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111 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions.EBI
University Of Auckland
Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors.EBI
Bristol-Myers Squibb Research And Development
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.EBI
Incyte
Non-kinase targets of protein kinase inhibitors.EBI
The University Of Sydney
Fused Heterocyclic Compounds as Potent Indoleamine-2,3-dioxygenase 1 Inhibitors.EBI
Indian Institute Of Technology
Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties.EBI
Xihua University
O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.EBI
Bryn Mawr College
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.EBI
National Health Research Institutes
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.EBI
National Health Research Institutes
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.EBI
National Health Research Institutes
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.EBI
Colorado College
Indoleamine 2,3-dioxygenase inhibitors: potential treatment for cancer, sepsis, and more.EBI
Therachem Research Medilab (India)
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Swiss Institute Of Bioinformatics
Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors.EBI
National Health Research Institutes
Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.EBI
Dainippon Sumitomo Pharma
Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties.EBI
University Of Namur (Unamur)
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).EBI
University Of Auckland
Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice.EBI
Fudan University
Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.EBI
Toho University
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.EBI
University Of Namur
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.EBI
University Of Nottingham
Halicloic acids A and B isolated from the marine sponge Haliclona sp. collected in the Philippines inhibit indoleamine 2,3-dioxygenase.EBI
University Of British Columbia
Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.EBI
Ludwig Center For Cancer Research Of The University Of Lausanne
Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.EBI
Paris-Sud University
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.EBI
University Of Namur
S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase.EBI
University Of Shizuoka
Rational design of indoleamine 2,3-dioxygenase inhibitors.EBI
Institute For Cancer Research
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.EBI
Incyte
Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen.EBI
Macquarie University
Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors.EBI
Fudan University
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.EBI
University Of Namur
Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors.EBI
Vertex Pharmaceuticals
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.EBI
University Of Namur
Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies.EBI
Gyeongsang National University
Biomimetic synthesis of the IDO inhibitors exiguamine A and B.EBI
University Of California
Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors.EBI
The University Of Tokushima
Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.EBI
University Of British Columbia
Discovery of novel hydroxyamidine derivatives as indoleamine 2,3-dioxygenase 1 inhibitors with in vivo anti-tumor efficacy.EBI
Fudan University
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors.EBI
Merck
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase.EBI
Tongji University
Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Fudan University
Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).EBI
Merck
Design, synthesis and biological evaluation of 2,5-dimethylfuran-3-carboxylic acid derivatives as potential IDO1 inhibitors.EBI
China Pharmaceutical University
1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2).EBI
Sib Swiss Institute For Bioinformatics
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).EBI
Sib Swiss Institute Of Bioinformatics
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.EBI
Merck
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors.EBI
China Pharmaceutical University
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.EBI
Nanjing Medical University
Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity.EBI
Osaka University
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor ?.EBI
Chinese Academy Of Sciences
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.EBI
Fudan University
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.EBI
Universit£
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.EBI
Guangxi Normal University
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.EBI
National Health Research Institutes
Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.EBI
Fudan University
4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors.EBI
Xihua University
Discovery of Clinical Candidate (1EBI
Newlink Genetics
Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.EBI
Shanghai Hengrui Pharmaceutical
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to EBI
Universit£
DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors.EBI
Glaxosmithkline
-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase.EBI
Fudan University
Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors.EBI
Shanghai Institute Of Materia Medica (Simm)
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.EBI
Genentech
Design, synthesis and biological evaluation of novel aryl-acrylic derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Shenyang Pharmaceutical University
Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.EBI
Phenex Pharmaceuticals
Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors.EBI
Zhengzhou University
Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase.EBI
Bryn Mawr College
Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.EBI
Sib Swiss Institute Of Bioinformatics
Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors.EBI
Peking University
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors.EBI
East China University Of Science And Technology
Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors.EBI
Peking University
Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity.EBI
Okayama University
Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.EBI
China Pharmaceutical University
Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies.EBI
China Pharmaceutical University
Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches.EBI
China Pharmaceutical University
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies.EBI
Universit£
Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Bristol-Myers Squibb Research And Development
Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold.EBI
University Health Network
Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy.EBI
China Pharmaceutical University
Fragment-based approach to identify IDO1 inhibitor building blocks.EBI
University Of Perugia
Polyketides and Anthranilic Acid Possessing 6-Deoxy-?-l-talopyranose from a Streptomyces Species.EBI
Korea Research Institute Of Bioscience And Biotechnology
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.EBI
Iteos Therapeutics
Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase.EBI
University Of Namur
Recent synthetic and medicinal perspectives of tryptanthrin.EBI
Indo-Soviet Friendship College Of Pharmacy (Isfcp)
Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Fudan University
Novel amidino-substituted benzimidazoles: synthesis of compounds and inhibition of dipeptidyl peptidase III.BDB
The Josip Juraj Strossmayer University
In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency.BDB
Merck Research Laboratories
Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.BDB
R. W. Johnson Pharmaceutical Research Institute
Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus.BDB
The University Of Chicago
Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.BDB
Riken Advanced Science Institute
Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes.BDB
TBA
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.BDB
The Johns Hopkins University
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.BDB
Abbott Laboratories
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).BDB
Bristol-Myers Squibb
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.BDB
University Of Bath
Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1.BDB
University Of Oxford
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates.BDB
Istituto Di Cristallografia
Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR.BDB
Bristol-Myers Squibb