta-2
  • US9493448, 122
  • US9493448, 154
  • US9493448, 48
  • US9597330, Example 34
  • US9845313, Example 154
16 IC50 16 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Glucocorticoid receptor
  • Liver X receptor
  • Peroxisome Proliferator-Activated Receptor alpha
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor delta
  • Retinoid X receptor
  • 2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-2-fluorophenyl)methyl](methoxycarbonyl)amino}acetic acid
  • BMS-711939
30 IC50 2 EC50
  • DNA dC->dU-editing enzyme APOBEC-3G
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Gag-Pol polyprotein
  • Glyceraldehyde-3-phosphate dehydrogenase liver
  • Heat Shock 70kDa Protein 1
  • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • MKP-3
  • POsterior Segregation family member (pos-1)
  • RecName: Full=Zinc finger protein mex-5
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • heat shock 70kDa protein 8 isoform 2
  • large T antigen
  • nuclear receptor subfamily 4, group A, member 1
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • 6,7-dimethyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid
  • MLS-0007635.0001
  • cid_646406
23 IC50 2 Kd 7 EC50
  • Apoptotic peptidase activating factor 1
  • Apurinic-apyrimidinic endonuclease 1 (APE-1)
  • Caspase-9
  • DNA recombination protein RecA
  • Heat shock protein HSP 90-beta
  • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Lipoamide Dehydrogenase (Lpd)
  • MPI protein
  • MSRA protein
  • Phospholipase A2
  • Pyruvate dehydrogenase (PDH)
  • Serine/threonine-protein kinase PLK1
  • Sphingosine 1-phosphate receptor 2
  • Trypanosoma brucei RNA editing ligase 1
  • Tyrosine-protein kinase ABL1
  • Valosin-containing protein
  • cell division cycle 42 (GTP binding protein, 25kDa)
  • cysteine protease ATG4B isoform a
  • mothers against decapentaplegic homolog 3
  • nuclear receptor corepressor 2 isoform 2
  • photoreceptor-specific nuclear receptor
  • streptokinase A precursor
  • tyrosyl-DNA phosphodiesterase 2
  • 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione
  • 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
  • 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone
  • MLS000528498
  • SMR000121073
  • US9073941, 611
  • cid_460747
26 Ki 6 IC50
  • 5-HT3A Serotonin Receptor
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Cytochrome P450 2D6
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Monoamine transporter
  • Norepinephrine transporter
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • Transporter
  • adrenergic Alpha2
  • n-AChR
  • (S,S)-reboxetine
  • Reboxetine
  • Vestra
28 Ki 4 IC50
  • DNA repair protein RAD51 homolog 1
  • Myristoyl-CoA:protein N-myristoyltransferase (Nmt)
  • neutrophil cytosolic factor 1
  • 4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothiochromen-4-ylidene)amino]benzenesulfonamide
  • 4-ethoxy-N-[(6-fluoro-1,1-dioxo-2,3-dihydro-1-benzothiopyran-4-ylidene)amino]benzenesulfonamide
  • 4-ethoxy-N-[(6-fluoro-1,1-dioxo-2,3-dihydrothiochromen-4-ylidene)amino]benzenesulfonamide
  • 4-ethoxy-N-[[6-fluoranyl-1,1-bis(oxidanylidene)-2,3-dihydrothiochromen-4-ylidene]amino]benzenesulfonamide
  • MLS000761277
  • Non peptidic, 3
  • SMR000369580
  • cid_3596078
27 Ki 4 IC50 1 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • Adrenergic alpha1B
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Histamine H1 receptor
  • 3-(4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl)-1H-indol-5-ol
  • 3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indol-5-ol
  • 3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indol-5-ol
  • CHEMBL431367
  • roxindole
19 Ki 10 IC50 1 Kd 2 EC50
  • 5-HT3A Serotonin Receptor
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Norepinephrine Monoamine transporters
  • Norepinephrine transporter
  • Serotonin 2 (5-HT2) receptor
  • Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • (+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine
  • (-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine
  • (R)-(-)-2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine
  • (S)-(+)-2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine
  • 2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine
  • 2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine((R)-(-)-MDA)
  • 3,4-methylenedioxyamphetamine
  • CHEMBL6731
  • MDA
  • MDA, (R,S)
  • MDA,R(-)
  • Tenamfetamine
  • methylenedioxyamphetamine
2 Ki 22 IC50 5 Kd 3 EC50
  • 15-Lipoxygenase (LoxA)
  • Bile salt export pump
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2J2
  • Cytochrome P450 3A
  • D(2) dopamine receptor
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Potassium channel subfamily K member 2
  • Sodium channel protein type I I alpha subunit
  • Sodium channel protein type II alpha subunit
  • Twik-RElated Potassium (K+) channel 1 (TREK1)
  • Voltage-dependent L-type calcium channel subunit beta-1/alpha-1B/alpha-2/delta-1
  • Voltage-dependent T-type calcium channel subunit alpha-1H
  • Voltage-gated T-type calcium channel
  • Voltage-gated calcium channel subunit alpha Cav2.2
  • streptokinase A precursor
  • 1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine
  • 1-[Bis-(4-fluoro-phenyl)-methyl]-4-((E)-3-phenyl-allyl)-piperazine
  • 1-[Bis-(4-fluoro-phenyl)-methyl]-4-(3-phenyl-allyl)-piperazine
  • 1-[Bis-(4-fluoro-phenyl)-methyl]-4-(3-phenyl-allyl)-piperazine(flunarizine)
  • CHEMBL30008
  • CHEMBL539027
  • Flunarizine
  • NCGC00018102
  • cid_6365505
31 Ki 1 Kd
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • Adrenergic alpha1B
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Histamine H1 receptor
  • (6,7-Dihydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dimethyl-ammonium
  • TL99
32 IC50
  • Axin-1/Glycogen synthase kinase-3 beta
  • Casein kinase I isoform delta
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 4
  • Cyclin-dependent kinase 6
  • Dual specificity mitogen-activated protein kinase kinase 1
  • Ephrin type-B receptor 4
  • Epidermal growth factor receptor
  • Hepatocyte growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Insulin-like growth factor I receptor
  • Interleukin-1 receptor-associated kinase 4
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase 11
  • Protein kinase C alpha type
  • RAC-alpha serine/threonine-protein kinase
  • Rho-associated protein kinase 2
  • Ribosomal protein S6 kinase alpha-3
  • Serine/threonine-protein kinase B-raf
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MST2
  • Serine/threonine-protein kinase Nek2
  • Serine/threonine-protein kinase PLK3
  • Testis-specific serine/threonine-protein kinase 2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 1
  • CHEMBL3356117
6 Ki 26 EC50
  • Melanocortin receptor 1
  • Melanocortin receptor 3
  • Melanocortin receptor 4
  • Melanocortin receptor 5
  • Melanocortin receptor 5 (MC5R)
  • Melanocyte-stimulating hormone receptor
  • (S)-2-{(S)-2-[(S)-2-acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide
  • 2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-DPhe-DArg-Trp-NH2
  • 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide
  • 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide(Ac-His-Phe-Arg-Trp-NH2)
  • Ac-His-D-Phe-Arg-D-Trp-NH2
  • Ac-His-DPhe-Arg-Trp-NH2
  • Ac-His-Phe-Arg-Trp-NH2
  • CHEMBL50056
24 Ki 5 IC50 3 EC50
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M2 and M5
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit
  • 6-acetoxy-8-azonia-bicyclo[3.2.1]octane
  • Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester
  • CHEMBL64000
25 Ki 7 EC50
  • Cannabinoid receptor
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • Liver fatty acid binding protein (FABP1)
  • (6aR,10aR)-3(1,1-dimethylheptyl)-9-hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • (6aR,10aR)-3-(1,1-dimethyl-heptyl)-9-hydroxymethyl-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • CHEMBL307696
  • HU-210
  • US9365534, HU-210
32 IC50
  • ALK tyrosine kinase receptor
  • BDNF/NT-3 growth factors receptor
  • Cytoplasmic tyrosine-protein kinase BMX
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Macrophage colony-stimulating factor 1 receptor (CSF1R)
  • Macrophage-stimulating protein receptor
  • Mast/stem cell growth factor receptor Kit
  • NT-3 growth factor receptor
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase ROS
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Serine/threonine-protein kinase B-raf
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Fgr
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase SYK
  • Tyrosine-protein kinase ZAP-70
  • Tyrosine-protein kinase receptor FLT3
  • Tyrosine-protein kinase receptor Tie-1
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • CHEMBL3582427
3 Ki 29 IC50
  • Excitatory amino acid transporter 1
  • Excitatory amino acid transporter 2
  • Excitatory amino acid transporter 3
  • Excitatory amino acid transporter 4
  • GRIA3
  • Glutamate receptor ionotropic, NMDA 1
  • Glutamate receptor ionotropic, kainate 1
  • (2S,3S)-2-Amino-3-benzyloxy-succinic acid
  • (2S,3S)-2-amino-3-(benzyloxy)succinic acid
  • (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID
  • CHEMBL79140
  • DL-TBOA
29 IC50 3 EC50
  • Apoptotic peptidase activating factor 1
  • Caspase-9
  • Cathepsin B
  • Cathepsin S
  • DNA damage-inducible transcript 3 protein
  • Fas-associated protein-tyrosine phosphatase 1 (FAP1)
  • Focal adhesion kinase 1
  • G-protein coupled receptor 55
  • Leukocyte common antigen
  • Lipoamide Dehydrogenase (Lpd)
  • MPI protein
  • MSRA protein
  • Neuropeptide Y receptor type 1
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • Phospholipase A2
  • Phospholipase C, gamma 1
  • Phospholipase C-beta-3
  • Procathepsin L
  • Protein-tyrosine phosphatase 1B
  • Pyruvate dehydrogenase (PDH)
  • Serine/threonine-protein kinase PLK1
  • XBP1
  • cysteine protease ATG4B isoform a
  • mothers against decapentaplegic homolog 3
  • protein artemis isoform a
  • tyrosyl-DNA phosphodiesterase 2
  • 2-Amino-phenanthrene-9,10-dione
  • CHEMBL417727
  • US9073941, 902
  • cid_254021
31 Ki 1 EC50
  • 5-HT2
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • DRD1
  • Dopamine D1 receptor
  • 2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-pyrazolo[1,5-a]pyridine
  • 2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyrazolo[1,5-a]pyridine
  • 2-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine
  • 4-(4-Chloro-phenyl)-1-pyrazolo[1,5-a]pyridin-2-ylmethyl-piperazin-1-ium
  • CHEMBL310843
32 IC50
  • 3-phosphoinositide dependent protein kinase-1
  • Axin-1/Glycogen synthase kinase-3 beta
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 4
  • Epidermal growth factor receptor
  • Hepatocyte growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit alpha
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Insulin receptor
  • MAP kinase p38
  • MAP kinase-activated protein kinase 2
  • MAP kinase-activated protein kinase 5
  • Mitogen-activated protein kinase; ERK1/ERK2
  • Protein kinase C (PKC)
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • Receptor tyrosine-protein kinase erbB-2
  • Rho-associated protein kinase 2
  • Ribosomal protein S6 kinase 2/S6K1
  • Ribosomal protein S6 kinase alpha 5
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase Sgk1
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
  • Tyrosine-protein kinase SYK
  • Tyrosine-protein kinase ZAP-70
  • Vascular endothelial growth factor receptor
  • c-Jun N-terminal kinase, JNK
  • cAMP-dependent protein kinase (PKA)
  • 2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one
  • CHEMBL281957
9 Ki 19 IC50 4 EC50
  • 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3)
  • Aldo-keto reductase family 1 member C1
  • Aldo-keto reductase family 1 member C2
  • Aldo-keto reductase family 1 member C4 (AK1C4)
  • Aldo-keto reductase family member 1B10 (AKR1B10)
  • Aldose reductase (AR)
  • Axin-1/Glycogen synthase kinase-3 beta
  • Beta-lactamase AmpC
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cyclooxygenase
  • Cyclooxygenase-1 (COX-1)
  • Cytochrome P450 2J2
  • Dihydrofolate reductase
  • Malate dehydrogenase cytoplasmic
  • Multidrug resistance-associated protein 4
  • Myeloperoxidase
  • NACHT, LRR and PYD domains-containing protein 3
  • Transient receptor potential cation channel subfamily A member 1
  • 2-(2,3-Dimethyl-phenylamino)-benzoic acid
  • 2-(2,3-Dimethyl-phenylamino)-benzoic acid(Mefenamic acid)
  • 2-(2,3-dimethylphenylamino)benzoic acid
  • CHEMBL686
  • CI-473
  • CN-35355
  • INF-3355
  • MEFENAMIC ACID
  • Ponstel
  • cid_4044
  • mefanamic acid
16 Ki 15 IC50 1 Kd
  • Bile salt export pump
  • Calcium channel (Type L)
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Multidrug resistance-associated protein 4
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium channel protein type 5 subunit alpha
  • Voltage-dependent L-type calcium channel subunit alpha-1C
  • Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1
  • Voltage-gated potassium channel subunit Kv4.3
  • (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol
  • (+)-Tolterodine
  • 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol
  • CHEMBL1382
  • TOLTERODINE
32 IC50
  • Aurora kinase B
  • Axin-1/Glycogen synthase kinase-3 beta
  • Casein kinase I isoform delta
  • Cell division cycle 7-related protein kinase
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Dual specificity mitogen-activated protein kinase kinase 1
  • Dual specificty protein kinase CLK1
  • Ephrin receptor
  • Epidermal growth factor receptor
  • Focal adhesion kinase 1
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Insulin receptor
  • Interleukin-1 receptor-associated kinase 4
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 3
  • Mitogen-activated protein kinase kinase kinase 5
  • PKC alpha and beta-2
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Protein kinase C (PKC)
  • Protein kinase C alpha type
  • Protein kinase C delta type
  • Protein kinase C theta type
  • Proto-oncogene tyrosine-protein kinase Src
  • Rho-associated protein kinase 1
  • Rho-associated protein kinase 2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase PLK1
  • Tyrosine-protein kinase JAK1
  • Vascular endothelial growth factor receptor 2
  • CHEMBL3798011
16 Ki 16 IC50
  • Acetylcholinesterase
  • Aldose reductase (AR)
  • Beta-secretase 1
  • Butyrylcholinesterase (BuChE)
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • Carbonic anhydrases; II & IX
  • Dihydroorotate dehydrogenase (fumarate)
  • Glyceraldehyde-3-phosphate dehydrogenase liver
  • Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
  • Lipoxygenase-1
  • Non-structural protein 5B (NS5B)
  • Sorbitol dehydrogenase
  • Steroid 5-alpha-reductase
  • Tyrosinase
  • Xanthine dehydrogenase/oxidase
  • Zn finger protein
  • 7-hydroxy-2H-1-benzopyran-2-one
  • 7-hydroxy-2H-chromen-2-one
  • CHEMBL51628
  • Coumarin derivative, 3a
  • beta-umbelliferone
  • hydrangin
  • skimmetin
  • umbelliferone
13 Ki 12 IC50 1 Kd 6 EC50
  • 3C-like proteinase
  • 3C-like proteinase (3CL-PRO)
  • Bile salt export pump
  • Bile salt export pump (BSEP)
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • HIV-1 protease
  • Human immunodeficiency virus type 1 protease
  • Multidrug resistance-associated protein 4
  • Protease
  • Replicase polyprotein 1ab
  • A-157378-0
  • A-157378.0
  • ABT-378
  • CHEBI:31781
  • Kaletra
  • LOPINAVIR
  • Lopinavir
  • med.21724, Compound 185
32 IC50
  • 1,3-beta-glucan synthase component GLS2
  • ALK tyrosine kinase receptor
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Hepatocyte growth factor receptor
  • Insulin-like growth factor I receptor
  • Leukocyte tyrosine kinase receptor
  • Macrophage-stimulating protein receptor
  • Mast/stem cell growth factor receptor Kit
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase ROS
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase receptor FLT3
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • CHEMBL3735648
1 Ki 31 IC50
  • Multidrug resistance protein 1/Multidrug resistance associated protein 1
  • P-glycoprotein 1
  • Reverse transcriptase
  • CHEBI:5677
  • HERNANDEZINE
  • Hernandezine
12 Ki 20 EC50
  • 5-hydroxytryptamine receptor 2A
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • CHEMBL4060461
9 Ki 22 IC50 1 EC50
  • Aldose reductase
  • Aldose reductase (AR)
  • Alkaline phosphatase placental-like
  • Alkaline phosphatase, tissue-nonspecific isozyme
  • Alpi
  • Arginase
  • Axin-1/Glycogen synthase kinase-3 beta
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 7
  • Cyclin-Dependent Kinase 5 (CDK5)
  • EBifunctional epoxide hydrolase 2
  • Intestinal alkaline phosphatase
  • Lysine-specific histone demethylase 1A
  • MPI protein
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 14
  • Neuraminidase
  • Pancreatic lipase
  • Tyrosinase
  • Tyrosine-protein kinase receptor FLT3
  • Xanthine dehydrogenase
  • Xanthine dehydrogenase/oxidase
  • 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one
  • 3,3',4',5,7-pentahydroxyflavone-3-beta-O-glucoside
  • 3-glucoside isoquercitrin
  • CHEMBL250450
  • Hyperin
  • Hyperoside
  • NSC-407304
  • Quercetin 3-O-beta-D-glucoside
  • Quercetin-3-O-beta-D-galactopyranoside
  • Quercetin-3-glucoside
  • cid_5280804
  • cid_5378597
  • hirsutrin
  • hydroside
  • isoquercetin
  • isoquercetrin
  • quercetin -3-O-beta-D-galactopyranoside
  • quercetin 3-O-beta-D-galactopyranoside
  • quercetin 3-O-beta-D-glucopyranoside
  • quercetin 3-O-galactoside
  • quercetin 3-O-glucopyranoside
  • quercetin 3-O-glucoside
  • quercetin-3-galactoside
7 IC50 25 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Core antigen
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • CHEMBL3742114
2 Ki 30 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Inward rectifier potassium channel 2
  • Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3
  • L-type calcium channel alpha-1c/beta-2/alpha2delta-1
  • Melanin-concentrating hormone receptor 2/HERG
  • Metabotropic glutamate receptor
  • Metabotropic glutamate receptor 5
  • Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
  • Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
  • Sodium channel protein type 5 subunit alpha
  • Voltage-dependent T-type calcium channel subunit alpha-1H
  • Voltage-gated potassium channel
  • CHEMBL2386850
3 Ki 28 IC50 1 Kd
  • Aurora A/TPX2 (1-43)
  • Aurora B/Incenp
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • Ephrin type-A receptor 2 (EPHA2)
  • Gamma-aminobutyric acid receptor subunit alpha-1
  • Serine/threonine-protein kinase Aurora-A
  • Tyrosine-protein kinase Lck
  • 4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-ylamino)-2-methoxybenzoic acid
  • Alisertib
  • CHEMBL483158
  • MLN8237
  • US10092556, Example MLN8237
  • US9346787, MLN8237
32 Ki
  • 5-HT3A Serotonin Receptor
  • 5-HT5B
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Alpha-1A adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • HTR1D
  • HTR6
  • Serotonin (5-HT) receptor
  • Serotonin 1B/1D receptor
  • Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • 50285557
  • 7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((2R,5S,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxo-octahydro-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-amide
  • DHE
31 IC50 1 Kd
  • Cereblon/Histone deacetylase 6
  • Epidermal growth factor receptor
  • Ferrochelatase R115L (FECH)
  • Fibroblast growth factor receptor 2
  • Histone deacetylase
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • Leukotriene A4 hydrolase
  • Proto-oncogene tyrosine-protein kinase Src
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 2
  • 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide
  • CHEMBL598797
  • CUDC-101
32 IC50
  • Aurora kinase B
  • CDK2/Cyclin A/Cyclin A1
  • Casein kinase I
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cytochrome P450 1A
  • Cytochrome P450 2A6
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase kinase kinase kinase 2
  • PKC alpha and beta-2
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Platelet-derived growth factor receptor alpha
  • Potassium voltage-gated channel subfamily H member 2
  • Protein kinase C alpha type
  • Proto-oncogene tyrosine-protein kinase Src
  • Rho-associated protein kinase 1
  • Ribosomal protein S6 kinase alpha 1
  • Serine/threonine-protein kinase Chk1/2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase HCK
  • Tyrosine-protein kinase Lyn
  • Vascular endothelial growth factor receptor 2
  • 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urea
  • CHEMBL1091356
1 Ki 30 IC50 1 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 3A
  • 5-hydroxytryptamine receptor 5A
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Adenosine receptor A1
  • Adenosine receptor A2a
  • Adenosine receptor A3
  • Beta-1 adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • HTR4
  • Histamine H1 receptor
  • Histamine H2 Receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Neurokinin 2 receptor
  • Neuromedin-K receptor
  • Neuropeptide Y receptor type 1
  • Neuropeptide Y receptor type 2
  • Serotonin 1B/1D receptor
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • 3-amino-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)butyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one
  • CHEMBL1278088
32 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • CDK2/Cyclin A/Cyclin A1
  • Casein kinase II subunit alpha
  • Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Cyclin-dependent kinase 2
  • Death-associated protein kinase 1
  • Dual specificity mitogen-activated protein kinase kinase 1
  • Dual specificity protein kinase TTK
  • Focal adhesion kinase 1
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Mitogen-activated protein kinase 14
  • PDZ-binding kinase
  • PKC alpha and beta-2
  • Platelet-derived growth factor receptor beta
  • Protein kinase C theta type
  • Proto-oncogene tyrosine-protein kinase Src
  • Serine/threonine-protein kinase B-raf
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MRCK beta
  • Serine/threonine-protein kinase Nek2
  • Serine/threonine-protein kinase PLK1
  • Serine/threonine-protein kinase PLK4
  • Serine/threonine-protein kinase WEE1
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 2
  • p21-Activated kinase 2 (PAK2)
  • 3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine
  • CHEMBL1288582
15 IC50 17 Kd
  • ATPase family AAA domain-containing protein 2
  • Bromodomain-containing protein 2
  • Bromodomain-containing protein 3
  • Bromodomain-containing protein 4
  • CREB-binding protein
  • CHEMBL1738926
32 Ki
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M3
  • CHEMBL325322
3 Ki 22 IC50 7 Kd
  • DNA polymerase
  • DNA polymerase (alpha/delta/epsilon)
  • DNA polymerase alpha subunit
  • DNA polymerase beta
  • DNA polymerase catalytic subunit
  • DNA polymerase delta subunit 1
  • Human herpesvirus 1 DNA polymerase
  • Human immunodeficiency virus type 1 reverse transcriptase
  • Reverse Transcriptase
  • Reverse transcriptase
  • Combivir
  • ZIDOVUDINE TRIPHOSPHATE
32 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • CDK2/Cyclin A/Cyclin A1
  • Casein kinase I isoform delta
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • Insulin receptor
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 1
  • P-selectin/P-selectin glycoprotein ligand 1
  • Protein kinase C (PKC)
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase PAK 4
  • Serine/threonine-protein kinase Sgk1
  • Serine/threonine-protein kinase TAO3
  • Serine/threonine-protein kinase pim-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 2
  • [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
  • CHEMBL2312304
32 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • CDK2/Cyclin A/Cyclin A1
  • Casein kinase I isoform delta
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Hepatocyte growth factor receptor
  • High affinity nerve growth factor receptor
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • Insulin receptor
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 1
  • P-selectin/P-selectin glycoprotein ligand 1
  • Protein kinase C (PKC)
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase PAK 4
  • Serine/threonine-protein kinase Sgk1
  • Serine/threonine-protein kinase TAO3
  • Serine/threonine-protein kinase pim-2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 2
  • [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
  • CHEMBL2312303
32 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • CDK2/Cyclin A/Cyclin A1
  • CDK6/CycD3
  • CaM kinase I alpha
  • Casein kinase I isoform delta
  • Dual specificty protein kinase CLK1
  • Ephrin type-A receptor 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • Insulin receptor
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase kinase kinase 9 (MLK1)
  • Mitogen-activated protein kinase kinase kinase kinase 4
  • P-selectin/P-selectin glycoprotein ligand 1
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MARK1
  • Serine/threonine-protein kinase MST2
  • Serine/threonine-protein kinase MST4
  • Serine/threonine-protein kinase Nek2
  • Serine/threonine-protein kinase PAK 4
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor TYRO3
  • myosin light chain kinase 2
  • CHEMBL2312654
32 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • CDK2/Cyclin A/Cyclin A1
  • CDK6/CycD3
  • CaM kinase I alpha
  • Casein kinase I isoform delta
  • Dual specificty protein kinase CLK1
  • Ephrin type-A receptor 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • Insulin receptor
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase kinase kinase 9 (MLK1)
  • Mitogen-activated protein kinase kinase kinase kinase 4
  • P-selectin/P-selectin glycoprotein ligand 1
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • Serine/threonine-protein kinase MARK1
  • Serine/threonine-protein kinase MST2
  • Serine/threonine-protein kinase MST4
  • Serine/threonine-protein kinase Nek2
  • Serine/threonine-protein kinase PAK 4
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor TYRO3
  • myosin light chain kinase 2
  • CHEMBL2312652
32 IC50
  • Cytochrome P450 3A
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • CHEMBL2397186
2 Ki 26 IC50 4 EC50
  • Lysine-specific demethylase 4A
  • Lysine-specific demethylase 4B
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5C
  • CHEMBL4438830
32 EC50
  • Nonstructural protein 5A
  • GS-5816
  • VELPATASVIR
  • Velpatasvir
32 IC50
  • 3',5'-cyclic phosphodiesterase
  • Aurora kinase A/B
  • Aurora kinase A/Targeting protein for Xklp2
  • Axin-1/Glycogen synthase kinase-3 beta
  • Choline kinase alpha
  • Choline/ethanolamine kinase
  • DNA-PK/Ku70/Ku85
  • Diacylglycerol kinase zeta
  • Epidermal growth factor receptor
  • Inhibitor of NF-kappa-B kinase alpha/beta
  • Leucine-rich repeat serine/threonine-protein kinase 2
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase kinase kinase 5
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4-kinase alpha (PI4KA)
  • Phosphatidylinositol 4-kinase type 2-alpha
  • Phosphatidylinositol 4-kinase, PI4K
  • Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
  • Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
  • Rho-associated protein kinase 1
  • Sphingosine kinase 1
  • Sphingosine kinase 2
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase SYK
  • mTOR/FKBP12A/FKBP12B
  • CHEMBL4561692
32 Ki
  • CHRM4
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • CAS_98299-40-2
  • HHSiD
  • NSC_3602
  • hexahydrosiladifenidol
2 Ki 30 IC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 2A
  • Cerebral cortex alpha adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • DRD1
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin 2a (5-HT2a) receptor
  • adrenergic Alpha2
  • CAS_121851
  • CHEMBL11592
  • CHEMBL301060
  • NSC_121851
  • S 20499
27 Ki 5 IC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Beta-2 adrenergic receptor
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Histamine H1 receptor
  • Multidrug resistance-associated protein 4
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • Norepinephrine transporter
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • adrenergic Alpha2
  • CAS_23047-25-8
  • Lofepramine
  • NSC_3947
  • US8629135, SW-06
31 Ki 1 Kd
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 2C (5HT2C)
  • Alpha-1A adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Gamma-aminobutyric acid receptor subunit alpha-1
  • HTR2C
  • HTR4
  • Histamine H1 receptor
  • Serotonin (5-HT) receptor
  • Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
  • adrenergic Alpha2
  • CAS_3277600
  • NSC_3277600
  • SB204741
32 Ki
  • 72 kDa type IV collagenase
  • Angiotensin-converting enzyme
  • Collagenase 3
  • Interstitial collagenase
  • Matrix Metalloproteinase-10 (MMP-10)
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • TNF-alpha-Converting Enzyme
  • MMP Inhibitor, 3
  • Thiophene derivative, compound 36
  • US8691753, 97