PMID

Data

Article Title

Organization

Synthesis of fluorescent probes directed to the active site gorge of acetylcholinesterase.

The University Of Montana

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.

University Of Ljubljana

Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction.

University Institute Of Pharmaceutical Sciences

Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.

Ume£

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.

University Of Ljubljana

Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.

Kyung Hee University

Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.

University Of Ljubljana

Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors.

Kyung Hee University

Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.

Ume£

Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.

Fudan University

A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.

University Of Missouri St. Louis

Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.

Csir-Central Drug Research Institute

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.

Universit£

Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.

Fudan University

Fragment-based drug discovery.

Sunesis Pharmaceuticals

Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.

Eisai

Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.

University Of South Carolina

Activation of the endocannabinoid system by organophosphorus nerve agents.

University Of California

Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors.

Kyoto University

Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors.

Kyoto University

 

Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds

TBA

Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.

Warner-Lambert

Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.

Pfizer

Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.

Eisai

A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides.

Gyeongsang National University

Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.

Wyeth Research