PMID

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Article Title

Organization

Recent Progress in Histone Demethylase Inhibitors.

University Of Oxford

Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors.

China Pharmaceutical University

Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation.

Sungkyunkwan University

Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.

Janssen Research And Development

Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors.

Glaxosmithkline

[(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues.

Sungkyunkwan University

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

University Of Oxford

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.

TBA

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

University Of Oxford

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

Merck Research Laboratories

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.

University Of Oxford

A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.

Procter And Gamble Pharmaceuticals

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.

Procter And Gamble Pharmaceuticals

Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.

Procter And Gamble Pharmaceuticals

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors.

Procter And Gamble Pharmaceuticals

Lysine demethylases inhibitors.

Kyoto Prefectural University Of Medicine

Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides.

Korea Institute Of Science And Technology

Inhibitors of histone demethylases.

University Of Copenhagen

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

Nagoya City University

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.

University Of Oxford

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

University Of Oxford

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors.

Amgen

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

Amgen

Pyrazolo[4,3-

Mitsubishi Tanabe Pharma

Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.

Universit£

Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications.

China Pharmaceutical University

Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light.

China Pharmaceutical University

Inhibition of a viral prolyl hydroxylase.

University Of Oxford

Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia.

Merck

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

Sapienza University Of Rome

Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases.

Cadila Healthcare

Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia.

Japan Tobacco

Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia.

China Pharmaceutical University

Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia.

Taisho Pharmaceutical

Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries.

Stockholm University

A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.

Schering-Plough Research Institute

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.

Glsynthesis

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: functionalization of the benzopyran A-ring.

Eli Lilly

Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.

Johnson & Johnson Pharmaceutical

Hydrophobic benzoic acids as inhibitors of influenza neuraminidase.

University Of Alabama At Birmingham

Nucleation of an allosteric response via ligand-induced loop folding.

University Of Maryland College Park