96 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Soluble epoxide hydrolase inhibitors of indolinone alkaloids and phenolic derivatives from Cimicifuga dahurica (Turcz.) Maxim.
Chungnam National University
Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa.
University Of California
Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase.
Chungnam National University
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators.
Goethe-University Frankfurt
1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors.
University Of California Davis
Constituents of the seeds of Cassia tora with inhibitory activity on soluble expoxide hydrolease.
Chungnam National University
Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase.
Ehime University
Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe.
Chungnam National University
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
University Of California Davis
Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening.
Astellas Pharma
Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors.
Sumitomo Dainippon Pharma
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.
University Of Texas Southwestern Medical Center
Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors.
Volzhsky Polytechnic Institute (Branch) Volgograd State Technical University
Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography.
Astellas Pharma
Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice.
Astrazeneca
Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action.
Dainippon Sumitomo Pharma
Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.
Toray Industries
Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase.
Ehime University
Exploring the chemical space of multitarget ligands using aligned self-organizing maps.
Goethe University
Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.
Toray Industries
Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.
University Of California
Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.
University Of California
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
Glaxosmithkline
Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.
St. Jude Children'S Research Hospital
Synthesis and biological activity of 4-substituted benzoxazolone derivatives as a new class of sEH inhibitors with high anti-inflammatory activity in vivo.
Shanxi Medical University
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.
Goethe-University Frankfurt
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Columbia University
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.
Zafes/Liff/Osf Goethe-University Frankfurt
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening.
Johann Wolfgang Goethe University
Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase.
University Of California
Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering.
TBA
Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability.
Colorado State University
A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors.
Dainippon Sumitomo Pharma
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Merck Research Laboratories
Orally bioavailable potent soluble epoxide hydrolase inhibitors.
University Of California Davis
Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.
Columbia University
The structure-activity relationship of urea derivatives as anti-tuberculosis agents.
St. Jude Children'S Research Hospital
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
University Of California
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.
Ar£Te Therapeutics
Incorporation of Piperazino Functionality into 1,3-Disubstituted Urea as the Tertiary Pharmacophore Affording Potent Inhibitors of Soluble Epoxide Hydrolase with Improved Pharmacokinetic Properties
TBA
Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.
Boehringer Ingelheim Pharmaceuticals
1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.
Department Of Entomology And University Of California Davis Cancer Center
Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method.
Boehringer Ingelheim Pharmaceuticals
Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N'-diaryl urea inhibitors of soluble epoxide hydrolase.
Ar£Te Therapeutics
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.
Merck Research Laboratories
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.
Boehringer Ingelheim Pharmaceuticals
Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase.
Boehringer Ingelheim Pharmaceuticals
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.
Merck Research Laboratories
Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.
Boehringer Ingelheim Pharmaceuticals
Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase.
Arete Therapeutics
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.
University Of Texas Southwestern Medical Center
Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.
Merck Research Laboratories
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Columbia University
Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.
Department Of Entomology And University Of California Davis Cancer Center
Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors.
ArêTe Therapeutics
1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties.
Department Of Entomology And University Of California Davis Cancer Center
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase.
Department Of Entomology And University Of California Davis Cancer Center
Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors.
University Of California
Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase.
University Of California
Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility.
Department Of Entomology And University Of California Davis Cancer Center
Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.
University Of California Davis
QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds.
The Pennsylvania State University
Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase.
Goethe-University
DNA-Encoded Library Screening as Core Platform Technology in Drug Discovery: Its Synthetic Method Development and Applications in DEL Synthesis.
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)
Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility.
University Of California Davis
Challenges of docking in large, flexible and promiscuous binding sites.
The Barcelona Institute For Research In Biomedicine (Irb Barcelona)
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Goethe-University Frankfurt
Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.
Universitat De Barcelona
Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors.
University Of Innsbruck
Multitarget PPAR? agonists as innovative modulators of the metabolic syndrome.
University Of Chieti "G. D.Annunzio
Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.
Northwest University
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA
Goethe University Frankfurt
Computer-Aided Selective Optimization of Side Activities of Talinolol.
Goethe-University Of Frankfurt
Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase.
Chinese Academy Of Sciences
NMR-Based Investigation of Hydrogen Bonding in a Dihydroanthracen-1(4 H)one from Rubia philippinensis and Its Soluble Epoxide Hydrolase Inhibitory Potential.
Yale University
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Goethe University Frankfurt
Inhibition Potential of Cycloartane-Type Glycosides from the Roots of Cimicifuga dahurica against Soluble Epoxide Hydrolase.
Chungnam National University
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
University Of California Davis
Adamantyl thioureas as soluble epoxide hydrolase inhibitors.
University Of California Davis
Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.
University Of California Davis
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.
Goethe-University Frankfurt
